DRSC/TRiP Functional Genomics Resources

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Protein Alignment Opa1 and Mfn2

DIOPT Version :9

Sequence 1:NP_725369.1 Gene:Opa1 / 36578 FlyBaseID:FBgn0261276 Length:972 Species:Drosophila melanogaster
Sequence 2:NP_001272849.1 Gene:Mfn2 / 170731 MGIID:2442230 Length:757 Species:Mus musculus


Alignment Length:850 Identity:160/850 - (18%)
Similarity:308/850 - (36%) Gaps:264/850 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   258 LILKTNKKTTAKKIKKSLIDMYSE--------------VLDELSGY---------DT-------- 291
            |..:.|...|.||.|:.:.::.:.              :.::|..|         ||        
Mouse     4 LFSRCNSIVTVKKDKRHMAEVNASPLKHFVTAKKKINGIFEQLGAYIQESASFLEDTHRNTELDP 68

  Fly   292 -----------GY---------TMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRA 336
                       ||         .:|....:|...|..|:||::|:.::...::.|.|.|. .|..
Mouse    69 VTTEEQVLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGH-TTNC 132

  Fly   337 PVKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVE-----FRMKASVRGGKTVSNEVIAMT 396
            .::|...:|  |.|        :.||:.|:.:...:.|.     ......:..|..||  |:...
Mouse   133 FLRVGGTDG--HEA--------FLLTEGSEEKKSVKTVNQLAHALHQDEQLHAGSMVS--VMWPN 185

  Fly   397 VKGPGLQ-RMVLVDLPGIISTMTVD--------------MASDTKDSIHQMTKHY-------MSN 439
            .|.|.|: .:||:|.|||..|..:|              :.::::.::.|..|.:       :|.
Mouse   186 SKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKQFFHKVSERLSR 250

  Fly   440 PNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRI-----RKILSGK 499
            ||..||..:..:..:|...:.::..|  .:.|.|.|::.::.:.:.....|||     :::||.:
Mouse   251 PNIFILNNRWDASASEPEYMEEVRRQ--HMERCTSFLVDELGVVDRAQAGDRIFFVSAKEVLSAR 313

  Fly   500 LFPMKALGYYAVVTGRGRKDDSIDAIRQYEEDFFKNSKLFHR-----------RGVIMPHQVTSR 553
            :  .||.|   :..|.|...:... :|.:|   |:|   |.|           :.....|.|.::
Mouse   314 V--QKAQG---MPEGGGALAEGFQ-VRMFE---FQN---FERQFEECISQSAVKTKFEQHTVRAK 366

  Fly   554 NLSLAVSDRFWKMVRETIEQQADAFKATRFNLETEWKNNFPRLRESGRDEL-FDKAKGEIL--DE 615
            .::.||     :::.:::...|...:.  :.||         :||..:|.| |...:.|:|  |.
Mouse   367 QIAEAV-----RLIMDSLHIAAQEQRV--YCLE---------MREERQDRLRFIDKQLELLAQDY 415

  Fly   616 VVTLSQISAKKWDDALSTKLWEKL-------SNYVFESIYLPAAQSGSQNSFNTMVDIKL-RQWA 672
            .:.:.||: ::.:..:||.:.|::       ..|..:....|......:|..:..::..| |..:
Mouse   416 KLRIKQIT-EEVERQVSTAMAEEIRRLSVLVDEYQMDFHPSPVVLKVYKNELHRHIEEGLGRNLS 479

  Fly   673 EQALPAKSVEAGWEALQQEFISLMERSKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDMLRVI 737
            ::.  :.::.:..:.:||:.|            ||:...|..::.::           ||||...
Mouse   480 DRC--STAIASSLQTMQQDMI------------DGLKPLLPVSMRNQ-----------IDMLVPR 519

  Fly   738 QLNTLE-----DRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLTQDQ 797
            |..:|.     |:...|.||   .::|..|.....||.      :..||...||    ..|....
Mouse   520 QCFSLSYDLNCDKLCADFQE---DIEFHFSLGWTMLVN------RFLGPKNSRR----ALLGYSD 571

  Fly   798 QKRRSVKNELDKILKNDTKHLP-----TLTHDEL-----TTVRKNLQRDNVDVDT---------- 842
            |.:|.:.      |......:|     :||.:||     |.:.....|.::.:..          
Mouse   572 QVQRPLP------LTPANPSMPPLPQSSLTQEELMVSMVTGLASLTSRTSMGILVVGGVVWKAVG 630

  Fly   843 ---------------DYIRQTWFP-----VYRKHFLQQALQRAKDCRKAYYLYTQQGAECEISCS 887
                           .|.|.||..     .:::.|::.|.:      |...:.:..|:.|.    
Mouse   631 WRLIALSFGLYGLLYVYERLTWTTKAKERAFKRQFVEYASE------KLQLIISYTGSNCS---- 685

  Fly   888 DVVLFWRIQQVIKITGNALRQQV------INREARRLDKEIKAVLDEFSDDEEKKGYLLTGKRVL 946
                 .::||.:..|...|.|||      :.:|...::|:::|:     |..:.:..||..|...
Mouse   686 -----HQVQQELSGTFAHLCQQVDITRDNLEQEIAAMNKKVEAL-----DSLQSRAKLLRNKAGW 740

  Fly   947 LAEEL 951
            |..||
Mouse   741 LDSEL 745

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Opa1NP_725369.1 DLP_1 298..572 CDD:206738 65/316 (21%)
Mfn2NP_001272849.1 Part of a helix bundle domain, formed by helices from N-terminal and C-terminal regions. /evidence=ECO:0000250|UniProtKB:Q8IWA4 30..94 6/63 (10%)
DLP_2 97..349 CDD:206739 61/278 (22%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 103..110 3/6 (50%)