DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and Mx1

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_001257987.1	Gene:	Mx1 / 24575	RGDID:	3127	Length:	652	Species:	Rattus norvegicus

Alignment Length:	686	Identity:	153/686 - (22%)
Similarity:	289/686 - (42%)	Gaps:	136/686 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 TNKKTTAKKIKKSLIDMYSE-------VLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESI 319
            |::::.|.:...:|...|.|       ::|.|........:|  ||.:.|:|||||||:||||::
  Rat    19 TSEESQAMESVDNLCSQYEEKVRPCIDLIDSLRALGVEQDLA--LPAIAVIGDQSSGKSSVLEAL 81

  Fly   320 AKARIFPRGSGEMMTRAPVKV---TLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKAS 381
            :...: ||||| ::||.|:.:   .|.:|.....:....|.|.:::..|.::   |::.......
  Rat    82 SGVAL-PRGSG-IVTRCPLVLKLKQLKQGEKWSGKVIYKDTEIEISHPSLVE---REINKAQNLI 141

  Fly   382 VRGGKTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILC 446
            ...|..:|:::|::.|..|.:..:.|:|||||......|..:|.:..|.::...|:.....|.|.
  Rat   142 AGEGLKISSDLISLEVSSPHVPDLTLIDLPGITRVAVGDQPADIEHKIKRLITEYIQKQETINLV 206

  Fly   447 IQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAV 511
            :...:||...:....:..:.||.|.|||.:|||.||.:. ...|::..::...:..:|.  .|.:
  Rat   207 VVPSNVDIATTEALKMAQEVDPQGDRTIGILTKPDLVDR-GTEDKVVDVVRNLVCHLKK--GYMI 268

  Fly   512 VTGRGRKDD----SIDAIRQYEEDFFKNSKLFHRRGVIMPHQVT----SRNLSLAVSDRFWKMVR 568
            |..||::|.    |:....|.|:.|||....|  |.::...:.|    ::.|::.::....|.:
  Rat   269 VKCRGQQDIQEQLSLAEALQKEQVFFKEHPQF--RVLLEDGKATVPCLAKRLTMELTSHICKSL- 330

  Fly   569 ETIEQQADAFKATRFNLETEWKNNFPRLRESGRD----------------ELFDKAKGEILDEVV 617
            ..:|.|.:    ....:.:|      .|::.|.|                .:|:|   :||..|.
  Rat   331 PILENQIN----VNHQIASE------ELQKYGADIPEDDSKRLSFLMNKINVFNK---DILSLVQ 382

  Fly   618 TLSQISAKKWDDALSTKLWEKLSN-------YVFESI--YLPAAQSGSQ-NSFNT---------M 663
            ....||   |::   ::|:.||.|       |:.|..  .|.:::..|| ..|.:         .
  Rat   383 AQENIS---WEE---SRLFTKLRNEFLAWNDYIEEHFKKTLGSSEKHSQMEKFESHYRGRELPGF 441

  Fly   664 VDIKLRQWAEQALPAKSVEAGWEALQQEFISLMER---------SKKAQDHDGIFDQL----KSA 715
            ||.|    |.:.:..|.|    :||::..::::.|         :|.:.::.|.|..|    ||.
  Rat   442 VDYK----AFENIIKKEV----KALEEPALNMLHRVTTMVKNAFTKVSSNNFGDFLNLHSTAKSK 498

  Fly   716 VVDEAIRRHSWEDKAIDMLRVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFG 780
            :.|   .|.|.|.:|..::|      |..:..|.....|.|.|.....:..|..:.|::...:|.
  Rat   499 IED---IRFSQEKEAEKLIR------LHFQMEHIVYCQDQAYKKALKEIREKEAEKEKSTFGVFQ 554

  Fly   781 PGQMRRITHWQYLTQD-----QQKRRSVKNELDKILKNDTKHLPTLTHDELTTVRKNLQRDNVDV 840
            ....|:......:||.     |:..|::..::..|::          :..|.|..:.:::..:.:
  Rat   555 QNSPRKELTTTEMTQHLNAYYQECGRNIGRQIPLIIQ----------YSILQTFGQEMEKAMLQL 609

  Fly   841 DTDYIRQTWFPV------YRKHFLQQALQRAKDCRK 870
            ..|..:..||..      .:|.||::.|.|..:.::
  Rat   610 LQDTSKCNWFLTEQSDSREKKKFLKRRLLRLDEAQR 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	76/284 (27%)
Mx1	NP_001257987.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		2/7 (29%)
		DLP_1	59..331	CDD:206738	77/284 (27%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	68..75		6/6 (100%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	93..95		0/1 (0%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	169..172		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	238..241		2/2 (100%)
		Dynamin_M	251..540	CDD:395818	67/329 (20%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	270..273		0/2 (0%)
		Bundle signaling element (BSE). /evidence=ECO:0000250	332..357		6/34 (18%)
		Middle domain. /evidence=ECO:0000250	357..526		41/194 (21%)
		Stalk. /evidence=ECO:0000250	358..622		58/299 (19%)
		GED	559..650	CDD:128597	16/97 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900