DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and Dnm3

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_017454151.1	Gene:	Dnm3 / 171574	RGDID:	727949	Length:	873	Species:	Rattus norvegicus

Alignment Length:	656	Identity:	156/656 - (23%)
Similarity:	264/656 - (40%)	Gaps:	119/656 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||.:.:.:.|..|.  .|.:....||::.|||.||:||:||||:.......||||| ::||.|
  Rat     7 EELIPLVNRLQDAFSA--LGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-IVTRRP 68

  Fly   338 VKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGL 402
            :.:.|.......|:|.....:    |.:|..::|.::|..........|.:|:..|.:.|..|.:
  Rat    69 LVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRHEIEAETDRVTGMNKGISSVPINLRVYSPHV 129

  Fly   403 QRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCD 467
            ..:.|:|||||......|...|.:..|..|...:::..|.:||.:...:.|...|:...|..:.|
  Rat   130 LNLTLIDLPGITKVPVGDQPPDIEYQIRDMIMQFITRENCLILAVTPANTDLANSDALKLAKEVD 194

  Fly   468 PLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD----DSIDAIRQY 528
            |.|.|||.|:||:||.:|..|   .|.:|..||.|::. ||..|| .|.:||    ..|.|....
  Rat   195 PQGLRTIGVITKLDLMDEGTD---ARDVLENKLLPLRR-GYVGVV-NRSQKDIDGKKDIKAAMLA 254

  Fly   529 EEDFFKNSKLFH----RRGVIMPHQVTSRNLSLAVSDRFWKMVRET--------------IEQQA 575
            |..||.:...:.    |.|.  ||      |...::.:....:|:|              ||.:.
  Rat   255 ERKFFLSHPAYRHIADRMGT--PH------LQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEV 311

  Fly   576 DAFK------ATR-----FNLETEWKNNFPRLRESGRD-----ELFDKAK-GEILDEVVTLSQIS 623
            :|||      .||     ..:..::..:|.:..|...|     ||...|| ..|..|......:.
  Rat   312 EAFKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVK 376

  Fly   624 AKKWDDALSTKLWEKLSNYVFESIYLPAAQSG---SQNSFNTMVDIKLRQWAEQALPAKSVEAGW 685
            .:..:..|..::     :|..::|:  ..::|   ...:|..:|..::.:....:|  |||
  Rat   377 MEFNEKELRREI-----SYAIKNIH--GIRTGLFTPDMAFEAIVKKQIVKLKGPSL--KSV---- 428

  Fly   686 EALQQEFISLMER-SKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDM------LRVIQLNTLE 743
            :.:.||.|:.::: :|:..:...:.::.:..|.:....|   |.|..|.      ::|..:||..
  Rat   429 DLVMQELINTVKKCTKRLANFPRLCEETERIVANHIRER---EGKTKDQVLLLIDIQVSYINTNH 490

  Fly   744 DRF------------VHDKQEWDSAVKFLESS---VNAKLVQTEETLAQMFGPGQMRRITHWQYL 793
            :.|            ||.|....:....|..|   |..|...|...:..|.|..:    .:|..|
  Rat   491 EDFIGFANAQQRSSQVHKKSTIGNQGTNLPPSRQIVIRKGWLTVSNIGIMKGGSK----GYWFVL 551

  Fly   794 T--------QDQQKRRSVKNELDKILKND-------TKHLPTLTHDELTTVRKNLQRDNVDVDTD 843
            |        .|::|.:.....||.:...|       :||:..|.:.|...|.|:.:...:..|:.
  Rat   552 TAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKGFMSSKHVFALFNTEQRNVYKDYRSLELACDSQ 616

  Fly   844 YIRQTW 849
            ....:|
  Rat   617 EDVDSW 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	86/295 (29%)
Dnm3	XP_017454151.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810