DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8468 and ESBP6

DIOPT Version :9

Sequence 1:	NP_610940.1	Gene:	CG8468 / 36577	FlyBaseID:	FBgn0033913	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_014274.1	Gene:	ESBP6 / 855598	SGDID:	S000005069	Length:	673	Species:	Saccharomyces cerevisiae

Alignment Length:	359	Identity:	85/359 - (23%)
Similarity:	138/359 - (38%)	Gaps:	90/359 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SQDELASKGLVSKQPE--NIKE--ENEGEEEIEEAAVVVPPDSGWAWVVMVASFLCCTVIDGIVF 68
            |..:|.::|:...:|:  .:|:  .|:...::|     :|||.|:.|||....||......|
Yeast   172 SGKDLEAQGITEFEPDEPTVKKVFTNKSTGQLE-----LPPDGGYGWVVTFCVFLTMFSTWG--- 228

  Fly    69 CSGLIQEQLMAEFGVSKAYV----------AFVSSLLSGCYLMAG----PFVSAMANRFGFRPVT 119
            |:        |.|||..||.          .:..:|::|..:..|    |.|.|:....|.|...
Yeast   229 CN--------ASFGVDLAYYLNHDTYPGASKYDYALIAGLTVFLGQLLSPLVMALMRIIGLRTTM 285

  Fly   120 ITGAIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGS 184
            :.|.......:.|:.|.|.:..|::..|.:.|....::::||..::..:|.|.||:|.||::.|:
Yeast   286 LFGDAVMLAAYLLASFTTKLWQLYVTQGFMVGCSISLIFVPATTVLPGWFLKKRAVAMGVSLLGT 350

  Fly   185 GVGTFVFAPLTKILLK--SGWRYTLAIQGIIVLSCALFGLAFRPIQPITLSVTNEEGDEQEKKKL 247
            |.|..|:...|..:|.  ...|:.|.|.||   ||::..|       :.:::..|..
Yeast   351 GAGGVVYGLATNKMLSDFGNTRWCLRIIGI---SCSISVL-------VAIALLKERN-------- 397

  Fly   248 NGHGNTVAPTPQLH-----------QAAF-----TKPLPE--------GRFAYSMPNSAHNTY-- 286
                    |||.:.           :|.|     |||...        ..|||:|.....::|
Yeast   398 --------PTPAIGLKSPRAMFEQLKAMFSLKVITKPFVVLIALWFMFALFAYNMMVFTLSSYAI 454

  Fly   287 -MGASQRNHYPTAQEIFKGMNLERRPSGTAQGSK 319
             .|.|..: ..|...|..|.....||.....|.|
Yeast   455 SKGLSSHD-ASTLTAILNGSQSIGRPLMGLAGDK 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8468	NP_610940.1	MFS	50..>227	CDD:119392	51/192 (27%)
CG8468	NP_610940.1	MFS	<481..658	CDD:119392
ESBP6	NP_014274.1	MFS_MCT_SLC16	212..606	CDD:340910	74/314 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I1250
Isobase	1	0.950	-	0.891027	Normalized mean entropy	S3509
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
TreeFam	0	0.000	Not matched by this tool.
	7	6.910