DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox15 and sox11b

DIOPT Version :9

Sequence 1:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_571412.1	Gene:	sox11b / 30603	ZFINID:	ZDB-GENE-980526-466	Length:	368	Species:	Danio rerio

Alignment Length:	409	Identity:	99/409 - (24%)
Similarity:	173/409 - (42%)	Gaps:	105/409 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 PLPADLKYRPGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLT 257
            |:|      |.....|:| ...|:|||||||||:||||:|:.:::||:|||::||.|||:|:.|.
Zfish    31 PVP------PKPDWCKTA-TGHIKRPMNAFMVWSKIERRKIMEQSPDMHNAEISKRLGKRWKMLK 88

  Fly   258 PQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRKQSKLRAMQPGGKEQSESSPNPGTGGSKSNPKL 322
            ..::.|::.||||||:.||.::|:|||||::             |.:.:||..|..   :|..|:
Zfish    89 DSEKIPFIREAERLRLQHMADYPDYKYRPKK-------------KPKLDSSSKPAV---QSPEKI 137

  Fly   323 ATPPLATASSSYTTPTDESTCNSTNQNHGQSTPGGLYEQPLKPTYSPSSVDC-----YSNADSTE 382
            :....|.|...         |....    .|.||.:       |...|:.||     ::|...|:
Zfish   138 SKSVKAAAGKK---------CAKLK----PSKPGNI-------TARASTQDCRFNYVFTNLKVTK 182

  Fly   383 QIESLAANCPPALLNESSPTGGGYDNSLLLKKLTKPSPSRAAKSRQEKLAKSEEKNKGSQSQGQS 447
            .|:                           ::||.          .|.....::.:...:...:.
Zfish   183 SIK---------------------------RELTD----------DEDDDDDDDDDDDEEDDYED 210

  Fly   448 QQGIYAATYPLAPT-SVAVVAARG--MY-------VTCNNRGLLDHGHSVKGTFYPPVSVSEDDN 502
            ::.|.....|.:|| |.|..:..|  ||       .|..:|...:..:..|.:...|.|||...:
Zfish   211 EEHIRLHNVPASPTLSSAAESEHGASMYEESRHTSATPGSRLFYNFKNITKQSAAYPASVSPASS 275

  Fly   503 STSMRNSISALQQHCN--VVTSTPSSSGGTMPTSEMSSYTVSMADNCGNLRLSMNELSGNEYLPS 565
            ..|:.:|.|:..:..:  :|..:.:.:.|        |:|..:.:..|||.||:.:...:.:...
Zfish   276 FRSVSSSSSSSSEDSDDLLVDFSLNLAAG--------SHTADLGNTSGNLCLSLVDKDLDSFSEG 332

  Fly   566 ANAYGMQYEDFLRYQSNDM 584
            :.....::.|:...:.::|
Zfish   333 SLGSHFEFPDYCTPELSEM 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	39/70 (56%)
sox11b	NP_571412.1	SOX-TCF_HMG-box	45..112	CDD:238684	36/66 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910