Protein Alignment Opa1 and Dnm2

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_037331.1
• Gene: Dnm2 / 25751
• RGDID: 2513
• Length: 870
• Species: Rattus norvegicus
• Alignment Length: 722
• Identity: 159/722 - (22%)
• Similarity: 298/722 - (41%)
• Gaps: 130/722 - (18%)

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||.:.:::.|..|  ..|.:....||::.|||.||:||:||||:.......||||| ::||.|
  Rat     7 EELIPLVNKLQDAFS--SIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-IVTRRP 68

  Fly   338 VKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGL 402
            :.:.|.......|:|.....:    |.:|..::|:::|..........|.:|...|.:.|..|.:
  Rat    69 LILQLIFSKTEYAEFLHCKSK----KFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHV 129

  Fly   403 QRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCD 467
            ..:.|:|||||......|...|.:..|..|...::|..:::||.:...::|...|:...|..:.|
  Rat   130 LNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVD 194

  Fly   468 PLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTG-----RGRKDDSIDAIRQ 527
            |.|.|||.|:||:||.:|..|   .|.:|..||.|::. ||..||..     .||||  |.|...
  Rat   195 PQGLRTIGVITKLDLMDEGTD---ARDVLENKLLPLRR-GYIGVVNRSQKDIEGRKD--IRAALA 253

  Fly   528 YEEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLE---TEW 589
            .|..||.:...:..    |..::.:.:|...::.:....:||::.......::...:||   .|:
  Rat   254 AERKFFLSHPAYRH----MADRMGTPHLQKTLNQQLTNHIRESLPTLRSKLQSQLLSLEKEVEEY 314

  Fly   590 KNNFP------------RLRESGRDELFDKAKGEILDEVVTLS-----------------QISAK 625
            ||..|            .:::.|.|  |:|......|:|.||.                 ::...
  Rat   315 KNFRPDDPTRKTKALLQMVQQFGVD--FEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKM 377

  Fly   626 KWDDALSTKLWEKLSNYVFESIYLPAAQSG---SQNSFNTMVDIKLRQWAEQALPAKSVEAGWEA 687
            ::|:    |...:..:|..::|:  ..::|   ...:|..:|..::.:..|..|  |.|    :.
  Rat   378 EFDE----KDLRREISYAIKNIH--GVRTGLFTPDLAFEAIVKKQVVKLKEPCL--KCV----DL 430

  Fly   688 LQQEFISLMER-SKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDMLRVIQLNTLEDRFVHDKQ 751
            :.||.||.:.: :.|...:..:.::.: .:|...||......|.    :::.|..:|..:::...
  Rat   431 VIQELISTVRQCTSKLSSYPRLREETE-RIVTTYIREREGRTKD----QILLLIDIEQSYINTNH 490

  Fly   752 EWDSAVKFLESSVNAKLVQTEETLAQMFGPGQ-----MRR--IT-------------HWQYLT-- 794
            |  ..:.|..:...:..:..:..:     |.|     :||  :|             :|..||
  Rat   491 E--DFIGFANAQQRSTQLNKKRAI-----PNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAE 548

  Fly   795 ------QDQQKRRSVKNELDKILKND-------TKHLPTLTHDELTTVRKNLQRDNVDVDTDYIR 846
                  .:::|.:.....||.:...|       .||:..:.:.|...|.|:|::..:..|:....
  Rat   549 SLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDV 613

  Fly   847 QTWFPVYRKHFLQQALQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVI 911
            .:|    :..||:..:...||..:     .:.||:......|..|..:::.:..:..:.:  .:|
  Rat   614 DSW----KASFLRAGVYPEKDQAE-----NEDGAQENTFSMDPQLERQVETIRNLVDSYV--AII 667

  Fly   912 NREARRL 918
            |:..|.|
  Rat   668 NKSIRDL 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	84/278 (30%)
		OPA1_C	629..972	CDD:466080	55/329 (17%)
Dnm2	NP_037331.1	DYNc	6..245	CDD:197491	76/248 (31%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	38..45		4/6 (67%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	64..66		0/1 (0%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	136..139		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	205..208		2/2 (100%)
		Dynamin_M	215..502	CDD:460033	61/317 (19%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	235..238		1/2 (50%)
		PH_dynamin	520..629	CDD:269958	20/112 (18%)
		GED	649..739	CDD:460495	5/28 (18%)
		PHA03247	<737..868	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..870