DRSC/TRiP Functional Genomics Resources

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Protein Alignment Opa1 and Mfn1

DIOPT Version :9

Sequence 1:NP_725369.1 Gene:Opa1 / 36578 FlyBaseID:FBgn0261276 Length:972 Species:Drosophila melanogaster
Sequence 2:NP_620432.1 Gene:Mfn1 / 192647 RGDID:621460 Length:741 Species:Rattus norvegicus


Alignment Length:807 Identity:164/807 - (20%)
Similarity:272/807 - (33%) Gaps:256/807 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   283 LDELSGYDT-----GYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTL 342
            |.|:.||..     |..::....:|...|..||||:||:.::...::.|.|.|. .|...:.|  
  Rat    54 LVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGH-TTNCFLSV-- 115

  Fly   343 AEGPYHVAQFRDSDREYDLTKESDLQDLRRDVE-----FRMKASVRGGKTVSNEVIAMTVKGPGL 402
             ||       .|.|:.|.:|:.||.:...:.|.     ..|...::.|..|  .|.....|...|
  Rat   116 -EG-------TDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLV--HVFWPKAKCALL 170

  Fly   403 Q-RMVLVDLPGIISTMTVD--------------MASDTKDSIHQMTKHY-------MSNPNAIIL 445
            : .:||||.||...|..:|              :.::::.::....||:       :|.||..||
  Rat   171 RDDLVLVDSPGTDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFIL 235

  Fly   446 CIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRI-----RKILSGKLFPMKA 505
            ..:..:..:|...:.|:..|  .:.|...|::.::.:...|...:||     :::|:.::  .||
  Rat   236 NNRWDASASEPEYMEDVRRQ--HMERCLHFLVEELKVVSPLEARNRIFFVSAKEVLNSRM--NKA 296

  Fly   506 LGYYAVVTGRGRKDDSIDAIRQ--------YEEDFFKNS-KLFHRRGVIMPHQV--TSRNL---- 555
            .|   :..|.|...:...|..|        :||...::: |....:..|...|:  |.:|:    
  Rat   297 QG---MPEGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSV 358

  Fly   556 -SLAVSDRFWKMVRETIEQQADA--FKATRFNLET-EWKNNFPRLRESGRDELFDKAKGEILDEV 616
             ..|...|.:.|  |..|.|.|.  |...:.||.| :.|.....:.|    |:.:|....:.||:
  Rat   359 NVAAAEKRVYSM--EEREDQIDRLDFIRNQMNLLTMDVKKKIKEVTE----EVANKVSCAMTDEI 417

  Fly   617 VTLSQI---------------------SAKKWDDALSTKLWEKLSNYVFESI----------YLP 650
            ..||.:                     ..|..:|.:...|.::.::.|..||          ..|
  Rat   418 CRLSVLVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTSEVNASILQSQQEIIENLKP 482

  Fly   651 AAQSGSQNSFNTMVDIK-------------LRQWAEQALPAKSVEAGWEALQQEFISLMERSKKA 702
            ...:|.||..:|::..|             ...:.|..:...|:  ||.:|...|:.    |..|
  Rat   483 LLPAGIQNKLHTLIPCKKFDLSYDLNCHKLCSDFQEDIVFRFSL--GWSSLVHRFLG----STNA 541

  Fly   703 QD-----HDGIFDQLKS-----------AVVDEAIRRHSWEDKAIDMLRVIQLNTLEDR-----F 746
            |.     .:.||...:|           |..|.|.:    |:..|.:  :..|.:|..|     .
  Rat   542 QRVLLGLSEPIFQVPRSLASTPTAPSNPAAPDNAAQ----EELMITL--ITGLASLTSRTSMGII 600

  Fly   747 VHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLTQDQQKRRSVKNELDKIL 811
            |.....|        .:|..||:..  ||: |:|.         .||                  
  Rat   601 VVGGVIW--------KTVGWKLISV--TLS-MYGA---------LYL------------------ 627

  Fly   812 KNDTKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFP-VYRKHFLQQALQRAKDCRKAYYLY 875
                                            |.|.||.. ...:.|.||.:..|.:..:....:
  Rat   628 --------------------------------YERLTWTTRAKERAFKQQFVNYATEKLQMIVKF 660

  Fly   876 TQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVINREARRLDKEIKAVLDEFSDDEEK---KG 937
            |......::.......|.|:.|.:.:|     |:.:..|..||.|||        |..||   ..
  Rat   661 TSANCSHQVQQEMATTFARLCQQVDVT-----QKHLEEEIARLSKEI--------DQLEKIQNNS 712

  Fly   938 YLLTGKRVLLAEELIKVRQIQEKLEEF 964
            .||..|.|          |::.:||.|
  Rat   713 KLLRNKAV----------QLERELENF 729

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Opa1NP_725369.1 DLP_1 298..572 CDD:206738 70/321 (22%)
Mfn1NP_620432.1 Part of a helix bundle domain, formed by helices from N-terminal and C-terminal regions. /evidence=ECO:0000250|UniProtKB:Q8IWA4 9..73 5/18 (28%)
DLP_2 76..328 CDD:206739 61/271 (23%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 82..89 4/6 (67%)