Protein Alignment Sox15 and sox17b

DIOPT Version :10

• Sequence 1: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_988849.1
• Gene: sox17b / 394440
• XenbaseID: XB-GENE-484865
• Length: 376
• Species: Xenopus tropicalis
• Alignment Length: 480
• Identity: 130/480 - (27%)
• Similarity: 185/480 - (38%)
• Gaps: 151/480 - (31%)

  Fly   184 NC------GYLERHKPL----PADLKYRPGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENP 238
            ||      |..|...||    .|..|...|...|:...|:||||||||||||||.|||:||.:||
 Frog    17 NCSVPIMMGQYEWTDPLTMFQDAKTKKEAGSANSRGKAEARIRRPMNAFMVWAKDERKRLAQQNP 81

  Fly   239 DLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRKQSKLRAMQPGGKE 303
            |||||:|||||||.|:|||...:||:|||||||||.|:.::|:|||||||:||.|....:..|..
 Frog    82 DLHNAELSKMLGKSWKSLTLASKRPFVEEAERLRVQHIQDYPDYKYRPRRKKQVKRMKREEEGFL 146

  Fly   304 QSESSPNPGTGGSKSNPKLATPPLATASSSYTTPTDESTCNSTNQNHGQSTPGGLYE--QPLKPT 366
            .|...|.|...|..          |....:|     :...:..|....|.||.|.:|  .|:...
 Frog   147 PSADIPGPQVMGCN----------AMVGQNY-----KMQYSGQNSQQSQITPAGYFEDHNPVGYY 196

  Fly   367 YSPSSVDCYSNADSTEQIESLAANCPPALLNESSPTGGGYDNSLL--LKKLTKPSPSRAAKSRQE 429
            |...:|..|..:.::      :..|.|....|.......:::|.:  .:..:.|:..:....::.
 Frog   197 YRGYNVPEYYMSQNS------SVTCGPPAQGEYQALSYNFNSSYIPYQQNASAPAMGKQMAVKEN 255

  Fly   430 KLAKSEEKN-KGSQSQGQSQQG-IY----AATYPLAPTSVAVVAARGMYVTCNNRGLLDHGHSVK 488
            .:.:|.|.. .|.|...|...| :|    |.|:|:|.|.                   .|
 Frog   256 IIQESPEHGIMGCQVSPQMYNGQMYVPECAKTHPVAQTE-------------------QH----- 296

  Fly   489 GTFYPPVSVSEDDNSTSMRNSISALQQHCNVVTSTPSSSGGTMPTSEMSSYTVSMADNCGNLRLS 553
                                  |:|.|...:||               .:|..|..|  |:|...
 Frog   297 ----------------------SSLHQSQQMVT---------------QNYLPSQQD--GHLESD 322

  Fly   554 MNELSGNEYLPSANAYGMQYEDFLRYQSNDMDYSTSAVEHKETTSDSASGQKCLKYPDTNQNYD- 617
            :::              .:::.:|.|:...                           ||...|.
 Frog   323 IDK--------------TEFDQYLMYEPKS---------------------------DTELIYTI 346

  Fly   618 DYEAEAYSNAMLP-----ATAASYY 637
            |.::.|||..:||     |.:..||
 Frog   347 DQDSGAYSTNLLPSLISEANSVCYY 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	HMG-box_SoxF	214..289	CDD:438841	56/74 (76%)
		PHA03273	305..>391	CDD:223031	16/87 (18%)
sox17b	NP_988849.1	HMG-box_SoxF_SOX17	52..132	CDD:438850	57/79 (72%)
		PABP-1234	<80..250	CDD:130689	63/190 (33%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:Q9H6I2	326..334		1/7 (14%)
		Required for transcriptional activity and interaction with ctnnb1. /evidence=ECO:0000250|UniProtKB:O42601	327..331		0/3 (0%)