Protein Alignment Opa1 and Dnm1

DIOPT Version :10

• Sequence 1: NP_725369.1
• Gene: Opa1 / 36578
• FlyBaseID: FBgn0261276
• Length: 972
• Species: Drosophila melanogaster
• Sequence 2: XP_006497725.1
• Gene: Dnm1 / 13429
• MGIID: 107384
• Length: 914
• Species: Mus musculus
• Alignment Length: 713
• Identity: 148/713 - (20%)
• Similarity: 298/713 - (41%)
• Gaps: 101/713 - (14%)

  Fly   326 PRGSGEMMTRAPVKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSN 390
            ||||| ::||.|:.:.|.......|:|.....:    |.:|.:::|.::|..........|.:|.
Mouse   104 PRGSG-IVTRRPLVLQLVNSTTEYAEFLHCKGK----KFTDFEEVRLEIEAETDRVTGTNKGISP 163

  Fly   391 EVIAMTVKGPGLQRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAE 455
            ..|.:.|..|.:..:.||||||:......|...|.:..|..|...:::..|.:||.:...:.|..
Mouse   164 VPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSDLA 228

  Fly   456 RSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD- 519
            .|:...:..:.||.|:|||.|:||:||.:|..|   .|.:|..||.|::. ||..|| .|.:||
Mouse   229 NSDALKIAKEVDPQGQRTIGVITKLDLMDEGTD---ARDVLENKLLPLRR-GYIGVV-NRSQKDI 288

  Fly   520 ---DSIDAIRQYEEDFFKN----SKLFHRRGVIMPHQVTSRNLSLAVSDRFWKMVRE------TI 571
               ..|.|....|..||.:    ..|..|.|.....:|.::.|:..:.|....:..:      :|
Mouse   289 DGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLLSI 353

  Fly   572 EQQADAFKATR-----------FNLETEWKNNFPRLRESGRDEL--FDKAKGEILDEVVTLS--- 620
            |::.|.:|..|           ..:..::..:|.:..|...|::  ::.:.|..::.:....
Mouse   354 EKEVDEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGARINRIFHERFPF 418

  Fly   621 QISAKKWDDALSTKLWEKLSNYVFESIYLPAAQSG---SQNSFNTMVDIKLRQWAEQALPAKSVE 682
            ::...::|:   .:|..::| |..::|:  ..::|   ...:|...|..::::..|.::  |.|
Mouse   419 ELVKMEFDE---KELRREIS-YAIKNIH--GIRTGLFTPDLAFEATVKKQVQKLKEPSI--KCV- 474

  Fly   683 AGWEALQQEFISLMER-SKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDMLRVIQL---NTLE 743
               :.:..|..|.:.: |:|.|.:..:.::::..|......|.....:.:.:|..|:|   ||..
Mouse   475 ---DMVVSELTSTIRKCSEKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLIDIELAYMNTNH 536

  Fly   744 DRFV--HDKQEWDSAVKFLESSVNAKLV-------QTEETLAQMFGPGQMRRITHWQYLT----- 794
            :.|:  .:.|:..:.:...::|.|...:       .|...:..|.|..:    .:|..||
Mouse   537 EDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSK----EYWFVLTAENLS 597

  Fly   795 ---QDQQKRRSVKNELDKILKND-------TKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTW 849
               .|::|.:.....:|.:...|       :||:..|.:.|...|.|:.::..:..:|.....:|
Mouse   598 WYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDYRQLELACETQEEVDSW 662

  Fly   850 FPVYRKHFLQQAL--QRAKDCRKAYYLYTQQGAECEISCSDVVLFWRIQQVIKITGNALRQQVIN 912
                :..||:..:  :|..|..||... .:.|::..:...|..|..:::.:..:..:.:  .::|
Mouse   663 ----KASFLRAGVYPERVGDKEKASET-EENGSDSFMHSMDPQLERQVETIRNLVDSYM--AIVN 720

  Fly   913 REARRL-DKEIKAVL----DEFSDDEEKKGYLLTGKRVLLAEELIKVRQIQEKLEEFINSLNQ 970
            :..|.| .|.|..::    .||...|........|.:..|.||..:..|.::::....::|.:
Mouse   721 KTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAEQAQRRDEMLRMYHALKE 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	71/259 (27%)
		OPA1_C	629..972	CDD:466080	67/380 (18%)
Dnm1	XP_006497725.1	DLP_1	100..340	CDD:206738	71/245 (29%)
		Dynamin_M	261..548	CDD:460033	58/303 (19%)
		PH_dynamin	566..675	CDD:269958	20/116 (17%)
		GED	701..791	CDD:460495	15/85 (18%)
		PHA03247	<793..910	CDD:223021