Protein Alignment Sox15 and Sry

DIOPT Version :10

• Sequence 1: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_035694.1
• Gene: Sry / 21674
• MGIID: 98660
• Length: 395
• Species: Mus musculus
• Alignment Length: 90
• Identity: 44/90 - (48%)
• Similarity: 68/90 - (75%)
• Gaps: 2/90 - (2%)

  Fly   212 ESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHM 276
            |..::|||||||||::.||.|||.:||.:.|.::||.||.:|:|||..::||:.:||:||:::|.
Mouse     2 EGHVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKILHR 66

  Fly   277 TEHPNYKYRPRRRKQSKLRA--MQP 299
            .::|||||:|.||.:...|:  :||
Mouse    67 EKYPNYKYQPHRRAKVSQRSGILQP 91

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	HMG-box_SoxF	214..289	CDD:438841	38/74 (51%)
		PHA03273	305..>391	CDD:223031
Sry	NP_035694.1	Sufficient for interaction with KPNB1. /evidence=ECO:0000250|UniProtKB:Q05066	4..81		40/76 (53%)
		HMG-box_SoxA_SoxB_SoxG	4..79	CDD:438837	38/74 (51%)
		Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066	6..22		11/15 (73%)
		Sufficient for interaction with EP300. /evidence=ECO:0000250|UniProtKB:Q05066	52..84		15/31 (48%)
		Required for nuclear localization. /evidence=ECO:0000250|UniProtKB:Q05066	75..81		3/5 (60%)
		Necessary for interaction with ZNF208 isoform KRAB-O. /evidence=ECO:0000269|PubMed:15469996	92..144		44/90 (49%)
		Necessary for interaction with SLC9A3R2 and nuclear accumulation of SLC9A3R2. /evidence=ECO:0000269|PubMed:16166090	94..138
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..361