DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox15 and sox9a

DIOPT Version :9

Sequence 1:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_571718.1	Gene:	sox9a / 60641	ZFINID:	ZDB-GENE-001103-1	Length:	462	Species:	Danio rerio

Alignment Length:	486	Identity:	142/486 - (29%)
Similarity:	216/486 - (44%)	Gaps:	106/486 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 SHSPMPMVSSAYVGG--GTASGSLINSNIPLLGGGGNSVLNKFLSHPHAGMVGGGTGQMEDCTSH 163
            |.:|.|.:|....|.  .:||||...:..|    ..||:|      ...|.:|......||   .
Zfish    19 SDAPSPSMSEDSAGSPCPSASGSDTENTRP----AENSLL------AADGTLGDFKKDEED---K 70

  Fly   164 SPI---EAASMWSYDYKGDLCAPNCGYLERHKPLPADLKYRPGGTQSKSAKESRIRRPMNAFMVW 225
            .|:   ||.|.....|...|.           |:|.    |..|:   |..:..::|||||||||
Zfish    71 FPVCIREAVSQVLKGYDWTLV-----------PMPV----RVNGS---SKNKPHVKRPMNAFMVW 117

  Fly   226 AKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRK 290
            |:..|:||||:.|.||||:|||.|||.||.|...::||:|||||||||.|..:||:|||:|||||
Zfish   118 AQAARRKLADQYPHLHNAELSKTLGKLWRLLNEVEKRPFVEEAERLRVQHKKDHPDYKYQPRRRK 182

  Fly   291 QSKL-RAMQPGGKEQSESSPNPGTGGSKSNPKLATPPLATASSSYTTPTDESTCNSTNQNHGQST 354
            ..|. ::....|.||:..|||   ...|:..:..:|  |::.....:|::.|     .|:.|..|
Zfish   183 SVKNGQSESEDGSEQTHISPN---AIFKALQQADSP--ASSMGEVHSPSEHS-----GQSQGPPT 237

  Fly   355 PGGLYEQPLKP---------------TYSPSSVDCYSNAD----STEQIESLAAN-----CPPAL 395
            |....:...:|               |..|.|:: :.:.|    |::.||:...|     .||.
Zfish   238 PPTTPKTDTQPGKADLKREARPLQENTGRPLSIN-FQDVDIGELSSDVIETFDVNEFDQYLPPN- 300

  Fly   396 LNESSPTGGGY--------DNSLLLKKLTKPSPSRAAKSRQEKLAKSEEKNKGSQSQGQSQQGIY 452
            .::::|..|||        :.|....:||..:|:...:.|...: |:|:.   |.|....|||
Zfish   301 GHQNAPYAGGYAAWMTKPQNGSPQSSQLTPLNPAEPDQPRTTHI-KTEQL---SPSHYNEQQG-- 359

  Fly   453 AATYPLAPTSVAVVAARGMYVTCNNRGLLDHGHSVKGTFYPPVSVSEDDNSTSMRNSISALQQHC 517
                  :|..::       |.:.|.:.|..:     .|.:|.::.::.|.|.|.:...|:...|.
Zfish   360 ------SPQHIS-------YGSFNVQHLQHY-----STSFPSITRAQYDYSDSHQGGASSYYTHA 406

  Fly   518 NVVTSTPSSSGGTMPTSEMSSYTVSMADNCG 548
            ...:|...|:...|.:|:...|| .:||:.|
Zfish   407 GGQSSGLYSTFSYMSSSQRPMYT-PIADSTG 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	45/70 (64%)
sox9a	NP_571718.1	Sox_N	22..96	CDD:289229	24/101 (24%)
sox9a	NP_571718.1	SOX-TCF_HMG-box	106..176	CDD:238684	44/69 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810