DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8468 and MCH5

DIOPT Version :9

Sequence 1:	NP_610940.1	Gene:	CG8468 / 36577	FlyBaseID:	FBgn0033913	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_014951.4	Gene:	MCH5 / 854483	SGDID:	S000005833	Length:	521	Species:	Saccharomyces cerevisiae

Alignment Length:	291	Identity:	73/291 - (25%)
Similarity:	103/291 - (35%)	Gaps:	108/291 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TKSQDELASKGL-VSKQP---ENIK------EENEGEEEIEEAAVVVPPDSGW-AWVVMVASFLC 59
            ||.:   .:||. :..||   ||..      :|.:..||||..     |:.|: ||||....||
Yeast    60 TKKE---VNKGTDIESQPHWGENTSSTHDSDKEEDSNEEIESF-----PEGGFKAWVVTFGCFL- 115

  Fly    60 CTVIDGIVFCSGL----------IQEQLMAEFGVSK--------AYVAFVSSLLSGCYLMAGPFV 106
                 |::.|.||          :|:..::...||.        .:|...|.::||.|.
Yeast   116 -----GLIACFGLLNSTGVIESHLQDNQLSSESVSTIGWLFSLFLFVCSASCIISGTYF------ 169

  Fly   107 SAMANRFGFRPVTITGAIFAAICFGLSYFATSVEY--LFLIYGVLGGIGFCMVYIPAVVIIGFYF 169
                :|.|||.:.|.|.:|...  ||...|.|.:|  ..|.:.::.|.|..:|..|.|.:...||
Yeast   170 ----DRNGFRTIMIVGTVFHVA--GLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYF 228

  Fly   170 EKWRALATGVAMCGSGVGTFVF----------------------------------APLTKILLK 200
            .|.|..|..:|..|..||..||                                  ..|:.||:|
Yeast   229 FKRRGTALAMATIGGSVGGVVFPIMLRSFFSMKSDTDPTYGFVWGIRTLGFLDLALLTLSIILVK 293

  Fly   201 --------------SGWRYTLAIQGIIVLSC 217
                          |.|||.|.   :.:|.|
Yeast   294 ERLPHVIENSKDGESRWRYILR---VYILQC 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8468	NP_610940.1	MFS	50..>227	CDD:119392	57/236 (24%)
CG8468	NP_610940.1	MFS	<481..658	CDD:119392
MCH5	NP_014951.4	MFS_MCT_SLC16	106..510	CDD:340910	58/237 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343225
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.840