DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8468 and Slc16a1

DIOPT Version :9

Sequence 1:	NP_610940.1	Gene:	CG8468 / 36577	FlyBaseID:	FBgn0033913	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_033222.1	Gene:	Slc16a1 / 20501	MGIID:	106013	Length:	493	Species:	Mus musculus

Alignment Length:	617	Identity:	126/617 - (20%)
Similarity:	207/617 - (33%)	Gaps:	210/617 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PPDSGWAWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSKAYVAFVSSLLSGCYLMAGPFVS 107
            |||.||.|.|:|.:|:.............:..:::...|..:.:.|:::||::.......||..|
Mouse    13 PPDGGWGWAVLVGAFISIGFSYAFPKSITVFFKEIEVIFSATTSEVSWISSIMLAVMYAGGPISS 77

  Fly   108 AMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYGVLGGIGFCMVYIPAVVIIGFYFEKW 172
            .:.|::|.|||.|.|...:......:.|..:|:.|:|..||:||:|......||:.:||.||.|.
Mouse    78 ILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYLCIGVIGGLGLAFNLNPALTMIGKYFYKK 142

  Fly   173 RALATGVAMCGSGVGTFVFAPLTKILLK-SGWRYTLAIQGIIVLSCALFGLAFRPIQPITLSVTN 236
            |.||.|:||.||.|.....|||.:.... ..||.:..|.|.::|:|.:.|...|||
Mouse   143 RPLANGLAMAGSPVFLSTLAPLNQAFFDIFDWRGSFLILGGLLLNCCVAGSLMRPI--------- 198

  Fly   237 EEGDEQEKKKLNGHGNTVAPTPQLHQAAFTKPLPEGRFAYSMPNSAHNTYMGASQRNHYPTAQEI 301
              |.||.|
Mouse   199 --GPEQVK--------------------------------------------------------- 204

  Fly   302 FKGMNLERRPSGTAQGSKGTELKQLRKSQPTTPNGDPQQLTFNLHKELTTVGENEEEAENDNLLE 366
                                 |::|:..:..
Mouse   205 ---------------------LEKLKSKESL---------------------------------- 214

  Fly   367 TEAKPVTIQARRHTVSGRRPQDIGKRSAAAAHEAHHGQSHSSSRPMYRDDIFFSGSLTRIPQYQS 431
                                |:.||..|
Mouse   215 --------------------QEAGKSDA------------------------------------- 222

  Fly   432 QTSLAYHMSVTRLPTKQDMLEDRQKGCRICPEAVRRTLSTMLDTTLLKSPAFMCLAFSGFLTM-M 495
                           ..|::....||.::   :|.:|::..||.:|.....|: |..||.:.| .
Mouse   223 ---------------NTDLIGGSPKGEKL---SVFQTINKFLDLSLFTHRGFL-LYLSGNVVMFF 268

  Fly   496 GFFVPFTFLVDRAKAAGMDEQAAYGVLSGIGVVNTFARIVCGSLSSFPAVKPLWLNNFA--LTAG 558
            |.|.|..||....|:.....:.:..:||.:..|:..||...|..::...::|.....||  :.|.
Mouse   269 GLFTPLVFLSSYGKSKDFSSEKSAFLLSILAFVDMVARPSMGLAANTKWIRPRIQYFFAASVVAN 333

  Fly   559 GIATICSGIVINTATQWTFALFFGICIACFSALRSLI---AVELIGLEKLTNAYGFLMLFQGLAA 620
            |   :|..:...:.|...|.::.|:....|..|.|::   .::|||.::.::|.|.:.:.:....
Mouse   334 G---VCHLLAPLSTTYVGFCVYAGVFGFAFGWLSSVLFETLMDLIGPQRFSSAVGLVTIVECCPV 395

  Fly   621 TFGSPIAGGLYVMTGSYNAAFYFAGGLILLSA 652
            ..|.|:.|.|..|.|.|... |:|.|:||:.|
Mouse   396 LLGPPLLGRLNDMYGDYKYT-YWACGVILIIA 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8468	NP_610940.1	MFS	50..>227	CDD:119392	54/177 (31%)
CG8468	NP_610940.1	MFS	<481..658	CDD:119392	47/178 (26%)
Slc16a1	NP_033222.1	2A0113	1..466	CDD:273325	126/617 (20%)
		MFS	20..432	CDD:119392	121/610 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..493
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835593
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D916876at2759
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11360
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850