DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8468 and CG14196

DIOPT Version :9

Sequence 1:	NP_610940.1	Gene:	CG8468 / 36577	FlyBaseID:	FBgn0033913	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_573367.1	Gene:	CG14196 / 32915	FlyBaseID:	FBgn0031002	Length:	600	Species:	Drosophila melanogaster

Alignment Length:	642	Identity:	131/642 - (20%)
Similarity:	222/642 - (34%)	Gaps:	175/642 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 VPPDSGWAWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFV---SSLLSGCY-LMA 102
            |.||:||||:|.||:.:....|...:...|.:..:.:::.|:|.:.:..:   :..:|.|. |:.
  Fly    35 VAPDAGWAWIVCVAAGVSNLSIYPCLQQFGFLFRERLSDLGMSSSQITAIINANPAVSACTGLLN 99

  Fly   103 GPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGF 167
            ||    |..||.||.|.:.|::..:....|:.|..:.....:.|.:|.|.|..:....:.:.|..
  Fly   100 GP----MFRRFTFRQVAMAGSLLISGSLILTAFCETFLSYMVAYALLFGFGMGISVSASSLAINT 160

  Fly   168 YFEKWRALATGVAMCGSGVGTFVFAP--LTKILLKSGWRYTLAIQGIIVLSCALFGLAFRPIQ-- 228
            ||:|.|..|.|.:...:|:|. :|.|  :|.:|...|.:.|..:...|.|...:..|.::|::
  Fly   161 YFQKKRRRAAGFSWTITGLGP-IFLPHLVTFLLTIYGVQGTTLLFAAISLHSFVCALIYQPVRYH 224

  Fly   229 ---PITLSVTNEEGDE--------QEKKKLNG---------------HGNTVAP--TPQLHQA-- 263
               |:......|:..|        |:|::..|               .|..:..  ||.|.:|
  Fly   225 VKPPVEQLADQEQQAEALCAHCSWQQKREPGGIFSSQYLCQDDDAQRPGYEICEPGTPMLSRAND 289

  Fly   264 ---AFTKPLPEGRFAYSMPNSAHNTYMGASQRNHYPTAQEIFKGMNLERRPSGTAQGSKGTELKQ 325
               .....|..||..:...:|:.:  :..:||.|.|.::|               |..:..|.
  Fly   290 GWYGSRLSLTSGRLRFRTISSSKD--LEQTQRLHCPISEE---------------QNHESDEF-- 335

  Fly   326 LRKSQPTTPNGDPQQLTFNLHKELTTVGENEEEAENDNLLETEAKPVTIQARRHTVSGRRPQDIG 390
            ||.:     |...:::..||..:|......:.|..|:|..|.||:               .::.|
  Fly   336 LRPN-----NFRRERVESNLEAKLCCQCSAKREEHNNNRKEKEAE---------------AEEAG 380

  Fly   391 KRSAAAAHEAHHGQSHSSSRPMYRDDIFFSGSLTRIPQYQSQTSLAYHMSVTRLPTKQDMLEDRQ 455
            ..||                |::...:.|...:.
  Fly   381 MESA----------------PLHDPQMSFLAKVV------------------------------- 398

  Fly   456 KGCRICPEAVRRTLSTMLDTTLLKSPAFMCLAFSGFLTMMGF-------FVPFTFLVDRAKAAGM 513
                           |..|..||:...|:.|...  ||::.|       ..|| .|||    .|.
  Fly   399 ---------------TFFDLDLLRDFTFVNLVAG--LTIINFGELNFSILTPF-ILVD----FGF 441

  Fly   514 DE---QAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNNFALTAGGIATICSGIVINTATQW 575
            |.   ..|..:|:|:.:...|       :..|...|..|.|......|.:.......|:.....:
  Fly   442 DTPQITLAMSLLAGLDITMRF-------MVPFLTEKIPWDNRVFFLIGVVGIALGRTVVACTRSY 499

  Fly   576 TFAL----FFGICIACFSALRSLIAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAG 628
            :..|    :.|:|....:....||....:.|.:|..|.|..:|..||....|.|..|
  Fly   500 SLILCSFVWIGLCKGVRTIFWPLIIPGYVPLNRLPGASGLQLLISGLFTLIGGPFVG 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8468	NP_610940.1	MFS	50..>227	CDD:119392	44/182 (24%)
CG8468	NP_610940.1	MFS	<481..658	CDD:119392	37/162 (23%)
CG14196	NP_573367.1	MFS	71..>221	CDD:119392	38/154 (25%)
CG14196	NP_573367.1	MFS	<410..579	CDD:119392	37/161 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.891027	Normalized mean entropy	S3509
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
	7	6.800