DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Opa1 and mxc

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_001007285.1	Gene:	mxc / 360145	ZFINID:	ZDB-GENE-030721-7	Length:	626	Species:	Danio rerio

Alignment Length:	660	Identity:	147/660 - (22%)
Similarity:	265/660 - (40%)	Gaps:	152/660 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 EKMEKENRELRQQYLILKTNKKTTAKKIKKSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQ 308
            :..|.|...|.|.|          .||: :.:||:    :|.|..  .|.....:||.:.|:|||
Zfish     5 DSAEGECNGLNQHY----------EKKV-RPIIDL----VDTLRA--LGVEKDLNLPAIAVIGDQ 52

  Fly   309 SSGKTSVLESIAKARIFPRGSGEMMTRAPV-----KVTLAEGPYHVAQFRDSDREYDLTKESDLQ 368
            ||||:||||:::...: |||.| ::||.|:     |:|           ||.:....||.:...:
Zfish    53 SSGKSSVLEALSGVAL-PRGIG-IVTRCPLILKLKKIT-----------RDKNWSGLLTYKDQTE 104

  Fly   369 DLRRDVEFR---MKASVR---GGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKD 427
            .|:......   :||.:.   .|:.:|:|:|.:.::...:..:.|:|||||....|.:...|.:.
Zfish   105 ILKEPTGIENAVLKAQIALAGTGEGISHEMITLEIQSCDVPDLTLIDLPGIARVATGNQPEDIEK 169

  Fly   428 SIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRI 492
            .|..:.:.::.....|.|.:...::|...:....:....||.|:||:.:|||.||.:...:...:
Zfish   170 QIKDLIEKFIKRQETISLVVVPANIDIATTEALKMASTVDPTGQRTLCILTKPDLVDRGMEDTVV 234

  Fly   493 RKILSGKLFPMKALGYYAVVTGRGRKD--DSIDAIRQYEED--FFKNSKLFHRRGVIMPHQVTSR 553
            |.:.:..:...|.   |.:|..||::|  |.::.:...|::  ||.....|  ..::...:.|..
Zfish   235 RTVNNEVIRLEKG---YMIVKCRGQQDINDKLNLVEALEKERRFFDEHPQF--SSLLEDGKATIP 294

  Fly   554 NLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDELFDKAKGEIL--DEV 616
            .|.       .::..|.:|..|......:..:|.:.:..|.||          |..||.:  |:.
Zfish   295 LLG-------QRLTEELVEHIAKNVPRLQNQIEMKLQKTFERL----------KVLGESVPDDDE 342

  Fly   617 VTLSQISAKK---WDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSFNTMVDIKLRQ----WAEQ 674
            :.|:....||   :.|||     |::.....|.:           ..:|.|..|:||    | :.
Zfish   343 IELNNFLIKKLRQFMDAL-----EEVKRVEEEPV-----------KSDTRVFSKIRQEFVSW-KH 390

  Fly   675 ALPAKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAVVDEAIRRH--SWEDKAIDMLRVI 737
            .|.:|.::...:.  ||::    |:.:.::..|..:....|.:   ||.|  ..|:.|:.:||
Zfish   391 ILDSKPIKMSTDL--QEYV----RTHRGKELPGFLNYGTFAGI---IRMHVEDLEEPALKLLR-- 444

  Fly   738 QLNTLEDRFVHDKQEWDSAVKFLESSVNA-----------KLVQTEETLAQMFGPGQMRRITHWQ 791
                             :|...:.|||.:           .|:..:|.:         .:..|.|
Zfish   445 -----------------NAKDIVHSSVGSIANIHFNGYPNLLLAVKEPI---------EKCLHEQ 483

  Fly   792 YLTQDQQKRRSVKNELDKILKND--TKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFPVYR 854
            :...:::.|...|.|.....::|  |.||..|.  ...|||..|:   ..:....:|:|.|  :.
Zfish   484 FQNAEEKIRSQFKLEKTVYCQDDLYTNHLNLLR--PKNTVRFGLE---ASLGNSELRETAF--HL 541

  Fly   855 KHFLQQALQR 864
            ..:|..|.:|
Zfish   542 TSYLTIACER 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	71/288 (25%)
mxc	NP_001007285.1	DLP_1	41..313	CDD:206738	73/296 (25%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	50..57		6/6 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	75..77		0/1 (0%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	151..154		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	220..223		2/2 (100%)
		Dynamin_M	234..516	CDD:279383	68/357 (19%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	252..255		0/2 (0%)
		GED	532..619	CDD:280391	6/22 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900