DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and opa1

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_009300789.1	Gene:	opa1 / 492332	ZFINID:	ZDB-GENE-041114-7	Length:	1034	Species:	Danio rerio

Alignment Length:	1010	Identity:	512/1010 - (50%)
Similarity:	678/1010 - (67%)	Gaps:	108/1010 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 HEEFLLAGNP--------ARGW-------QMPPPSR--GYG------MLVVRILRGALKLRYIVL 97
            |..:....||        ||.:       ..||.||  |:|      ..|.|:....||||||:|
Zfish    40 HHRYSANNNPQRPPHCSAARHYTSLSRLPMRPPKSRSGGHGYQQHRTFWVARLAARLLKLRYILL 104

  Fly    98 GGAIGGGVSLSKKYEEWKDGL----------PNFKW----------LEDAMPQ------------ 130
            |.|:|||.:..|.|:|||:.|          |:|.|          |..|:|:
Zfish   105 GSAVGGGYTAKKTYDEWKEMLPDMSEYTWIVPDFVWELSENIDLDKLASALPELEEIAKLLPDME 169

  Fly   131 --GERWSQFSRNLIE--VGSLVKNAIEVDPKLKQLGEDKLSEWRNWFDSRLDDAIEA----AD-- 185
              ||.:: |.::|:.  :||.|..|..:...|:..||..|         |..|...|    ||
Zfish   170 KIGENFT-FLKSLLSSGLGSEVNGASGLRLLLETTGESAL---------RAPDVPPASAAMADSG 224

  Fly   186 -----YQGV---------QIVETKDDLK-------------AKTTVAALGITSDESRKKYEKLQS 223
                 .||:         ||.:.:::::             ...:.|.....|...||..:|  .
Zfish   225 DKQFKKQGLLSELIVIQQQIQQHEEEMRRAAANNAPPPPRDPSPSPAPNPSPSQSKRKSSDK--E 287

  Fly   224 QVETLQTEIMNVQIKYQKELEKMEKENRELRQQYLILKTNKKTTAKKIKKSLIDMYSEVLDELSG 288
            :|:.||.|::..|:|||:.||::||||:||| :.::.|.:|....:|:|||||||||||||.||.
Zfish   288 KVDQLQEELLRTQLKYQRMLERLEKENKELR-KVVLQKDDKGIHQRKVKKSLIDMYSEVLDILSD 351

  Fly   289 YDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTLAEGPYHVAQFR 353
            ||:.|...|||||||||||||:|||||||.||:||||||||||||||:||||||:|||:|||.|:
Zfish   352 YDSNYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTLSEGPHHVAMFK 416

  Fly   354 DSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMT 418
            ||.||:||.||.||..||.::|.||:.||:.|:|||.|.|:::|||||:||||||||||:|||:|
Zfish   417 DSSREFDLGKEEDLAALRHEIELRMRKSVKEGQTVSPETISLSVKGPGIQRMVLVDLPGVISTVT 481

  Fly   419 VDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLA 483
            ..||:|||::|..::|.||.|||||||||||||||||||.|||||.|.||.|:||||||||||||
Zfish   482 TGMAADTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPQGKRTIFVLTKVDLA 546

  Fly   484 EE-LADPDRIRKILSGKLFPMKALGYYAVVTGRGRKDDSIDAIRQYEEDFFKNSKLFHRRGVIMP 547
            |: ||.|.||::|:.|||||||||||:|||||:|..::|||:|:.||||||:||:|. :.|::..
Zfish   547 EKNLASPSRIQQIVEGKLFPMKALGYFAVVTGKGSPNESIDSIKDYEEDFFQNSRLL-KDGMLKA 610

  Fly   548 HQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDELFDKAKGEI 612
            ||||::||||||||.|||||||::|||||||||:|||||||||||:|||||..|:||::|||.||
Zfish   611 HQVTTKNLSLAVSDCFWKMVRESVEQQADAFKASRFNLETEWKNNYPRLRELDRNELYEKAKNEI 675

  Fly   613 LDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSFNTMVDIKLRQWAEQALP 677
            ||||::|||::.|.|:..|..||||::|.:|.|:|||||||:.:..:|||.|||||:||.::.||
Zfish   676 LDEVISLSQVTPKHWESILQKKLWERVSTHVIENIYLPAAQTMNSGTFNTTVDIKLKQWTDKQLP 740

  Fly   678 AKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDMLRVIQLNTL 742
            .|::|..||.||:||...| ...|.:|.|.|||:||.||.||:|:||.|.::|:|.|||||.|.|
Zfish   741 HKALEVAWETLQEEFARFM-AEYKGKDQDDIFDKLKEAVKDESIKRHKWNERAMDSLRVIQHNAL 804

  Fly   743 EDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLTQDQQKRRSVKNEL 807
            |||.:.||.:||:|::|:|.::.::|..||..:|.|.||...:|...|:..|.:|..|...||||
Zfish   805 EDRSITDKPQWDAAIQFMEETLQSRLKDTESVIADMVGPDWKQRWMSWKNRTPEQHTRNETKNEL 869

  Fly   808 DKILKNDTKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFPVYRKHFLQQALQRAKDCRKAY 872
            :::||....|...|.:||:|||||||:...|:||...|:.||..::|:||||:||.....||:.:
Zfish   870 ERLLKLHEDHTAYLANDEVTTVRKNLEARGVEVDPVLIKDTWHQLFRRHFLQKALLHCNLCRRGF 934

  Fly   873 YLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVINREARRLDKEIKAVLDEFSDDEEKKG 937
            |.|.:...:.|:.|:|||||||||:::.||.|.||||:.|.|.|||:|.:|.||::|.:|.|||.
Zfish   935 YYYQRHFVDSELECNDVVLFWRIQRMLGITANTLRQQLTNTEVRRLEKNVKEVLEDFGEDNEKKV 999

  Fly   938 YLLTGKRVLLAEELIKVRQIQEKLEEFINSLNQEK 972
            .|:||:||.|||:|.|||:||||||.||.:|::||
Zfish  1000 QLITGRRVQLAEDLKKVREIQEKLEAFIEALHKEK 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	196/274 (72%)
opa1	XP_009300789.1	DLP_1	361..635	CDD:206738	196/274 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574113
Domainoid	1	1.000	564	1.000	Domainoid score	I230
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14618
Inparanoid	1	1.050	946	1.000	Inparanoid score	I329
OMA	1	1.010	-	-		QHG52400
OrthoDB	1	1.010	-	-		D202097at33208
OrthoFinder	1	1.000	-	-		FOG0006841
OrthoInspector	1	1.000	-	-		oto41028
orthoMCL	1	0.900	-	-		OOG6_105511
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3740
SonicParanoid	1	1.000	-	-		X4932
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800