DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sox15 and TCF7L2

DIOPT Version :9

Sequence 1:NP_523739.2 Gene:Sox15 / 36575 FlyBaseID:FBgn0005613 Length:784 Species:Drosophila melanogaster
Sequence 2:NP_001354872.1 Gene:TCF7L2 / 6934 HGNCID:11641 Length:619 Species:Homo sapiens


Alignment Length:600 Identity:131/600 - (21%)
Similarity:209/600 - (34%) Gaps:193/600 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 HHLLTNYNSKKYPHV---------------SRTPEYSHSTGS-----DYPEHGGYLTDGRLMHES 55
            |.:...|...|:|.:               :|:|..:|...:     .:|.|...||.  |:..|
Human   145 HQIAVQYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTP--LITYS 207

  Fly    56 NSDAGIYHVRQGSEHSSPSLHSPAIQSSGYENEHLNEAVLAAHSHSHSPMPMVSSAY--VGGGTA 118
            |            ||.:|....|          ||...|.........|.|...|.|  :..||.
Human   208 N------------EHFTPGNPPP----------HLPADVDPKTGIPRPPHPPDISPYYPLSPGTV 250

  Fly   119 S------GSLINSN----IPLLGGG----------GNSVLNKFLSH-------------PHAGMV 150
            .      |.|:...    .|:..||          .|:.:::|..|             ||..:|
Human   251 GQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIV 315

  Fly   151 GGGTGQMEDCTSHSPIEAASMWSYDYKGDLCAPNCGYLERHKPLPADLKYRPGGTQSKSAKESRI 215
               |..::..:|.|.:           |.|          |.....|.|      :.:..|:..|
Human   316 ---TPTVKQESSQSDV-----------GSL----------HSSKHQDSK------KEEEKKKPHI 350

  Fly   216 RRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHP 280
            ::|:||||::.|..|.|:..|.....:|.::::||::|.:|:.:::..|.|.|.:.|.:||..:|
Human   351 KKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYP 415

  Fly   281 NYKYRPR-RRKQSKLRAMQPGGKEQSESSPNPGTGGSKSNPKLATPPLATASSSYTTPTDESTCN 344
            .:..|.. .:|:.:.|..|||  |.:|.|.      ...||.|:.||:...|:       ...|.
Human   416 GWSARDNYGKKKKRKRDKQPG--ETNEHSE------CFLNPCLSLPPITDLSA-------PKKCR 465

  Fly   345 S---TNQNHGQSTPGGLYEQPLKPTYSPSSVDCYSNADSTEQIESLAANCPPALLNESSPTGGGY 406
            :   .:|.:....|....::.::  |......|.|               ||:           .
Human   466 ARFGLDQQNNWCGPCRRKKKCVR--YIQGEGSCLS---------------PPS-----------S 502

  Fly   407 DNSLLLKKLTKP----SPSRAAKSRQEKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSVAVVA 467
            |.|||......|    ||.|.|||:.|:          :|....|.:....|...:.|...|::.
Human   503 DGSLLDSPPPSPNLLGSPPRDAKSQTEQ----------TQPLSLSLKPDPLAHLSMMPPPPALLL 557

  Fly   468 ARGMY---VTCNNRGLLDHGHSVKGTFYPPVSVSEDDNSTSM-RNSISALQQHCNVVTSTPSSSG 528
            |...:   ..|.| |.||         .||.::.....|:|: :.|.|:|..|        ||..
Human   558 AEATHKASALCPN-GALD---------LPPAALQPAAPSSSIAQPSTSSLHSH--------SSLA 604

  Fly   529 GTMPTSEMSSYTVSM 543
            ||.| ..:|..|.|:
Human   605 GTQP-QPLSLVTKSL 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox15NP_523739.2 SOX-TCF_HMG-box 214..285 CDD:238684 22/70 (31%)
TCF7L2NP_001354872.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..96
CTNNB1-binding. /evidence=ECO:0000250 1..53
CTNNB1_binding 17..259 CDD:400583 27/137 (20%)
Mediates interaction with MAD2L2. /evidence=ECO:0000269|PubMed:19443654 201..395 52/247 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 318..350 8/58 (14%)
SOX-TCF_HMG-box 353..420 CDD:238684 21/66 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 420..441 7/22 (32%)
Nuclear localization signal. /evidence=ECO:0000255 425..430 1/4 (25%)
Promoter-specific activation domain 459..505 10/80 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..547 19/86 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..619 17/62 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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