DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and Opa1

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_006248559.1	Gene:	Opa1 / 171116	RGDID:	708423	Length:	1015	Species:	Rattus norvegicus

Alignment Length:	956	Identity:	505/956 - (52%)
Similarity:	664/956 - (69%)	Gaps:	67/956 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 QMPPPSRGY----GMLVVRILRGALKLRYIVLGGAIGGGVSLSKKYEEWKDGLP---NFKW---- 123
            ::.|...||    .....|:....||||||:||.|:|||.:..|.::||||.:|   ::||
  Rat    74 KLSPTKYGYQPRRNFWPARLAARLLKLRYIILGSAVGGGYTAKKTFDEWKDMIPDLSDYKWIVPD 138

  Fly   124 -------------LEDAMPQGERWSQFSRNLIEVG---SLVKNAIEVDPKLKQLGEDKLSEWRNW 172
                         :..|:|..|..:.|:.:|.::.   ||:|:.....|||       :||....
  Rat   139 FIWEIDEYIDLEKIRKALPSSEDLANFAPDLDKIAESLSLLKDFFTAGPKL-------VSEVIEA 196

  Fly   173 FDSRL------DDAIEAADY---------QGV---------QIVETKDDLKAKTTVAALGITSDE 213
            .:..|      :.|..|.|:         :|:         ||.|.:::.:   ..|....||..
  Rat   197 SEPLLLLGTPGETAFRATDHGSESDKHYRKGLLGELILLQQQIQEHEEEAR---RAAGQYSTSYA 258

  Fly   214 SRKKYEKLQSQVETLQTEIMNVQIKYQKELEKMEKENRELRQQYLIL-KTNKKTTAKKIKKSLID 277
            .:|:....:.:::.||.|:::.|:|||:.||::||||:|||:  |:| |.:|....:|:||||||
  Rat   259 QQKRKVSDKEKIDQLQEELLHTQLKYQRILERLEKENKELRK--LVLQKDDKGIHHRKLKKSLID 321

  Fly   278 MYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTL 342
            |||||||.||.||..|...|||||||||||||:|||||||.||:||||||||||||||:||||||
  Rat   322 MYSEVLDVLSDYDASYNTQDHLPRVVVVGDQSAGKTSVLEMIAQARIFPRGSGEMMTRSPVKVTL 386

  Fly   343 AEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGLQRMVL 407
            :|||:|||.|:||.||:|||||.||..||.::|.||:.:|:.|.|||.|.|::.|||||||||||
  Rat   387 SEGPHHVALFKDSSREFDLTKEEDLAALRHEIELRMRKNVKEGCTVSPETISLNVKGPGLQRMVL 451

  Fly   408 VDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRR 472
            |||||:|:|:|..||.|||::|..::|.||.|||||||||||||||||||.|||||.|.||.|||
  Rat   452 VDLPGVINTVTSGMAPDTKETIFSISKAYMQNPNAIILCIQDGSVDAERSIVTDLVSQMDPHGRR 516

  Fly   473 TIFVLTKVDLAEE-LADPDRIRKILSGKLFPMKALGYYAVVTGRGRKDDSIDAIRQYEEDFFKNS 536
            ||||||||||||: :|.|.||::|:.|||||||||||:|||||:|...:||:|||:|||:||:||
  Rat   517 TIFVLTKVDLAEKNVASPSRIQQIIEGKLFPMKALGYFAVVTGKGNSSESIEAIREYEEEFFQNS 581

  Fly   537 KLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGR 601
            ||. :..::..||||:|||||||||.|||||||::|||||:|||||||||||||||:|||||..|
  Rat   582 KLL-KTSMLKAHQVTTRNLSLAVSDCFWKMVRESVEQQADSFKATRFNLETEWKNNYPRLRELDR 645

  Fly   602 DELFDKAKGEILDEVVTLSQISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSGSQNSFNTMVDI 666
            :|||:|||.||||||::|||::.|.|::.|...|||::|.:|.|:|||||||:.:..:|||.|||
  Rat   646 NELFEKAKNEILDEVISLSQVTPKHWEEILQQSLWERVSTHVIENIYLPAAQTMNSGTFNTTVDI 710

  Fly   667 KLRQWAEQALPAKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAI 731
            ||:||.::.||.|:||..||.||.||...| ...|.::||.|||:||.||.:|:|:||.|.|.|.
  Rat   711 KLKQWTDKQLPNKAVEVAWETLQDEFSRFM-TEPKGKEHDDIFDKLKEAVKEESIKRHKWNDFAE 774

  Fly   732 DMLRVIQLNTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLTQD 796
            |.|||||.|.||||.:.|||:||:|:.|:|.::..:|..||..:..|.||...:|..:|:..||:
  Rat   775 DSLRVIQHNALEDRSISDKQQWDAAIYFMEEALQGRLKDTENAIENMIGPDWKKRWIYWKNRTQE 839

  Fly   797 QQKRRSVKNELDKILKNDTKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFPVYRKHFLQQA 861
            |......||||:|:||.:.:|...|..||:|||||||:...|:||...|:.||..|||:|||:.|
  Rat   840 QCVHNETKNELEKMLKVNDEHPAYLASDEITTVRKNLESRGVEVDPSLIKDTWHQVYRRHFLKTA 904

  Fly   862 LQRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVINREARRLDKEIKAVL 926
            |.....||:.:|.|.:...:.|:.|:|||||||||:::.||.|.||||:.|.|.|||:|.:|.||
  Rat   905 LNHCNLCRRGFYYYQRHFIDSELECNDVVLFWRIQRMLAITANTLRQQLTNTEVRRLEKNVKEVL 969

  Fly   927 DEFSDDEEKKGYLLTGKRVLLAEELIKVRQIQEKLEEFINSLNQEK 972
            ::|::|.|||..|||||||.|||:|.|||:|||||:.||.:|:|||
  Rat   970 EDFAEDGEKKVKLLTGKRVQLAEDLKKVREIQEKLDAFIEALHQEK 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	197/274 (72%)
Opa1	XP_006248559.1	DLP_1	342..616	CDD:206738	193/274 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334867
Domainoid	1	1.000	569	1.000	Domainoid score	I220
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H14618
Inparanoid	1	1.050	940	1.000	Inparanoid score	I329
OMA	1	1.010	-	-		QHG52400
OrthoDB	1	1.010	-	-		D202097at33208
OrthoFinder	1	1.000	-	-		FOG0006841
OrthoInspector	1	1.000	-	-		oto96000
orthoMCL	1	0.900	-	-		OOG6_105511
Panther	1	1.100	-	-	LDO	PTHR11566
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4932
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910