DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox15 and ste11

DIOPT Version :9

Sequence 1:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_596656.1	Gene:	ste11 / 2540258	PomBaseID:	SPBC32C12.02	Length:	468	Species:	Schizosaccharomyces pombe

Alignment Length:	566	Identity:	113/566 - (19%)
Similarity:	207/566 - (36%)	Gaps:	155/566 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 TQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAE 269
            |..:..::|.::||:|:||::    |:....|.|..::..:|:::|:.||:.:.|.::.|.:.:.
pombe     6 TAEQKDQKSSVKRPLNSFMLY----RRDRQAEIPTSNHQSISRIIGQLWRNESAQVKKYYSDLSA 66

  Fly   270 RLRVIHMTEHPNYKYRPRRRKQSKLRAMQPGGKEQSESSPNPGTGGSKSNPKLATPPLATASSSY 334
            ..|..||.|:|.|||.|::|...:.|          ....:|.:|...::..:....:|.:|.:.
pombe    67 LERQKHMLENPEYKYTPKKRSTVRRR----------HKKVSPSSGSFVASDYVVLQQIAQSSKTL 121

  Fly   335 TTPTDESTCNSTNQNHGQSTPGGLYEQPLKPTYSPSSVDCYSNADSTEQIESLAANCPPALLNES 399
            .....|...|.              |:.|....:|:.  .|..:..:..||:...:|     ..|
pombe   122 KQTEPEKPVNE--------------EETLAALLAPAL--SYPKSGKSNLIETSELSC-----LSS 165

  Fly   400 SPTGGGYDNSLLLKKLTKPSPS--RAAKSRQEKLAKSEEKNKGSQSQGQSQQGIY----AATYPL 458
            ||         :::..|.||.|  ....:....|.|||        |..|..|||    ::..|:
pombe   166 SP---------MIRSHTIPSLSFTDQVSTTISTLDKSE--------QAPSSLGIYYRSPSSGSPI 213

  Fly   459 APTSVAVVAARGMYV---TCNNRGLLDHGHSVKGT---------------------FYPPVSVSE 499
            ..|....:|.:...|   :.::.|.:|..:.:..|                     |....:|||
pombe   214 GRTKSVCLANKARIVPKRSMSSDGCVDKSYQMSKTPSLEANLPQNSSNCSARRVPKFDSKGTVSE 278

  Fly   500 DDNSTSMRNSISALQQHCNVVTSTPSSSGGTMPTSEMSSYTVSMADNCGNLRLSMNELSGNEYLP 564
            ..||.|...|...:..||:.:.:.||:.  :.|.:.:|..|.:..|:.|        ..|.|||.
pombe   279 QSNSDSPELSADKVLSHCSPIDARPSTP--SCPNASISPKTPNTGDHYG--------FDGAEYLG 333

  Fly   565 SANAYGMQYEDFLRYQSNDMDYSTSAVEHKETTSDSASGQKCLKYPDTNQNYDDYEAEAYSNAML 629
            :..:.|                ||:|..:.:.|       :.|..|..:.:|.         ||.
pombe   334 TPLSVG----------------STTAYLYGQET-------ELLSTPYCHTSYP---------AMS 366

  Fly   630 PATAASYYTQLPYPPTSLAAFPLQLAVPFQQTTSGAYGAQPIQSGYLHYGNY-------GGYEGM 687
            ...::|.||.:.....:.:.          .|.:..:.:.....|::...::       |.||..
pombe   367 RLNSSSGYTCVSSSSVTNSG----------HTENNTWRSDEQSKGFVDINSFSQSLFSNGNYEFA 421

  Fly   688 AQSQPQNQA-----------PVHHQ-QASHSAPPSLSVP--PNQTV 719
            |.||..:..           |:... :.::|..|||..|  ||..:
pombe   422 AHSQELDDLFSQITDFTSTDPIASSLKDANSLGPSLLEPWLPNSNL 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	21/70 (30%)
ste11	NP_596656.1	MATA_HMG-box	16..87	CDD:238685	23/74 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm47091
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810