Protein Alignment Opa1 and dnm1

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_596014.1
• Gene: dnm1 / 2540159
• PomBaseID: SPBC12C2.08
• Length: 781
• Species: Schizosaccharomyces pombe
• Alignment Length: 847
• Identity: 176/847 - (20%)
• Similarity: 315/847 - (37%)
• Gaps: 225/847 - (26%)

  Fly   273 KSLIDMYSEVLDELSGYDT-GYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRA 336
            :.||.:.:::.|.:  |:| |....| ||.:||||.||.||:||||:|......|||:| ::||.
pombe     2 EQLIPLVNQLQDLV--YNTIGSDFLD-LPSIVVVGSQSCGKSSVLENIVGKDFLPRGTG-IVTRR 62

  Fly   337 PV-------------------------KVTLAEGPYHVAQ--FRDSDREYDL--------TKESD 366
            |:                         :.|.|.|.....:  ..|||...|.        ||.:|
pombe    63 PLILQLINLKRKTKNNHDEESTSDNNSEETSAAGETGSLEGIEEDSDEIEDYAEFLHIPDTKFTD 127

  Fly   367 LQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQ 431
            :..:|.::|..........|.::...|.:.:....:..:.|:||||:......|..:|.:.....
pombe   128 MNKVRAEIENETLRVAGANKGINKLPINLKIYSTRVLNLTLIDLPGLTKIPVGDQPTDIEAQTRS 192

  Fly   432 MTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKIL 496
            :...|:|.||:|||.:...:.|...|....|....||.|:|||.||||:||.::   ......||
pombe   193 LIMEYISRPNSIILAVSPANFDIVNSEGLKLARSVDPKGKRTIGVLTKLDLMDQ---GTNAMDIL 254

  Fly   497 SGKLFPMKALGYYAVVTGRGRKD-----DSIDAIRQYEEDFFKNSKLFH----RRGVIMPHQV-T 551
            ||:::|:| ||:.|.| .|.:.|     ...||: |.|..||::...:.    |.|.  |:.. |
pombe   255 SGRVYPLK-LGFVATV-NRSQSDIVSHKSMRDAL-QSERSFFEHHPAYRTIKDRCGT--PYLAKT 314

  Fly   552 SRNLSLA--------VSDRFWKMVRETIEQQADAFKATRFNLETEW------------------- 589
            ..||.::        :..|...::.:| :||.:.:...:.:.:::.
pombe   315 LSNLLVSHIRERLPDIKARLSTLISQT-QQQLNNYGDFKLSDQSQRGIILLQAMNRFANTFIASI 378

  Fly   590 ---KNNFPRLRESGRDEL---FDKAKGEILDEVVTLSQISAKKWDDALSTKLWEK----LSNYVF 644
               .:|.|....||...|   |:......|:.:..|..:|......|:......:    ||...|
pombe   379 DGNSSNIPTKELSGGARLYSIFNNVFTTALNSIDPLQNLSTVDIRTAILNSTGSRATLFLSEMAF 443

  Fly   645 ESIYLPAAQ-----------------------SGS---------QNSFNTMVDIKLRQWAEQALP 677
            :.:..|...                       ||.         |.:....|...||   |...|
pombe   444 DILVKPQLNLLAAPCHQCVELVYEELMKICHYSGDSDISHFPKLQTALVETVSDLLR---ENLTP 505

  Fly   678 AKSVEAGWEALQQEFIS---------------LMERSKK-----AQDHDGIFDQLKSAVVDEAIR 722
            ..|......|:|..:|:               ::.|.::     :|::|.........|..:.|.
pombe   506 TYSFVESLIAIQSAYINTNHPDFLGVQGAMAVVLSRKEQNRLMLSQENDEPISSALDTVKPDGIE 570

  Fly   723 RHSWED----KAIDMLRVIQLNTLEDRFVHDKQEWD-SAVKFLESSVNAKLVQTEETLAQMFGPG 782
            .:|.:.    |:|......::.||:.......|..| .|.|...::.:.:..:.:..|:.:||..
pombe   571 LYSSDPDTSVKSITNKATNEITTLKSDDSAKMQPLDVLASKRYNNAFSTETAERKTFLSYVFGAN 635

  Fly   783 QMRRITHWQYLTQDQQKRRSVKNELDKILKNDTKH-------LPTLTHDELTTVRKNL-QRDNVD 839
            ...|    :.::.|:.....:.   |.:...||.|       :..|:::..|...::: :|:.|:
pombe   636 NATR----KAMSIDKSSSYPLN---DSLSGGDTNHKNNHPLKMTDLSNEVETMALEDMSEREEVE 693

  Fly   840 VDTDYIRQTWFPVYRKHFLQQALQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVI-KITG 903
            ||.                      .|:...:|:..|::           ::..::.:|| .:..
pombe   694 VDL----------------------IKELITSYFNLTRK-----------IIIDQVPKVIMHLLV 725

  Fly   904 NALRQQVINREARRLDKEIKAVLDEFSDDEEKKGYLLTGKRVLLAEELIKVRQIQEKLEEFINSL 968
            ||.:..:.||...:|.:|      :|.|            .:|:.:|  .|:..:||.|..::..
pombe   726 NASKDAIQNRLVSKLYRE------DFFD------------TLLIEDE--NVKSEREKCERLLSVY 770

  Fly   969 NQ 970
            ||
pombe   771 NQ 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	91/326 (28%)
		OPA1_C	629..972	CDD:466080	67/412 (16%)
dnm1	NP_596014.1	DLP_1	24..328	CDD:206738	90/313 (29%)
		Dynamin_M	249..536	CDD:460033	54/295 (18%)
		GED	690..780	CDD:460495	24/136 (18%)