DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and DNM3

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_016856465.1	Gene:	DNM3 / 26052	HGNCID:	29125	Length:	921	Species:	Homo sapiens

Alignment Length:	806	Identity:	180/806 - (22%)
Similarity:	324/806 - (40%)	Gaps:	172/806 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||.:.:.:.|..|.  .|.:....||::.|||.||:||:||||:.......||||| ::||.|
Human     7 EELIPLVNRLQDAFSA--LGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-IVTRRP 68

  Fly   338 VKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGL 402
            :.:.|.......|:|.....:    |.:|..::|.::|..........|.:|:..|.:.|..|.:
Human    69 LVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRLEIEAETDRVTGMNKGISSIPINLRVYSPHV 129

  Fly   403 QRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCD 467
            ..:.|:|||||......|...|.:..|.:|...:::..|.:||.:...:.|...|:...|..:.|
Human   130 LNLTLIDLPGITKVPVGDQPPDIEYQIREMIMQFITRENCLILAVTPANTDLANSDALKLAKEVD 194

  Fly   468 PLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD----DSIDAIRQY 528
            |.|.|||.|:||:||.:|..|   .|.:|..||.|::. ||..|| .|.:||    ..|.|....
Human   195 PQGLRTIGVITKLDLMDEGTD---ARDVLENKLLPLRR-GYVGVV-NRSQKDIDGKKDIKAAMLA 254

  Fly   529 EEDFFKNSKLFH----RRGVIMPHQVTSRNLSLAVSDRFWKMVRET--------------IEQQA 575
            |..||.:...:.    |.|.  ||      |...::.:....:|:|              ||.:.
Human   255 ERKFFLSHPAYRHIADRMGT--PH------LQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEV 311

  Fly   576 DAFK------ATR-----FNLETEWKNNFPRLRESGRD-----ELFDKAK-GEILDEVVTLSQIS 623
            :|:|      .||     ..:..::..:|.:..|...|     ||...|| ..|..|......:.
Human   312 EAYKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVK 376

  Fly   624 AKKWDDALSTKLWEKLSNYVFESIYLPAAQSG---SQNSFNTMVD---IKLRQWAEQALPA-KSV 681
            .:..:..|..::     :|..::|:  ..::|   ...:|..:|.   :||:.      |: |||
Human   377 MEFNEKELRREI-----SYAIKNIH--GIRTGLFTPDMAFEAIVKKQIVKLKG------PSLKSV 428

  Fly   682 EAGWEALQQEFISLMER-SKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDM------LRVIQL 739
                :.:.||.|:.::: :||..:...:.::.:..|.:....|   |.|..|.      ::|..:
Human   429 ----DLVIQELINTVKKCTKKLANFPRLCEETERIVANHIRER---EGKTKDQVLLLIDIQVSYI 486

  Fly   740 NTLEDRF------------VHDKQEWDSAVKFLESS---VNAKLVQTEETLAQMFGPGQMRRITH 789
            ||..:.|            ||.|....:....|..|   |..|...|...:..|.|..:    .:
Human   487 NTNHEDFIGFANAQQRSSQVHKKTTVGNQGTNLPPSRQIVIRKGWLTISNIGIMKGGSK----GY 547

  Fly   790 WQYLTQDQ---QKRRSVKNELDKILKNDTKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFP 851
            |..||.:.   .|...:.::.. :|.:..:..|.|.|:    :..| ||....::: |..|..||
Human   548 WFVLTAESLSWYKDDEIPSQTG-LLPDLQQGFPLLPHE----IYSN-QRCKEHLNS-YFLQEVFP 605

  Fly   852 VY-------RKHFLQQALQRAKDCRKAY----YLYTQQGAE----------CEISC--SDVVLFW 893
            .:       :|:.|.....:.:|..|::    :::.....|          .|::|  .:.|..|
Human   606 DHLQLKEKEKKYMLPLDNLKVRDVEKSFMSSKHIFALFNTEQRNVYKDYRFLELACDSQEDVDSW 670

  Fly   894 RIQQV------IKITGNALRQQVINREAR------RLDKEIKAV---LDEFSDDEEKKGYLLTGK 943
            :...:      .|..||...:...|.:|.      :|:::::.:   :|.:..        :..|
Human   671 KASLLRAGVYPDKSVGNNKAENDENGQAENFSMDPQLERQVETIRNLVDSYMS--------IINK 727

  Fly   944 --RVLLAEELIKVRQIQEKLEEFINS 967
              |.|:.:.::.:  :...:::||||
Human   728 CIRDLIPKTIMHL--MINNVKDFINS 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	86/295 (29%)
DNM3	XP_016856465.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810