DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Opa1 and Dnm3

DIOPT Version :9

Sequence 1:	NP_725369.1	Gene:	Opa1 / 36578	FlyBaseID:	FBgn0261276	Length:	972	Species:	Drosophila melanogaster
Sequence 2:	XP_006496664.1	Gene:	Dnm3 / 103967	MGIID:	1341299	Length:	873	Species:	Mus musculus

Alignment Length:	812	Identity:	179/812 - (22%)
Similarity:	313/812 - (38%)	Gaps:	183/812 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 KSLIDMYSEVLDELSGYDTGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAP 337
            :.||.:.:.:.|..|.  .|.:....||::.|||.||:||:||||:.......||||| ::||.|
Mouse     7 EELIPLVNRLQDAFSA--LGQSCLLELPQIAVVGGQSAGKSSVLENFVGRDFLPRGSG-IVTRRP 68

  Fly   338 VKVTLAEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAMTVKGPGL 402
            :.:.|.......|:|.....:    |.:|..::|.::|..........|.:|:..|.:.|..|.:
Mouse    69 LVLQLVTSKAEYAEFLHCKGK----KFTDFDEVRHEIEAETDRVTGMNKGISSIPINLRVYSPHV 129

  Fly   403 QRMVLVDLPGIISTMTVDMASDTKDSIHQMTKHYMSNPNAIILCIQDGSVDAERSNVTDLVMQCD 467
            ..:.|:|||||......|...|.:..|..|...:::..|.:||.:...:.|...|:...|..:.|
Mouse   130 LNLTLIDLPGITKVPVGDQPPDIEYQIRDMIMQFITRENCLILAVTPANTDLANSDALKLAKEVD 194

  Fly   468 PLGRRTIFVLTKVDLAEELADPDRIRKILSGKLFPMKALGYYAVVTGRGRKD----DSIDAIRQY 528
            |.|.|||.|:||:||.:|..|   .|.:|..||.|::. ||..|| .|.:||    ..|.|....
Mouse   195 PQGLRTIGVITKLDLMDEGTD---ARDVLENKLLPLRR-GYVGVV-NRSQKDIDGKKDIKAAMLA 254

  Fly   529 EEDFFKNSKLFH----RRGVIMPHQVTSRNLSLAVSDRFWKMVRET--------------IEQQA 575
            |..||.:...:.    |.|.  ||      |...::.:....:|:|              ||.:.
Mouse   255 ERKFFLSHPAYRHIADRMGT--PH------LQKVLNQQLTNHIRDTLPNFRNKLQGQLLSIEHEV 311

  Fly   576 DAFK------ATR-----FNLETEWKNNFPRLRESGRD-----ELFDKAK-GEILDEVVTLSQIS 623
            :|||      .||     ..:..::..:|.:..|...|     ||...|| ..|..|......:.
Mouse   312 EAFKNFKPEDPTRKTKALLQMVQQFAVDFEKRIEGSGDQVDTLELSGGAKINRIFHERFPFEIVK 376

  Fly   624 AKKWDDALSTKLWEKLSNYVFESIYLPAAQSG---SQNSFNTMVD---IKLRQWAEQALPA-KSV 681
            .:..:..|..::     :|..::|:  ..::|   ...:|..:|.   :||:.      |: |||
Mouse   377 MEFNEKELRREI-----SYAIKNIH--GIRTGLFTPDMAFEAIVKKQIVKLKG------PSLKSV 428

  Fly   682 EAGWEALQQEFISLMER-SKKAQDHDGIFDQLKSAVVDEAIRRHSWEDKAIDM------LRVIQL 739
                :.:.||.|:.::: :|:..:...:.::.:..|.:....|   |.|..|.      ::|..:
Mouse   429 ----DLVMQELINTVKKCTKRLANFPRLCEETERIVANHIRER---EGKTKDQVLLLIDIQVSYI 486

  Fly   740 NTLEDRF------------VHDKQEWDSAVKFLESS---VNAKLVQTEETLAQMFGPGQMRRITH 789
            ||..:.|            ||.|....:....|..|   |..|...|...:..|.|..:    .:
Mouse   487 NTNHEDFIGFANAQQRSSQVHKKSTIGNQGTNLPPSRQIVIRKGWLTVSNIGIMKGGSK----GY 547

  Fly   790 WQYLT--------QDQQKRRSVKNELDKILKND-------TKHLPTLTHDELTTVRKNLQRDNVD 839
            |..||        .|::|.:.....||.:...|       :||:..|    ..|.::|:.:|
Mouse   548 WFVLTAESLSWYKDDEEKEKKYMLPLDNLKVRDVEKGFMSSKHVFAL----FNTEQRNVYKD--- 605

  Fly   840 VDTDYIRQTWFPVYRKHFLQQALQRAKD--------CRKAYY---------LYTQQGAECEISCS 887
                         ||  ||:.|....:|        .|...|         ....:..:.|....
Mouse   606 -------------YR--FLELACDSQEDVDSWKASLLRAGVYPDKSVGSNKTENDENGQAENFSM 655

  Fly   888 DVVLFWRIQQV-------IKITGNALRQQV--------INREARRLDKEIKAVLDEFSDDEEKKG 937
            |..|..:::.:       :.|....:|..:        ||.....::.|:.|.|  :|.:::...
Mouse   656 DPQLERQVETIRNLVDSYMSIINKCIRDLIPKTIMHLMINNVKDFINSELLAQL--YSSEDQNTL 718

  Fly   938 YLLTGKRVLLAEELIKVRQIQEKLEEFINSLN 969
            ...:.::....:|::::.|..::....|..:|
Mouse   719 MEESAEQAQRRDEMLRMYQALKEALAIIGDIN 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Opa1	NP_725369.1	DLP_1	298..572	CDD:206738	86/295 (29%)
Dnm3	XP_006496664.1	DYNc	6..245	CDD:197491	79/249 (32%)
		Dynamin_M	216..502	CDD:366427	65/315 (21%)
		PH_dynamin	526..635	CDD:269958	27/134 (20%)
		GED	660..749	CDD:366984	11/90 (12%)
		MISS	<757..845	CDD:318115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0699
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810