Protein Alignment Opa1 and DNM2

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: NP_001005360.1
• Gene: DNM2 / 1785
• HGNCID: 2974
• Length: 870
• Species: Homo sapiens
• Alignment Length: 721
• Identity: 157/721 - (21%)
• Similarity: 298/721 - (41%)
• Gaps: 128/721 - (17%)

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||.:.:::.|..|  ..|.:....||::.|||.||:||:||||:.......||||| ::||.|
Human     7 EELIPLVNKLQDAFS--SIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-IVTRRP 68

  Fly   338 VKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGL 402
            :.:.|.......|:|.....:    |.:|..::|:::|..........|.:|...|.:.|..|.:
Human    69 LILQLIFSKTEHAEFLHCKSK----KFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHV 129

  Fly   403 QRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCD 467
            ..:.|:|||||......|...|.:..|..|...::|..:::||.:...::|...|:...|..:.|
Human   130 LNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVD 194

  Fly   468 PLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD----DSIDAIRQY 528
            |.|.|||.|:||:||.:|..|   .|.:|..||.|::. ||..|| .|.:||    ..|.|....
Human   195 PQGLRTIGVITKLDLMDEGTD---ARDVLENKLLPLRR-GYIGVV-NRSQKDIEGKKDIRAALAA 254

  Fly   529 EEDFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLE---TEWK 590
            |..||.:...:..    |..::.:.:|...::.:....:||::.......::...:||   .|:|
Human   255 ERKFFLSHPAYRH----MADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYK 315

  Fly   591 NNFP------------RLRESGRDELFDKAKGEILDEVVTLS-----------------QISAKK 626
            |..|            .:::.|.|  |:|......|:|.||.                 ::...:
Human   316 NFRPDDPTRKTKALLQMVQQFGVD--FEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKME 378

  Fly   627 WDDALSTKLWEKLSNYVFESIYLPAAQSG---SQNSFNTMVDIKLRQWAEQALPAKSVEAGWEAL 688
            :|:    |...:..:|..::|:  ..::|   ...:|..:|..::.:..|..|  |.|    :.:
Human   379 FDE----KDLRREISYAIKNIH--GVRTGLFTPDLAFEAIVKKQVVKLKEPCL--KCV----DLV 431

  Fly   689 QQEFISLMER-SKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDMLRVIQLNTLEDRFVHDKQE 752
            .||.|:.:.: :.|...:..:.::.: .:|...||......|.    :::.|..:|..:::...|
Human   432 IQELINTVRQCTSKLSSYPRLREETE-RIVTTYIREREGRTKD----QILLLIDIEQSYINTNHE 491

  Fly   753 WDSAVKFLESSVNAKLVQTEETLAQMFGPGQ-----MRR--IT-------------HWQYLT--- 794
              ..:.|..:...:..:..:..:     |.|     :||  :|             :|..||
Human   492 --DFIGFANAQQRSTQLNKKRAI-----PNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAES 549

  Fly   795 -----QDQQKRRSVKNELDKILKND-------TKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQ 847
                 .:::|.:.....||.:...|       .||:..:.:.|...|.|:|::..:..|:.....
Human   550 LSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVD 614

  Fly   848 TWFPVYRKHFLQQALQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVIN 912
            :|    :..||:..:...||..:     .:.||:......|..|..:::.:..:..:.:  .:||
Human   615 SW----KASFLRAGVYPEKDQAE-----NEDGAQENTFSMDPQLERQVETIRNLVDSYV--AIIN 668

  Fly   913 REARRL 918
            :..|.|
Human   669 KSIRDL 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	83/277 (30%)
		OPA1_C	629..972	CDD:466080	54/329 (16%)
DNM2	NP_001005360.1	DYNc	6..245	CDD:197491	79/249 (32%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	38..45		4/6 (67%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	64..66		0/1 (0%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	136..139		2/2 (100%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	205..208		2/2 (100%)
		Dynamin_M	215..502	CDD:460033	59/316 (19%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055	235..238		1/3 (33%)
		PH_dynamin	520..629	CDD:269958	20/112 (18%)
		GED	649..739	CDD:460495	5/28 (18%)
		PHA03247	<737..868	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	741..870