Protein Alignment Sox15 and TCF7L1

DIOPT Version :9

• Sequence 1: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: XP_006712172.1
• Gene: TCF7L1 / 83439
• HGNCID: 11640
• Length: 589
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 105/515 - (20%)
• Similarity: 172/515 - (33%)
• Gaps: 174/515 - (33%)

  Fly     3 PSYDH--------EHPHHL-----LTNYNSKKY----PHVSRTPEYSHST-GSDYPEHGGYLTD- 48
            ||..|        :||||:     |..|::..:    |....:||....| |...|.|...|:.
Human   170 PSPAHLSNKVPVVQHPHHMHPLTPLITYSNDHFSPGSPPTHLSPEIDPKTAGIPRPPHPSELSPY 234

  Fly    49 --------GRLMHE-----SNSDAGIYHVRQGS-EHSSPSLHSPAIQSSGYENEHLNEAVLAAHS 99
                    |::.|.     ......:|.:..|. .|..|:|...|..||          ::::..
Human   235 YPLSPGAVGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMNASMSS----------LVSSRF 289

  Fly   100 HSHSPMPMVSSAYVGGGTASGSLINSNIPLLGGGGNSVLNKFLSHPHAGMVGGGTGQMEDCTSHS 164
            ..|    ||:.|:.|            :|..|            .||..:|             |
Human   290 SPH----MVAPAHPG------------LPTSG------------IPHPAIV-------------S 313

  Fly   165 PIEAASMWSYDYKGDLCAPNCGYLERHKPLPADLK-----YRPGGTQSKSAKESRIRRPMNAFMV 224
            ||                      .:.:|.|..|.     ..|...:.:..|:..:::|:||||:
Human   314 PI----------------------VKQEPAPPSLSPAVSVKSPVTVKKEEEKKPHVKKPLNAFML 356

  Fly   225 WAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHP------NYK 283
            :.|..|.|:..|.....:|.::::||:||.:|:.:::..|.|.|.:.|.:|...:|      ||.
Human   357 YMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHSQLYPTWSARDNYG 421

  Fly   284 YRPRRRKQSKLRAMQPGGKEQSESSPNPGTGGSKSNPKLATPPLATASSSYTTPTDESTCNSTNQ 348
            .:.:|:::.:|...|    .|.:.....|...|||.....         .|..|  |..|:|...
Human   422 KKKKRKREKQLSQTQ----SQQQVQEAEGALASKSKKPCV---------QYLPP--EKPCDSPAS 471

  Fly   349 NHGQ-----STPGGLYEQPLKPTYSPSSVDCYSNADSTEQIESLAANCPPALLNESSPTGGGYDN 408
            :||.     :||......|..|.           |..:||.:.|:..
Human   472 SHGSMLDSPATPSAALASPAAPA-----------ATHSEQAQPLSLT------------------ 507

  Fly   409 SLLLKKLTKPSPSRAAKSRQEKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSVAVVAA 468
                   |||. :||..:.......|.:....|..|..||..:.:...||.....|::|:
Human   508 -------TKPE-TRAQLALHSAAFLSAKAAASSSGQMGSQPPLLSRPLPLGSMPTALLAS 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	23/76 (30%)
TCF7L1	XP_006712172.1	CTNNB1_binding	30..251	CDD:285538	19/80 (24%)
		SOX-TCF_HMG-box	346..417	CDD:238684	21/70 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910