DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8468 and gem-1

DIOPT Version :9

Sequence 1:	NP_610940.1	Gene:	CG8468 / 36577	FlyBaseID:	FBgn0033913	Length:	678	Species:	Drosophila melanogaster
Sequence 2:	NP_001379120.1	Gene:	gem-1 / 181458	WormBaseID:	WBGene00008214	Length:	771	Species:	Caenorhabditis elegans

Alignment Length:	726	Identity:	151/726 - (20%)
Similarity:	279/726 - (38%)	Gaps:	128/726 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PENIKEENEGEEEIEEAAV-VVPPDSGWAWVVMVASFLCCTVIDGIVFCSGLIQEQLMAEFGVSK 85
            |.:.:.::...|.:|.... .|..|.|:.|:|::||||...|.||..||.|::..::...|...:
Worm    44 PVSARSDDSDAESVESLTERPVYKDGGYGWLVVLASFLMHAVCDGASFCFGIVFVKIQEHFQCGR 108

  Fly    86 AYVAFVSSLLSGCYLMAGPFVSAMANRFGFRPVTITGAIFAAICFGLSYFATSVEYLFLIYGVLG 150
            ......:|:.....|:..|....:::..|.|...|.||....:...::.|.:.:.:..:.:|:..
Worm   109 FVSMITASMFLSLPLIMSPVAGIVSDILGCRMSIIIGASICTVSCIIAMFCSHIFFFMISFGLGC 173

  Fly   151 GIGFCMVYIPAVVIIGFYFEKWRALATGVAMCGSGVGTFVFAPLTKILLKSGWRYTLAIQGIIVL 215
            |:|...:|..|:||:.:||||.|.|||..|:.|:||||.::    .|||.....|..:....|.:
Worm   174 GVGMSFIYNAAIVIVTYYFEKRRGLATSFAVSGTGVGTVIY----PILLNLSMIYLASFVSDIRI 234

  Fly   216 SCALFGLAFRPIQPITLSVTNEE--------------------GDEQEKKKLNGHGNTVAPTPQL 260
            ....|.:.:..|..|...:.:.|                    .||:|        |...||.
Worm   235 ILIFFAVMYFVIAVIGFFIKDVEWESDKTDFKLRKFQKYIAKMDDEKE--------NNTNPTD-- 289

  Fly   261 HQAAFTKPLPEGRFAYSMPN-SAHNTYMG----------ASQRNHYPTAQE---IFKG------- 304
               ||.      |.|.|:|| :..|.:.|          |.:::..||..:   :|..
Worm   290 ---AFM------RHAISLPNLNILNNHSGSIQSICDAAKAERKSDKPTRSKSVALFDNKHQMSSI 345

  Fly   305 -----------------MNLERRPSGTAQGSKGTELKQLRKSQPTTPNGDPQQLTFNLHKELTTV 352
                             :.|...|..|.:..:...:.::..|.......:.:....||.:..|..
Worm   346 PEYSMLNTNLANLEHLDLELANSPCTTVRAQRRRVISKVSMSVDQINELEDEAFHINLFQSSTES 410

  Fly   353 GENEEEAENDNLLETEAKPVTIQARRHTVSGRRPQDIGKRSAAAAHEAHHGQSHSSSRPMYRDDI 417
            ..::|.:.:|:.:..:....:.:.....:.....:.|.|.....|..|  ..|..:|..|.|:.:
Worm   411 ESDDESSSDDSEMSNDGDSSSSELSEKNLDEPTTKLINKNLENVAFRA--TSSVPNSARMNRNSV 473

  Fly   418 ------FFSGSLTRIPQYQSQ--TSLAYHMSVTRLPTKQDMLEDRQKGCRICPEAVRRTLSTMLD 474
                  .|.|.:......||:  |:|   :::.::|: ..||..|:....:..:.::......|:
Worm   474 AAGTSNMFGGRVIASNAIQSRHATNL---IAMGKIPS-APMLVARKNRKSMIGKPIQGFYKKWLE 534

  Fly   475 T------TLLKSPAFMCLAFSGFLTMMGFFVPFT----FLVDRAKAAGMDEQAAYGVLSGIGVVN 529
            |      .::...|::.||.|.........||:.    :.:|..|   |:|..|..:...||:.|
Worm   535 TEKPIYQEVIHCRAYIYLALSVLCLYFILDVPYVCFYEYSIDTLK---MEESEANYIYYSIGISN 596

  Fly   530 TFARIVCGSLSSFPAVKPLWLNNFALTAGGIATICSGIVINTATQWT-------FALFFGICIAC 587
            ..:.::.|:|:.       |......|....:.:..||.|..:|:..       ..:.||:.|..
Worm   597 FISVLLFGTLAD-------WTRKHITTIYASSMVGVGITIMFSTRINSLVELVIVGVCFGVTITS 654

  Fly   588 FSALRSL---IAVELIGLEKLTNAYGFLMLFQGLAATFGSPIAGGLYVMTGSYNAAFYFAGGLIL 649
            ...|:|:   |..|.:.|.::  ||..:.:.:|:|:..|.||...:...||.|...|:.:|...|
Worm   655 NYVLQSILVTICFEDVNLFQV--AYSLIAMIEGVASLIGPPIFALVREATGGYTVVFFISGIFAL 717

  Fly   650 LSAFLCYPLTW 660
            .|.|..:..::
Worm   718 ASGFFGFMFSY 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8468	NP_610940.1	MFS	50..>227	CDD:119392	49/176 (28%)
CG8468	NP_610940.1	MFS	<481..658	CDD:119392	45/190 (24%)
gem-1	NP_001379120.1	MFS	72..>254	CDD:421695	51/185 (28%)
gem-1	NP_001379120.1	MFS	<543..727	CDD:421695	45/195 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D352338at33208
OrthoFinder	1	1.000	-	-		FOG0000033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X70
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820