DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and DNM1

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_001361198.1	Gene:	DNM1 / 1759	HGNCID:	2972	Length:	867	Species:	Homo sapiens

Alignment Length:	766	Identity:	168/766 - (21%)
Similarity:	327/766 - (42%)	Gaps:	103/766 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||.:.:.:.|..|.  .|......||::.|||.||:||:||||:.......||||| ::||.|
Human     7 EDLIPLVNRLQDAFSA--IGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-IVTRRP 68

  Fly   338 VKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGL 402
            :.:.|.......|:|.....:    |.:|.:::|.::|..........|.:|...|.:.|..|.:
Human    69 LVLQLVNATTEYAEFLHCKGK----KFTDFEEVRLEIEAETDRVTGTNKGISPVPINLRVYSPHV 129

  Fly   403 QRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCD 467
            ..:.||||||:......|...|.:..|..|...:::..|.:||.:...:.|...|:...:..:.|
Human   130 LNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVD 194

  Fly   468 PLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD----DSIDAIRQY 528
            |.|:|||.|:||:||.:|..|   .|.:|..||.|::. ||..|| .|.:||    ..|.|....
Human   195 PQGQRTIGVITKLDLMDEGTD---ARDVLENKLLPLRR-GYIGVV-NRSQKDIDGKKDITAALAA 254

  Fly   529 EEDFFKN----SKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRE------TIEQQADAFKATR- 582
            |..||.:    ..|..|.|.....:|.::.|:..:.|....:..:      :||::.:.:|..|
Human   255 ERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSIEKEVEEYKNFRP 319

  Fly   583 ----------FNLETEWKNNFPRLRESGRDEL--FDKAKGEILDEVVTLS---QISAKKWDDALS 632
                      ..:..::..:|.:..|...|::  ::.:.|..::.:....   ::...::|:
Human   320 DDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPFELVKMEFDE--- 381

  Fly   633 TKLWEKLSNYVFESIYLPAAQSG---SQNSFNTMVDIKLRQWAEQALPAKSVEAGWEALQQEFIS 694
            .:|..::| |..::|:  ..::|   ...:|.|:|..::::..|..|  |.|    :.:..|.||
Human   382 KELRREIS-YAIKNIH--GIRTGLFTPDMAFETIVKKQVKKIREPCL--KCV----DMVISELIS 437

  Fly   695 LMER-SKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDMLRVIQL---NTLEDRFV--HDKQEW 753
            .:.: :||.|.:..:.::::..|......|.....:.:.:|..|:|   ||..:.|:  .:.|:.
Human   438 TVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNHEDFIGFANAQQR 502

  Fly   754 DSAVKFLESSVNAKLV-------QTEETLAQMFGPGQMRRITHWQYLT--------QDQQKRRSV 803
            .:.:...::|.|...:       .|...:..|.|..:    .:|..||        .|::|.:..
Human   503 SNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSK----EYWFVLTAENLSWYKDDEEKEKKY 563

  Fly   804 KNELDKILKND-------TKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFPVYRKHFLQQA 861
            ...:|.:...|       :||:..|.:.|...|.|:.::..:..:|.....:|    :..||:..
Human   564 MLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSW----KASFLRAG 624

  Fly   862 L--QRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVINREARRL-DKEIK 923
            :  :|..|..||... .:.|::..:...|..|..:::.:..:..:.:  .::|:..|.| .|.|.
Human   625 VYPERVGDKEKASET-EENGSDSFMHSMDPQLERQVETIRNLVDSYM--AIVNKTVRDLMPKTIM 686

  Fly   924 AVL----DEFSDDEEKKGYLLTGKRVLLAEELIKVRQIQEKLEEFINSLNQ 970
            .::    .||...|........|.:..|.||..:..|.::::....::|.:
Human   687 HLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKE 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	84/287 (29%)
DNM1	NP_001361198.1	DYNc	6..245	CDD:197491	78/249 (31%)
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	38..45		4/6 (67%)
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	64..66		0/1 (0%)
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	136..139		2/2 (100%)
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	205..208		2/2 (100%)
		Dynamin_M	216..502	CDD:395818	59/299 (20%)
		G5 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	235..238		1/3 (33%)
		PH_dynamin	520..629	CDD:269958	20/116 (17%)
		GED	657..745	CDD:396682	14/83 (17%)
		PHA03247	<747..852	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810