Protein Alignment Sox15 and SOX12

DIOPT Version :10

• Sequence 1: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_008874.2
• Gene: SOX12 / 6666
• HGNCID: 11198
• Length: 315
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 84/281 - (29%)
• Similarity: 137/281 - (48%)
• Gaps: 45/281 - (16%)

  Fly   193 PLPADLKYR-PGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSL 256
            |.||:...| ||..::.|   ..|:|||||||||::.||:|:.|:.||:|||::||.||::|:.|
Human    20 PGPAEEGAREPGWCKTPS---GHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLL 81

  Fly   257 TPQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRKQ---SKLRAMQPGGK---EQSESSPN-PGTG 314
            ...::.|:|.||||||:.||.::|:||||||::.:   :|.|...|||.   .:.:..|. ||.|
Human    82 QDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGSGGGSRLKPGPQLPGRG 146

  Fly   315 GSKSNPKLATPPLATASSSYTTPTDESTCNSTNQNHGQSTPGGLYEQPLKPTYS--PSSVDCYSN 377
            |.::    |..||...:::   |.|:.     ..:..:.....|.|.|.:..:.  |:.......
Human   147 GRRA----AGGPLGGGAAA---PEDDD-----EDDDEELLEVRLVETPGRELWRMVPAGRAARGQ 199

  Fly   378 ADSTEQIESLAANCPPALLNESSPTGGGYDNSLLLKKLTKPSPSRAAKSRQEKLAKSEEKNKGSQ 442
            |:..:......|....|    :|||               ||.....:..:|:.|.:||..:.:.
Human   200 AERAQGPSGEGAAAAAA----ASPT---------------PSEDEEPEEEEEEAAAAEEGEEETV 245

  Fly   443 SQGQSQQGIYAATYPLAPTSV 463
            :.|:...| :.:..|..|..:
Human   246 ASGEESLG-FLSRLPPGPAGL 265

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	HMG-box_SoxF	214..289	CDD:438841	42/74 (57%)
		PHA03273	305..>391	CDD:223031	16/88 (18%)
SOX12	NP_008874.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..40		7/22 (32%)
		HMG-box_SF	29..116	CDD:469606	45/89 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	100..288		44/198 (22%)
		Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000250|UniProtKB:Q04890	283..315