DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and eat-3

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_495986.3	Gene:	eat-3 / 174476	WormBaseID:	WBGene00001134	Length:	964	Species:	Caenorhabditis elegans

Alignment Length:	902	Identity:	470/902 - (52%)
Similarity:	628/902 - (69%)	Gaps:	33/902 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 RGALKLRYIVLGGAIGGGVSLSKKYEEWKDGLPNF---KWLEDAMPQGERWSQFSRNLIEVGSLV 148
            |..|||||.:..|.|||.|:....|||||..||:.   :|.:    ....|::||:.:    ..:
Worm    79 RHLLKLRYFIATGVIGGSVAARTWYEEWKSNLPDLSLPEWFD----SNGSWNEFSQKM----KGI 135

  Fly   149 KNAIEVDPKLKQLGEDKLSEWR---NWFDSRLDD--AIEAADYQGVQIVETKDDLKAKTTVAALG 208
            |:....|      |::|.:||.   ..|..:.:|  ........|...|..|:.:...:.::|..
Worm   136 KDGFGAD------GQNKWAEWMAKFEQFKQQKEDQNGNSGGGGGGEGNVPVKEPVILASLMSAFS 194

  Fly   209 ITSDESRKKYEKL--QSQVETLQTEIMNVQIKYQKELEKMEKENRELRQQYLILKTNKKTTAKKI 271
            ...||..:|.:.:  :.:::.||.|::..|.:||:|||::||||:.|:|:.|:.........|::
Worm   195 SKKDEPEEKKDNVSAEERIQKLQEEMLKTQSQYQRELERLEKENKVLKQRLLLSDDKAAIRLKRL 259

  Fly   272 KKSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRA 336
            |:|||||||||||.|:.||:.|..:|:|||||||||||:|||||||.:|:|||||||||||||||
Worm   260 KRSLIDMYSEVLDLLNEYDSSYNTSDNLPRVVVVGDQSAGKTSVLEMVAQARIFPRGSGEMMTRA 324

  Fly   337 PVKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPG 401
            ||||||:||||||||||||.||:|||||:|||.||.:.|.||:.|||.|||||||||::|||||.
Worm   325 PVKVTLSEGPYHVAQFRDSSREFDLTKETDLQQLRNETEVRMRNSVRDGKTVSNEVISLTVKGPN 389

  Fly   402 LQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQC 466
            |.|||||||||:|||:|.|||.:|||.|.:|:|.:|.|||||||||||||||||||||||||...
Worm   390 LPRMVLVDLPGVISTVTADMARETKDDIIRMSKAHMENPNAIILCIQDGSVDAERSNVTDLVSSI 454

  Fly   467 DPLGRRTIFVLTKVDLAEE-LADPDRIRKILSGKLFPMKALGYYAVVTGRGRKDDSIDAIRQYEE 530
            ||.|:|||.||||||:||: ||:||||:|||.|||||||||||:.||||||...||||.||:|||
Worm   455 DPSGKRTILVLTKVDMAEKNLANPDRIKKILEGKLFPMKALGYFGVVTGRGNSSDSIDEIRKYEE 519

  Fly   531 DFFKNSKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPR 595
            :||..|:|. |.||:.|.|:|:||:||||||.||:|||::||.|.|||:|.:||||.||||:|.|
Worm   520 NFFSTSQLL-RDGVLKPSQMTTRNMSLAVSDCFWRMVRDSIESQTDAFRAAKFNLEAEWKNHFLR 583

  Fly   596 LRESGRDELFDKAKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSF 660
            :|:..||||:|||:||||||:|.||.|..::|:..|..|||..:|::||:.|.:||..|.|..||
Worm   584 IRQLNRDELYDKARGEILDEIVNLSLIGVEEWEKLLQDKLWSGISSHVFDQILMPAYASSSSGSF 648

  Fly   661 NTMVDIKLRQWAEQALPAKSVEAGWEALQQEF---ISLMERSKKAQDHDGIFDQLKSAVVDEAIR 722
            ||.|||||:.:|::.|..||:|.||:.|::.|   |:...|:||  |||.:||.||.||::||:.
Worm   649 NTTVDIKLKHFADKQLAQKSIETGWDTLKEVFFRQINQDARTKK--DHDPVFDALKEAVIEEAML 711

  Fly   723 RHSWEDKAIDMLRVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRI 787
            .|.|:|||:|.|||||||.:|||.|.||:.||:|..||..:.:.:|...::.|....|||...:.
Worm   712 THGWDDKAMDYLRVIQLNAMEDRAVQDKRSWDAACNFLHKAASERLAAVKKQLTDDRGPGWASKW 776

  Fly   788 THWQYLTQDQQKRRSVKNELDKILKNDTKHLPTLTHDELTTVRKNLQRDNV-DVDTDYIRQTWFP 851
            ..|:..|.|......:::||..||..|.:|...||.|::|.:|:|::...| :|.|:.||:.|..
Worm   777 LMWKTPTADNHYSCVIQDELYSILGADPEHKQALTDDDITVIRRNIETKGVLEVPTESIRKQWKL 841

  Fly   852 VYRKHFLQQALQRAKDCRKAYYLYTQQGAE-CEISCSDVVLFWRIQQVIKITGNALRQQVINREA 915
            |::||||::.:..:|||...|.:|.|...| .:|.|..:|||:|||:::.:|.||||||:.|.|.
Worm   842 VFKKHFLERIINSSKDCLSMYQMYRQGMIEGQDIDCQTIVLFYRIQKMVNLTCNALRQQITNTEH 906

  Fly   916 RRLDKEIKAVLDEFSDDEEKKGYLLTGKRVLLAEELIKVRQIQEKLEEFINSLNQEK 972
            |||:||||.|||::|.:.:.|...|||:||.||||:.:||:||||||||:..|.:||
Worm   907 RRLEKEIKEVLDDWSQEPDIKKKYLTGRRVDLAEEIQQVRRIQEKLEEFMAQLQREK 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	205/274 (75%)
eat-3	NP_495986.3	Smc	<186..>278	CDD:224117	34/91 (37%)
eat-3	NP_495986.3	DLP_1	286..560	CDD:206738	205/274 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156322
Domainoid	1	1.000	493	1.000	Domainoid score	I179
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14618
Inparanoid	1	1.050	886	1.000	Inparanoid score	I200
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52400
OrthoDB	1	1.010	-	-		D202097at33208
OrthoFinder	1	1.000	-	-		FOG0006841
OrthoInspector	1	1.000	-	-		oto19052
orthoMCL	1	0.900	-	-		OOG6_105511
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3740
SonicParanoid	1	1.000	-	-		X4932
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800