DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and fzo-1

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	NP_495161.1	Gene:	fzo-1 / 173990	WormBaseID:	WBGene00001509	Length:	774	Species:	Caenorhabditis elegans

Alignment Length:	467	Identity:	101/467 - (21%)
Similarity:	179/467 - (38%)	Gaps:	119/467 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   269 KKIKKSLIDMYSEVLD---ELSGY----------------------DTGYTMADHLPR----VVV 304
            ::.||.|.|:|.|:.|   ||.|.                      |:..|:.|...|    ||.
Worm    41 REAKKVLGDVYGELKDNVAELEGVYKDIKENDFVSSEQREEIEAIGDSIKTIMDTFQRDNMKVVF 105

  Fly   305 VGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTLAEGPYHVAQFRDSDREYDL-------- 361
            .|..|:||::.:.::...::.|:|.|. .|...::|..:||.....|..|:.::.|:
Worm   106 FGRTSNGKSTTINAMLHEKVLPQGMGH-TTCCFLQVEGSEGEVGHLQLDDNPQKIDMKMLGKIGH 169

  Fly   362 ---TKESDLQDLRRD---VEFRMKASVRGG-KTVSNEVIAMTVKGPGLQRMVLVDLPGIISTMTV 419
               .:.|||..:.:|   ..|..|.|..|. :.:.|:|             |::|.||:..:...
Worm   170 ALSDENSDLPAMGQDSLLKVFHPKKSESGECRLLQNDV-------------VILDSPGVDLSPEF 221

  Fly   420 D--------------MASDTKDSIHQMTKHY-------MSNPNAIILCIQDGSVDAERSNVTDLV 463
            |              :.|:.:.::.|..|::       :|.||..||..:..:..||..|:.|:.
Worm   222 DSWIDKHCLDADVFVLVSNAESTLTQAEKNFFLRVAKKLSKPNVFILNNRWDASAAETENIEDVK 286

  Fly   464 MQCDPLGRRTIFVLTKVDLAEELADPDRI-----RKILSGKLFPMKALG-----YYAVVTGRGRK 518
            .|  .|.|...|::.::::..|....|||     |::|..:|   ||.|     |.|  .|.|.:
Worm   287 KQ--HLTRFRQFLVDELEVCSEREVNDRIFFVSSREVLESRL---KARGLVQKAYQA--EGHGTR 344

  Fly   519 DDSIDAIRQYEEDFFKNSKLF-----HRRGVIMPHQVTSRN-------LSLAVSDRFWKMVRETI 571
            ........::.|.....|.:.     |.|   ..|::..:.       |:.|...|  ..::..:
Worm   345 ALEFQNFERHFEHCISRSAIHTKFEAHNR---RAHEMIGKMRLNLNSVLTSAAEQR--SKLQNNL 404

  Fly   572 EQQADAFKATRFNLETEWKNNFPRLRESGRDELFDKAKGEILDEVVTLSQI---SAKKWDDALS- 632
            .:....|...|.|. |:::..:....|..|.|:..|...:..:|:..|..|   ..:.:|.:.|
Worm   405 NESTRTFNECRVNF-TQFEKAYREQTEQLRAEVHLKVSADFFEEIARLDAIIDRFEQPFDGSSSG 468

  Fly   633 -TKLWEKLSNYV 643
             ||..|.|:.:|
Worm   469 MTKYKEDLAIFV 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	70/335 (21%)
fzo-1	NP_495161.1	DLP_2	101..359	CDD:206739	62/278 (22%)
fzo-1	NP_495161.1	Fzo_mitofusin	609..767	CDD:282633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900