Protein Alignment Opa1 and MX1

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_002453.2
• Gene: MX1 / 4599
• HGNCID: 7532
• Length: 662
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 151/687 - (21%)
• Similarity: 280/687 - (40%)
• Gaps: 126/687 - (18%)

  Fly   259 ILKTNKKTTAKK-----IKKSLIDMYSE-------VLDELSGYDTGYTMADHLPRVVVVGDQSSG 311
            :|.....|.|:|     .:.:|...|.|       ::|.|........:|  ||.:.|:||||||
Human    20 LLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLA--LPAIAVIGDQSSG 82

  Fly   312 KTSVLESIAKARIFPRGSGEMMTRAP----VKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRR 372
            |:||||:::...: ||||| ::||.|    :|..:.|..:   :.:.|.::|:: :.||..::.:
Human    83 KSSVLEALSGVAL-PRGSG-IVTRCPLVLKLKKLVNEDKW---RGKVSYQDYEI-EISDASEVEK 141

  Fly   373 DVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYM 437
            ::.....|....|..:|:|:|.:.:....:..:.|:|||||......:..:|....|..:.|.|:
Human   142 EINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYI 206

  Fly   438 SNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFP 502
            .....|.|.:...:||...:....:..:.||.|.|||.:|||.||.:: ...|::..::...:|.
Human   207 QRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDK-GTEDKVVDVVRNLVFH 270

  Fly   503 MKALGYYAVVTGRGRKDD----SIDAIRQYEEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRF 563
            :|.  .|.:|..||:::.    |:....|.|:.||:|...|  |.::...:.|...|:..::...
Human   271 LKK--GYMIVKCRGQQEIQDQLSLSEALQREKIFFENHPYF--RDLLEEGKATVPCLAEKLTSEL 331

  Fly   564 WKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDELFDKAKGEILDEVVTLSQ-ISA--- 624
            ...:.:::....:..|.|...:..|.:.....:.|...:::|     .::|:|...:| |:|
Human   332 ITHICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMF-----FLIDKVNAFNQDITALMQ 391

  Fly   625 --------------------KKWDDALSTKLWEK---LSNYV--FESIYLPAAQSGSQN--SFNT 662
                                .||...:.....|.   ||..:  ||:.|......|..|  :|.|
Human   392 GEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFET 456

  Fly   663 MVDIKLRQWAEQALPAKSVEAGWEALQ---------QEFISLMERSKKAQDHDGIFDQLKSAVVD 718
            :|..:::...|.|:...........|.         :||.:| .|:.|::..|...:|.:..  :
Human   457 IVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNL-HRTAKSKIEDIRAEQEREG--E 518

  Fly   719 EAIRRHSWEDKAI--------DMLRVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETL 775
            :.||.|...::.:        ..|:.::...||:.  ..|:.||... |..||.      |:.::
Human   519 KLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEE--KKKKSWDFGA-FQSSSA------TDSSM 574

  Fly   776 AQMFGPGQMRRITHWQYLTQDQQKRRSVKNELDKILKNDTKHLPTLTH-DELTTVRKNLQRDNVD 839
            .::|        .|.....|:..||.|             .|:|.:.. ..|.|..:.||:..:.
Human   575 EEIF--------QHLMAYHQEASKRIS-------------SHIPLIIQFFMLQTYGQQLQKAMLQ 618

  Fly   840 VDTDYIRQTWFPVYR------KHFLQQALQRAKDCRK 870
            :..|....:|....|      :.||::.|.|....|:
Human   619 LLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARR 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	75/281 (27%)
		OPA1_C	629..972	CDD:466080	54/273 (20%)
MX1	NP_002453.2	DLP_1	68..340	CDD:206738	76/284 (27%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	77..84		6/6 (100%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	102..104		0/1 (0%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	178..181		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	247..250		2/2 (100%)
		Dynamin_M	259..546	CDD:460033	53/298 (18%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	279..282		0/2 (0%)
		Bundle signaling element (BSE)	341..366		3/24 (13%)
		Middle domain	366..533		33/174 (19%)
		Stalk	367..632		56/302 (19%)
		Critical for lipid-binding	554..557		0/2 (0%)
		GED	571..660	CDD:128597	20/106 (19%)