DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Opa1 and MX2

DIOPT Version :9

Sequence 1:NP_725369.1 Gene:Opa1 / 36578 FlyBaseID:FBgn0261276 Length:972 Species:Drosophila melanogaster
Sequence 2:NP_002454.1 Gene:MX2 / 4600 HGNCID:7533 Length:715 Species:Homo sapiens


Alignment Length:773 Identity:167/773 - (21%)
Similarity:305/773 - (39%) Gaps:166/773 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 SDESRKKYEKLQSQVETLQTE-----IMNVQIKYQKELEKMEKENRELRQQYLILKTN------- 263
            |..|.:||  |:.::.:.|.:     .:..|:.:....:..||:...|.:.:..|..|       
Human    14 SQFSSRKY--LKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLAKDFNFLTLNNQPPPGN 76

  Fly   264 -KKTTAKKIKKSLIDMYS-------EVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIA 320
             .:..|...:.:|...|.       :::|.|........:|  ||.:.|:|||||||:||||:::
Human    77 RSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLA--LPAIAVIGDQSSGKSSVLEALS 139

  Fly   321 KARIFPRGSGEMMTRAPVKVTLAEGPYHVAQFRDSDREYDLTKESDLQD---LRRDVEFRMKASV 382
            ...: ||||| ::||.|:.:.|.:.|......|.|.|..:|    :|||   :.:::........
Human   140 GVAL-PRGSG-IVTRCPLVLKLKKQPCEAWAGRISYRNTEL----ELQDPGQVEKEIHKAQNVMA 198

  Fly   383 RGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCI 447
            ..|:.:|:|:|::.:..|.:..:.::|||||......:...|....|..:.|.|:.....|.|.:
Human   199 GNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVV 263

  Fly   448 QDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVV 512
            ...:||...:....:..:.||.|.|||.:|||.||.:...:.. :..::....:|:|.  .|.:|
Human   264 VPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMDRGTEKS-VMNVVRNLTYPLKK--GYMIV 325

  Fly   513 TGRGRKDD----SIDAIRQYEEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETI-- 571
            ..||:::.    |:....:.|..||:....|  |.::.....|...|:..::......:::::  
Human   326 KCRGQQEITNRLSLAEATKKEITFFQTHPYF--RVLLEEGSATVPRLAERLTTELIMHIQKSLPL 388

  Fly   572 ------------------------EQQADAF-----KATRFNLETEWKNNFPRLRESGRDELFDK 607
                                    .|:||..     |...||.:.|.......:.......|::|
Human   389 LEGQIRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVRENETRLYNK 453

  Fly   608 AKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESI------YLPAAQSGSQN--SFNTMV 664
            .:.:.            |.|...|:|.. :|:.|.:.|.:      |......|..|  :|..:|
Human   454 IREDF------------KNWVGILATNT-QKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIV 505

  Fly   665 DIKLRQWAEQALPAKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAV---VDEAIRRHSW 726
            ...::|..|.||  ..::...|.:||.||::      |:.|.|.|..|...|   :::...:|: 
Human   506 HQYIQQLVEPAL--SMLQKAMEIIQQAFINV------AKKHFGEFFNLNQTVQSTIEDIKVKHT- 561

  Fly   727 EDKAIDML----RVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQ-MRR 786
             .||.:|:    |:.|:...:|:..               ||..|.|: ||....:..|.| |:.
Human   562 -AKAENMIQLQFRMEQMVFCQDQIY---------------SVVLKKVR-EEIFNPLGTPSQNMKL 609

  Fly   787 ITHWQYLTQDQQKRRSVKN-------------ELDKILKNDTKHLPTLTHDELTTVRKN---LQR 835
            .:|:      .....||.:             |..|.|.|   .:|.:.  :...:|:|   ||:
Human   610 NSHF------PSNESSVSSFTEIGIHLNAYFLETSKRLAN---QIPFII--QYFMLRENGDSLQK 663

  Fly   836 DNVDVDTDYIRQTWFPVYRKHFLQQALQRAKDCR----KAYYLYTQQGAECEISCSDV 889
            ..:.:..:..|.:|       .||:..:.|...|    :.|.|...:.|.|:.|..::
Human   664 AMMQILQEKNRYSW-------LLQEQSETATKRRILKERIYRLTQARHALCQFSSKEI 714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Opa1NP_725369.1 DLP_1 298..572 CDD:206738 74/306 (24%)
MX2NP_002454.1 nuclear localization signal (NLS) 1..24 5/11 (45%)
DLP_1 116..387 CDD:206738 75/283 (27%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 125..132 6/6 (100%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 150..152 0/1 (0%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 225..228 2/2 (100%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 294..297 2/2 (100%)
Dynamin_M 307..593 CDD:307257 60/327 (18%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 326..329 0/2 (0%)
GED 621..709 CDD:128597 19/99 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0699
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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