DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and Dnm1

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_006497725.1	Gene:	Dnm1 / 13429	MGIID:	107384	Length:	914	Species:	Mus musculus

Alignment Length:	713	Identity:	148/713 - (20%)
Similarity:	298/713 - (41%)	Gaps:	101/713 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 PRGSGEMMTRAPVKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSN 390
            ||||| ::||.|:.:.|.......|:|.....:    |.:|.:::|.::|..........|.:|.
Mouse   104 PRGSG-IVTRRPLVLQLVNSTTEYAEFLHCKGK----KFTDFEEVRLEIEAETDRVTGTNKGISP 163

  Fly   391 EVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAE 455
            ..|.:.|..|.:..:.||||||:......|...|.:..|..|...:::..|.:||.:...:.|..
Mouse   164 VPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLA 228

  Fly   456 RSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD- 519
            .|:...:..:.||.|:|||.|:||:||.:|..|   .|.:|..||.|::. ||..|| .|.:||
Mouse   229 NSDALKIAKEVDPQGQRTIGVITKLDLMDEGTD---ARDVLENKLLPLRR-GYIGVV-NRSQKDI 288

  Fly   520 ---DSIDAIRQYEEDFFKN----SKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRE------TI 571
               ..|.|....|..||.:    ..|..|.|.....:|.::.|:..:.|....:..:      :|
Mouse   289 DGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSI 353

  Fly   572 EQQADAFKATR-----------FNLETEWKNNFPRLRESGRDEL--FDKAKGEILDEVVTLS--- 620
            |::.|.:|..|           ..:..::..:|.:..|...|::  ::.:.|..::.:....
Mouse   354 EKEVDEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPF 418

  Fly   621 QISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSG---SQNSFNTMVDIKLRQWAEQALPAKSVE 682
            ::...::|:   .:|..::| |..::|:  ..::|   ...:|...|..::::..|.::  |.|
Mouse   419 ELVKMEFDE---KELRREIS-YAIKNIH--GIRTGLFTPDLAFEATVKKQVQKLKEPSI--KCV- 474

  Fly   683 AGWEALQQEFISLMER-SKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDMLRVIQL---NTLE 743
               :.:..|..|.:.: |:|.|.:..:.::::..|......|.....:.:.:|..|:|   ||..
Mouse   475 ---DMVVSELTSTIRKCSEKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNH 536

  Fly   744 DRFV--HDKQEWDSAVKFLESSVNAKLV-------QTEETLAQMFGPGQMRRITHWQYLT----- 794
            :.|:  .:.|:..:.:...::|.|...:       .|...:..|.|..:    .:|..||
Mouse   537 EDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSK----EYWFVLTAENLS 597

  Fly   795 ---QDQQKRRSVKNELDKILKND-------TKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTW 849
               .|::|.:.....:|.:...|       :||:..|.:.|...|.|:.::..:..:|.....:|
Mouse   598 WYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSW 662

  Fly   850 FPVYRKHFLQQAL--QRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVIN 912
                :..||:..:  :|..|..||... .:.|::..:...|..|..:::.:..:..:.:  .::|
Mouse   663 ----KASFLRAGVYPERVGDKEKASET-EENGSDSFMHSMDPQLERQVETIRNLVDSYM--AIVN 720

  Fly   913 REARRL-DKEIKAVL----DEFSDDEEKKGYLLTGKRVLLAEELIKVRQIQEKLEEFINSLNQ 970
            :..|.| .|.|..::    .||...|........|.:..|.||..:..|.::::....::|.:
Mouse   721 KTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKE 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	71/259 (27%)
Dnm1	XP_006497725.1	DLP_1	100..340	CDD:206738	71/245 (29%)
		Dynamin_M	262..548	CDD:366427	57/299 (19%)
		PH_dynamin	566..675	CDD:269958	20/116 (17%)
		GED	702..791	CDD:366984	14/84 (17%)
		PHA03247	<793..910	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810