Protein Alignment Sox15 and HMGB1

DIOPT Version :10

• Sequence 1: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_002119.1
• Gene: HMGB1 / 3146
• HGNCID: 4983
• Length: 215
• Species: Homo sapiens
• Alignment Length: 111
• Identity: 31/111 - (27%)
• Similarity: 58/111 - (52%)
• Gaps: 4/111 - (3%)

  Fly   200 YRP--GGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRR 262
            |.|  |.|:.|....:..:||.:||.::....|.|:..|:|.|...|::|.||:.|.:....|::
Human    78 YIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQ 142

  Fly   263 PYVEEAERLRVIHMTEHPNY--KYRPRRRKQSKLRAMQPGGKEQSE 306
            ||.::|.:|:..:..:...|  |.:|...|:..::|.:...|::.|
Human   143 PYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEE 188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	HMG-box_SoxF	214..289	CDD:438841	22/76 (29%)
		PHA03273	305..>391	CDD:223031	1/2 (50%)
HMGB1	NP_002119.1	Sufficient for interaction with HAVCR2. /evidence=ECO:0000250|UniProtKB:P63158	1..97		5/18 (28%)
		LPS binding (delipidated). /evidence=ECO:0000269|PubMed:21660935	3..15
		HMG-box_HMGB_rpt1	8..76	CDD:438794
		Nuclear localization signal (NLS) 1. /evidence=ECO:0000250|UniProtKB:P63159	27..43
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..95		5/16 (31%)
		LPS binding (Lipid A). /evidence=ECO:0000269|PubMed:21660935	80..96		4/15 (27%)
		Cytokine-stimulating activity. /evidence=ECO:0000269|PubMed:12765338	89..108		4/18 (22%)
		HMG-box_HMGB_rpt2	93..163	CDD:438795	19/69 (28%)
		Binding to AGER/RAGE. /evidence=ECO:0000250|UniProtKB:P63159	150..183		6/32 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..215		7/28 (25%)
		Nuclear localization signal (NLS) 2. /evidence=ECO:0000250|UniProtKB:P63159	178..184		1/5 (20%)