DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and fzo

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	96/518 - (18%)
Similarity:	174/518 - (33%)	Gaps:	135/518 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 KKSLIDMYSEVLDELSGYDT---------GYTMADHL------------------PRVVVVGDQS 309
            |..|.|:|.::.:.||.:.|         ...|.:||                  .:|...|..|
  Fly    32 KTELQDIYHDLSNYLSNFLTILEETVLLKDRQMLEHLCAFSSRVEAIAKVLSRDRMKVAFFGRTS 96

  Fly   310 SGKTSVLESIAKARIFPRGSGEMMT-RAPVKVTLAEGPYHVAQFRDSDREYDLTKESDLQD---- 369
            :||::|:.::...:|.|...|...: ...|:...:....|| :....|...:|:..|.|..
  Fly    97 NGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHV-KVEQEDEHMELSALSQLASAHSP 160

  Fly   370 --LRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQM 432
              |:.....::..:......:..:|             ||:|.||:..|..:|   |..||
  Fly   161 GALKPSTLLQVNMAKNRCSILDYDV-------------VLMDTPGVDVTAQLD---DCLDS---- 205

  Fly   433 TKHYMSNPNAIILCIQDGSV--DAERSNVTDLVMQCDPLGRRTIFVL-TKVDLAEELADPDRIRK 494
               |..:.:..||.:...|.  ..||....|:..:   |.|..:|:| .:.|.|..| :|:..:|
  Fly   206 ---YCMDADVFILVLNAESTVSRVERQFFKDVASK---LSRPNLFILNNRWDKASSL-EPEMEQK 263

  Fly   495 ILSGKL-----FPMKALGYYA------------------------VVTGRGRKDDSIDAIRQYEE 530
            :....:     ..:..||.|:                        :....|:.........::|.
  Fly   264 VKDQHMERCVNLLVDELGVYSTAQEAWERIYHVSALEALHIRNGQITNPSGQTQQRYQEFLRFEN 328

  Fly   531 DFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETE---W--- 589
            ||.....:...:....||.::::.:...:.........|.:.:..|..|..|.||..|   |
  Fly   329 DFSNCLAVSALKTKFGPHLLSAQKILNQLKSTLICPFIEKVSRLIDENKERRANLNAEIEDWLIL 393

  Fly   590 --------KNNFPRLRES----GRDELFDKAKGEILDEVVTLSQ-------ISAKKWDDALSTKL 635
                    :..|..|.|.    ||..|.|:.|..|...|::.||       ....::..:|...|
  Fly   394 MQEDREALQYCFEELTEMTQRVGRCVLNDQIKTLIPSSVLSFSQPFHPEFPAQIGQYQRSLCAHL 458

  Fly   636 WEKLSNYVFESIYLPAAQSGSQNSFNTMVDIKLRQWAEQALPAKSVEAGWEALQ----QEFIS 694
            .:.|.:.|.:.:.:|..:.        ::||:    .|..||.......|:.:.    |.::|
  Fly   459 DKLLEDRVLQCLSIPLQRK--------ILDIE----KEIGLPIAENSCDWQLIYGLDCQSYMS 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	56/330 (17%)
fzo	NP_732840.1	DLP_2	87..334	CDD:206739	51/274 (19%)
fzo	NP_732840.1	Fzo_mitofusin	572..716	CDD:282633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900