Protein Alignment Sox15 and SOX17

DIOPT Version :9

• Sequence 1: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_071899.1
• Gene: SOX17 / 64321
• HGNCID: 18122
• Length: 414
• Species: Homo sapiens
• Alignment Length: 528
• Identity: 147/528 - (27%)
• Similarity: 189/528 - (35%)
• Gaps: 173/528 - (32%)

  Fly   142 LSHPHAGMVGGGTGQMEDCTSHSPIEAASMWSYDYKGDLCAPNCGYLERHKPLPADLKYR----- 201
            :|.|.||.......|.:   |..|...|.:          .| |.:.|...|: .|:|.:
Human     1 MSSPDAGYASDDQSQTQ---SALPAVMAGL----------GP-CPWAESLSPI-GDMKVKGEAPA 50

  Fly   202 ----PGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRR 262
                |.|...::..||||||||||||||||.|||:||.:|||||||:|||||||.|::||..::|
Human    51 NSGAPAGAAGRAKGESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKR 115

  Fly   263 PYVEEAERLRVIHMTEHPNYKYRPRRRKQSKLRAMQPGGKEQSESSPN----------------- 310
            |:|||||||||.||.:|||||||||||||.|......||.....:.|.
Human   116 PFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRLKRVEGGFLHGLAEPQAAALGPEGGRVAMDGLG 180

  Fly   311 ----------------PGTGGS-KSNPKLATPPLATASSSYTTPT-DESTCNSTNQN---HGQST 354
                            |..||. :....|..|||    ..|..|| |.|..:..:.:   .....
Human   181 LQFPEQGFPAGPPLLPPHMGGHYRDCQSLGAPPL----DGYPLPTPDTSPLDGVDPDPAFFAAPM 241

  Fly   355 PGGLYEQPLKPTYSPSSVDCYSNADSTEQIESLAANCPPALLNESSPTGGGYDNSLLLKKLTKPS 419
            ||   :.|...|||.:.|..|:.              ||      .|..|             |.
Human   242 PG---DCPAAGTYSYAQVSDYAG--------------PP------EPPAG-------------PM 270

  Fly   420 PSRAAKSRQEKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSVAVV--AARGMYVTCNNRGLL- 481
            ..|.                |.:..|.|..|:      |||.|...|  .|.|.......||..
Human   271 HPRL----------------GPEPAGPSIPGL------LAPPSALHVYYGAMGSPGAGGGRGFQM 313

  Fly   482 --DHGHSVKGTFYP--PVSVSEDDNSTSMRNSISALQQHCNVVTSTPSSSGGTMPTSEMSSYTVS 542
              .|.|..:...:|  |...|....:...|:...         .|.|:...|.:..:|...|.
Human   314 QPQHQHQHQHQHHPPGPGQPSPPPEALPCRDGTD---------PSQPAELLGEVDRTEFEQYL-- 367

  Fly   543 MADNCGNLRLSMNELSGNEYLPSANAYGMQYEDFLRYQSND----MDYSTSAVEHKETTSDSASG 603
                                     .:..:.|..|.||.:|    :..|..|:  ....||::|.
Human   368 -------------------------HFVCKPEMGLPYQGHDSGVNLPDSHGAI--SSVVSDASSA 405

  Fly   604 QKCLKYPD 611
            .....|||
Human   406 VYYCNYPD 413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	54/70 (77%)
SOX17	NP_071899.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..66		5/30 (17%)
		SOX-TCF_HMG-box	67..138	CDD:238684	54/70 (77%)
		Sox_C_TAD	201..412	CDD:288887	58/310 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	256..286		11/78 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	305..352		9/55 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5958
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm40697
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.030