DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and mxg

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_009296165.1	Gene:	mxg / 360148	ZFINID:	ZDB-GENE-030721-10	Length:	645	Species:	Danio rerio

Alignment Length:	731	Identity:	156/731 - (21%)
Similarity:	308/731 - (42%)	Gaps:	171/731 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 ENRELRQQYLILKTNKKTTAKKIKKSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKT 313
            |::::|:.:..|:.:            |..|.:::|.|........:|  ||.:||:|||||||:
Zfish    31 ESQQMREVHSHLEES------------IRPYIDLIDTLRSVGIHKDLA--LPTIVVIGDQSSGKS 81

  Fly   314 SVLESIAKARIFPRGSGEMMTRAPV-----KVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRD 373
            ||||:::...: |||:| ::||.|:     |||.......|..:|:...|:     :|...:.|.
Zfish    82 SVLETLSGVAL-PRGNG-IVTRCPLELRLKKVTGGVSWKAVISYREKRTEF-----ADPSMVERH 139

  Fly   374 VEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMS 438
            |:.........|..:.:|:|.:.|..|.:..:.|:|||||..........|..:.|.::...::.
Zfish   140 VKTAQDELAGNGVGICDELITLEVMSPDVCNLTLIDLPGIARVPVAGQPDDIANQIKKLIIKFIV 204

  Fly   439 NPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPM 503
            ....|.|.:...::|...:....|..:.||.|:|||.||||.|:.::..:.: |..|:..|:.|:
Zfish   205 MQETINLVVVPCNIDIATTEALKLAQEVDPEGKRTIAVLTKPDIIDKGTEKN-ILAIVQNKVIPL 268

  Fly   504 KALGYYAVVTGRGRK----DDSIDAIRQYEEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFW 564
            :.  .|.:|..||::    |.|:|...:.|::||:|.:.|.|  ::...:.|:::|:..::....
Zfish   269 RK--GYVMVKCRGQQQIDDDISLDEATEMEKEFFQNHEFFRR--LLSEDKATTKSLANKLTQNLV 329

  Fly   565 KMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDE-----------LFDKAKGEILDEVVT 618
            ..:::::.|.::..|...::|..:.|.     .|||..:           :..|..|:|  ::::
Zfish   330 DHIKKSLPQLSEQIKKQLWDLRDDLKE-----CESGPPQDSKGAKQFLIKILTKFNGQI--KLLS 387

  Fly   619 LSQISAKK------------WDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSFNTMVDIKLRQW 671
            ..:..|:|            |:|                  :|...:...:.|....::: |:.:
Zfish   388 SGEKMAEKNLFVLLREEFNMWND------------------HLNETKKSLKQSTKEKIEV-LQNF 433

  Fly   672 AEQALPAKSVEAGWEALQQEFISLMER--SKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDML 734
            ..:.||..|....:|.:.|..::.::.  ||......||.....:.||:...:.:.
Zfish   434 RGRELPGFSNYRVFEVILQNHVATLKNPASKLLNAIKGIILGHFTEVVETCFQNYP--------- 489

  Fly   735 RVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLTQDQQK 799
             |:|..|        |.:.|:    ::||..||   .|:.:::.|   :|.|:    ..|||...
Zfish   490 -VLQSIT--------KDKIDN----IQSSQQAK---AEQRISEQF---KMERM----IFTQDPIF 531

  Fly   800 RRSVKNELDKILKNDTKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFPVYRKHFLQQALQR 864
            .:::         |:.....|.:.|||                        ||:.|.      .:
Zfish   532 LKAL---------NEIPDSETFSIDEL------------------------PVFDKK------SK 557

  Fly   865 AKDCRKAYY-LYTQQGAECEISCSDVVLFWRIQQVIK-ITGNALR-------QQVI--NREARRL 918
            ..|..:||| :..|:.|:   ....::||:.::|..| :|.:.|.       .:::  :.:..|.
Zfish   558 YSDMLEAYYEIVVQRMAD---QLPMMILFFMLKQTAKLLTADMLSLLKGVKVSELLFEDTDVSRR 619

  Fly   919 DKEIKAVLDEFSDDEE 934
            .::::|.||..|..:|
Zfish   620 RRDLQARLDRLSIAQE 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	78/282 (28%)
mxg	XP_009296165.1	DLP_1	65..337	CDD:206738	79/285 (28%)
		Dynamin_M	258..538	CDD:279383	63/350 (18%)
		GED	561..640	CDD:280391	17/78 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810