DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and msp1

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_596452.1	Gene:	msp1 / 2539844	PomBaseID:	SPBC1718.06	Length:	903	Species:	Schizosaccharomyces pombe

Alignment Length:	997	Identity:	211/997 - (21%)
Similarity:	368/997 - (36%)	Gaps:	257/997 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 AGNPARGWQMPPPSRGYGMLVVRILRGALKLRYIVLGGAIGGGVSLSKKYEEWKDGLPNFKWLED 126
            :.|..|.:.....||    ||.|.||..:....:|.|||...|..:.:..:..||.......:.|
pombe    64 SANTVRFFSFSSISR----LVFRSLRLPVAGFSLVAGGAAYIGAQVQRASDYTKDIFDKTFGILD 124

  Fly   127 AMPQGERWSQFSRNLIEVGSLVKNAIEVDPKLKQLGEDKLSEWRNWFDSRLDDAIEAADYQGVQI 191
            :     .|.:....:..|.::            ||.|..:..|.... .|||:  |:|:.:.|..
pombe   125 S-----TWEKTRETVASVTNV------------QLPEISMPLWLEKI-LRLDE--ESAERRRVLQ 169

  Fly   192 VE---------------TKDDLKAKTTVAALGITSDESRKKYEKLQSQVETLQTEIMNVQIKYQK 241
            .|               :.:|.....|...:|.....|....:.:..: :||..:
pombe   170 AERAKEHRSNSNDKQKSSDNDEDPNDTTVGIGAALAASILSVDSVDGE-DTLTAD---------- 223

  Fly   242 ELEKMEKENRELRQQYLILKTNKKTTAKKIKKSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVG 306
            |..|:.:|::|.|   ::|.|.|....:.|.:.:.|..|.|.               ||.:||:|
pombe   224 EKRKLAQESKEDR---MMLFTKKMIEIRNILQDIQDNNSAVT---------------LPSIVVIG 270

  Fly   307 DQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTLAEGPYHVAQFRDSDREYD------LTKES 365
            .|||||:||||:|......|:|| .|:||.|:::||.    |.|.......|:.      :|..|
pombe   271 SQSSGKSSVLEAIVGHEFLPKGS-NMVTRRPIELTLV----HSADTAIPYGEFSGVQLGKITDFS 330

  Fly   366 DLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIH 430
            .:|.:..|:...:.:|    :.|.:..|.:|:....:..:.|:||||.|...:.|..:|....|.
pombe   331 KIQHILTDLNMAVPSS----QGVDDNPIRLTIYASHIPNLSLIDLPGYIQIHSEDQPADLDMKIS 391

  Fly   431 QMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKI 495
            ::.:.|:..|| |||.:....||...|.......:.||||.|||.|:||:|    |..|.:...|
pombe   392 KLCEKYIREPN-IILAVCAADVDLANSAALRASRRVDPLGLRTIGVVTKMD----LVPPSKAISI 451

  Fly   496 LSGKLFPMKALGYYAVV-----TGRGRKDDSI-DAIRQYEEDFFKNSKLFH-------------R 541
            |....:|:. .||..|:     |||.....:: |.:...|..:|...:.|.             |
pombe   452 LHNNNYPLH-YGYIGVISRIVPTGRFSAGQNLTDLVSTQENSYFSTHQQFADARIGNYLGIQSLR 515

  Fly   542 RGVIMPHQVT-SRNLSLAVSDRFWKMVRETIEQ--------------QADAFKATRFNLETEWKN 591
            :.:|...:.| |:||......     :|..:|:              .||::.|...::   :|.
pombe   516 KCLINVLEYTMSKNLQHTADS-----IRTELEECNYQYKVQYNDRVLTADSYIAEGLDI---FKA 572

  Fly   592 NFPRLRES-GRDELFDKAKGEILDEVVTLSQISAKKW-DDALSTKLWEKLSN-------YVFESI 647
            .|....:. |:.|:.|..|..:.::|:.|  ::.:.| ||.:|.  |.|.:|       |..:|.
pombe   573 AFKEFTQKFGKSEVRDLLKSSLNEKVMDL--LAERYWTDDDISN--WSKHTNALDEHWKYKLDSC 633

  Fly   648 YLPAAQSGSQNSFNTMVDIKLRQWAEQALPAKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQL 712
            .....:.|.......:|...:.:..::                     :.::....||......:
pombe   634 VSTLTRMGLGRVSTLLVTDSISKCIDE---------------------ITKASPFADHPAAMQYI 677

  Fly   713 KSAVVDEAIRR-HSWEDKAIDMLRVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTE---- 772
            .:|..|...|| |:..::..:.::..:.    |..|:| .||.|:....|     ||:|.|
pombe   678 MNAAQDILRRRFHATSEQVENCVKPYKY----DVEVND-DEWKSSRGQAE-----KLLQRELGLC 732

  Fly   773 ----ETLAQMFGPGQMRRITHWQYLTQDQQKRRSVKNELDKILKNDTKHLPTLTHDELTTVRKNL 833
                |.:....|..:|.::.  |||.:.               |..::.||......|....:.|
pombe   733 QSALEKIKNAVGSRRMNQVL--QYLEEQ---------------KTSSEPLPASYSTALLEQGRML 780

  Fly   834 QRDNVDVDTDYIRQTWFPVYRKHFLQQALQ--RAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQ 896
            |         |::.      |:..|:..:.  :::.|:.         .|.:.:|.::.|
pombe   781 Q---------YLKM------REDILKLRISVLKSRACKH---------KEAKYTCPEIFL----- 816

  Fly   897 QVIKITGNALRQQVINREARRLDKEIKAVLDEF---------------SDDEEKKGYLLTGKRVL 946
                   ||:..:::|.....::.|:   |.||               ...|:...::....|:.
pombe   817 -------NAVSDKLVNTAVLFINIEL---LSEFYYQFPRELDQRLIHSLSSEQLNAFVNENPRLK 871

  Fly   947 LAEELIKVRQIQEKLEEFINSL 968
            ...:|...||..|...:.||||
pombe   872 SQLQLQHKRQCLELALQKINSL 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	86/299 (29%)
msp1	NP_596452.1	CrfC	156..851	CDD:223771	178/839 (21%)
msp1	NP_596452.1	DLP_1	261..522	CDD:206738	82/290 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11566
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000