DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox15 and tcf7l1a

DIOPT Version :9

Sequence 1:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_571344.1	Gene:	tcf7l1a / 30523	ZFINID:	ZDB-GENE-980605-30	Length:	560	Species:	Danio rerio

Alignment Length:	462	Identity:	97/462 - (20%)
Similarity:	157/462 - (33%)	Gaps:	155/462 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 EHPHHL-----LTNYNSKKY-----------------------PHVSR-TPEYSHSTGS--DYPE 41
            :||||:     |..|:::.:                       ||.|. :|.|..|.|:  ..|.
Zfish   165 QHPHHVHPLTPLITYSNEHFSPGTPPSHLSPEILDPKTGIPRTPHPSELSPYYPLSPGAVGQIPH 229

  Fly    42 HGGYLTDGRLMHESNSDAGIYHVRQGSEHSSPSLHSPAIQSSGYENEHLNEAVLAAHSHSHSPMP 106
            ..|:|...:..|..:...|      |..|..|:|...|..||      |..:..:.|...|.|..
Zfish   230 PLGWLVPQQGQHMYSIPPG------GFRHPYPALAMNASMSS------LVSSRFSPHMVPHPPHG 282

  Fly   107 MVSSAYVGGGTASGSLINSNIPLLGGGGNSVLNKFLSHPHAGMVGGGTGQMEDCTSHSPIEAASM 171
            :..:..                                ||..:|.....|  :....||
Zfish   283 LHQTGI--------------------------------PHPAIVSPAIKQ--EPNGESP------ 307

  Fly   172 WSYDYKGDLCAPNCGYLERHKPLPADLKYRPGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADE 236
             |....|....|                     .:.:..|:..|::|:||||::.|..|.|:..|
Zfish   308 -SNSTHGKPSVP---------------------VKKEEEKKPHIKKPLNAFMLYMKEMRAKVVAE 350

  Fly   237 NPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPR--RRKQSKLRAMQP 299
            .....:|.::::||::|.||:.:::..|.|.|.:.|.:|...:|.:..|..  :||:.| |..:.
Zfish   351 CTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYPGWSARDNYGKRKKRK-RDCKS 414

  Fly   300 GGKEQSESSPNPGTGGSKSNPKLATPPLATASSSYTTPTDESTCNSTNQNHGQ-----STPGGLY 359
            ....:|..||.|        .|...|.|::          |..|:|...:||.     :||....
Zfish   415 DSPSESNFSPQP--------KKQCVPYLSS----------EKMCDSPTSSHGSMLDSPATPSAAL 461

  Fly   360 EQPLKPTYSPSSVDCYSNADSTEQIESLAANCPP-----------ALLNESSPTGGGYDNSLLLK 413
            ..|..|.           |..:||.:.|:....|           .|..:||.:|.|  :|:.|.
Zfish   462 ASPAAPA-----------ATHSEQAQPLSLTTKPEGRAHHNHPHFPLPGKSSGSGSG--SSMALH 513

  Fly   414 KLTKPSP 420
            .|::|.|
Zfish   514 SLSRPIP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	22/70 (31%)
tcf7l1a	NP_571344.1	CTNNB1_binding	1..233	CDD:285538	14/67 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..328		7/60 (12%)
		SOX-TCF_HMG-box	328..399	CDD:238684	22/70 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..513		32/149 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	58	1.000	Inparanoid score	I5417
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.960