Protein Alignment Sox15 and SOX9

DIOPT Version :10

• Sequence 1: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_000337.1
• Gene: SOX9 / 6662
• HGNCID: 11204
• Length: 509
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 144/542 - (26%)
• Similarity: 202/542 - (37%)
• Gaps: 145/542 - (26%)

  Fly   101 SHSPMPMVSSAYVGGGTASGSLINSNIPLLGGGGNSVLNKFLSHPHAGMVGGGTGQM--EDCTSH 163
            |.:|.|.:|....|....|||            |:...|   :.|.......|...:  |.....
Human    19 SGAPSPTMSEDSAGSPCPSGS------------GSDTEN---TRPQENTFPKGEPDLKKESEEDK 68

  Fly   164 SPI---EAASMWSYDYKGDLCAPNCGYLERHKPLPADLKYRPGGTQSKSAKESRIRRPMNAFMVW 225
            .|:   ||.|.....|...|.           |:|.    |..|:   |..:..::|||||||||
Human    69 FPVCIREAVSQVLKGYDWTLV-----------PMPV----RVNGS---SKNKPHVKRPMNAFMVW 115

  Fly   226 AKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRK 290
            |:..|:||||:.|.||||:|||.|||.||.|...::||:|||||||||.|..:||:|||:|||||
Human   116 AQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRK 180

  Fly   291 QSKL-RAMQPGGKEQSESSPN----------------------PG--TGGSKSNPKLATPPLATA 330
            ..|. :|......||:..|||                      ||  :|.|:..|   |||
Human   181 SVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPP---TPP---- 238

  Fly   331 SSSYTTP-TDESTCNSTNQNHGQSTPGGLYEQPL---KPTYSPSSVDCYSNA---DSTEQIESLA 388
                ||| ||.....:..:..|:..|.|..:.|:   .......|.|..||.   |..|..:.|.
Human   239 ----TTPKTDVQPGKADLKREGRPLPEGGRQPPIDFRDVDIGELSSDVISNIETFDVNEFDQYLP 299

  Fly   389 ANCPPAL--------------LNESSPTGGGYDNSLLLKKLTKPSPSR---------------AA 424
            .|..|.:              ::.::.|.....:..:.|:...|.|.:               .|
Human   300 PNGHPGVPATHGQVTYTGSYGISSTAATPASAGHVWMSKQQAPPPPPQQPPQAPPAPQAPPQPQA 364

  Fly   425 KSRQEKLAKSEEKNKG-----SQSQGQSQQGIYAATYPLAPTSVAVVAARGMYVTCNNRGLLDHG 484
            ...|:..|..::....     |...||||: .:..|..|:|:..:............:...|.|
Human   365 APPQQPAAPPQQPQAHTLTTLSSEPGQSQR-THIKTEQLSPSHYSEQQQHSPQQIAYSPFNLPH- 427

  Fly   485 HSVKGTFYPPVSVSEDDNSTSMRNSISALQQHCNVVTSTPSSSGGTMPTSEMSSYTVSMADNCGN 549
               ....|||::.|:.| .|..:||            |:..|......|...|::|.
Human   428 ---YSPSYPPITRSQYD-YTDHQNS------------SSYYSHAAGQGTGLYSTFTY-------- 468

  Fly   550 LRLSMNELSGNEYLPSANAYGM 571
                ||......|.|.|:..|:
Human   469 ----MNPAQRPMYTPIADTSGV 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	HMG-box_SoxF	214..289	CDD:438841	48/74 (65%)
		PHA03273	305..>391	CDD:223031	27/116 (23%)
SOX9	NP_000337.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..67		13/62 (21%)
		Sox_N	22..94	CDD:463586	20/101 (20%)
		Dimerization (DIM). /evidence=ECO:0000305|PubMed:31194875	63..103		12/57 (21%)
		PQA. /evidence=ECO:0000305|PubMed:31194875	63..103		12/57 (21%)
		HMG-box_SoxE	104..178	CDD:438840	47/73 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..273		39/123 (32%)
		Transactivation domain (TAM). /evidence=ECO:0000269|PubMed:31194875	224..307		26/93 (28%)
		9aaTAD 1. /evidence=ECO:0000269|PubMed:31194875	275..284		2/8 (25%)
		9aaTAD 2. /evidence=ECO:0000269|PubMed:31194875	290..298		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	330..415		14/85 (16%)
		Transactivation domain (TAC). /evidence=ECO:0000269|PubMed:8640233	394..509		24/123 (20%)
		9aaTAD 3. /evidence=ECO:0000269|PubMed:34342803	460..468		2/7 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	479..509		3/8 (38%)