DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox15 and Sox8

DIOPT Version :9

Sequence 1:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_035577.1	Gene:	Sox8 / 20681	MGIID:	98370	Length:	464	Species:	Mus musculus

Alignment Length:	585	Identity:	156/585 - (26%)
Similarity:	210/585 - (35%)	Gaps:	192/585 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 GGGTGQMEDCTSHSPIEAASMWSYDYKGDLCAPNC------GYLERHKPLPADLKYRPGGTQSKS 209
            |||.|        ...|||     |.:...|..:.      ||.....|:|.    |.||..:..
Mouse    47 GGGRG--------DTAEAA-----DERFPACIRDAVSQVLKGYDWSLVPMPV----RGGGGGTLK 94

  Fly   210 AKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVI 274
            || ..::||||||||||:..|:||||:.|.||||:|||.|||.||.|:..::||:|||||||||.
Mouse    95 AK-PHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQ 158

  Fly   275 HMTEHPNYKYRPRRRKQSKLRAMQPGGKEQSESSPNPG--TGGSKSNPKLATPPLATASSSYTTP 337
            |..:||:|||:|||||..|.      |:..|:|....|  .||          |:..|.:.....
Mouse   159 HKKDHPDYKYQPRRRKSVKT------GRSDSDSGTELGHHPGG----------PMYKADAVLGEA 207

  Fly   338 TDESTCNSTNQNHGQSTPGGLYEQPLKPTYSPSSVDCYSNADSTEQIESLAANCPPALLNESSPT 402
            ...|. :.|.|.||..||         ||...:.:...||.
Mouse   208 HHHSD-HHTGQTHGPPTP---------PTTPKTDLHQASNG------------------------ 238

  Fly   403 GGGYDNSLLLKKLTKPSPSRAAKSRQEKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSVAVVA 467
                                         :|.|.:.:|.:.....:|.|..:...::..|..|:
Mouse   239 -----------------------------SKQELRLEGRRLVDSGRQNIDFSNVDISELSSEVI- 273

  Fly   468 ARGMYVTCNNRGLLDHGHSVKGTFYPPVSVSEDDNSTSMRNSISALQQHCNVVTSTPSSSGGTMP 532
                              |...||    .|.|.|....: |..|||....:..|::.|..|
Mouse   274 ------------------SNMDTF----DVHEFDQYLPL-NGHSALPTEPSQATASGSYGG---- 311

  Fly   533 TSEMSSYTVSMADNCGNLRLSMNELSGNEYLPSANAYGMQYEDFLRYQSNDMDYSTSAVEHKETT 597
                :||:.|.|...|     .:.:..::..|||:|...:... ||.|......|.|   |....
Mouse   312 ----ASYSHSGATGIG-----ASPVWAHKGAPSASASPTEAGP-LRPQIKTEQLSPS---HYNDQ 363

  Fly   598 SDSASGQKCLKYPDTNQNYDDYEAEAYSNAMLPATAASYYTQLPYPPTSLAAFPLQLAVPFQQTT 662
            |..:.|:         .:|..|.|:|.......|||||.:.......|.|.|
Mouse   364 SHGSPGR---------ADYGSYSAQASVTTAASATAASSFASAQCDYTDLQA------------- 406

  Fly   663 SGAYGAQPIQSGYLHYGNYGGYEGMAQSQPQN--QAPVHHQQASHSAPP---SLSVPPNQTVTSN 722
                      |.|  |..|.||       |.:  |.|..|......|.|   .||:||..:.:||
Mouse   407 ----------SNY--YSPYPGY-------PPSLYQYPYFHSSRRPYASPLLNGLSMPPAHSPSSN 452

Fly 723 722
Mouse 453 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	45/70 (64%)
Sox8	NP_035577.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		4/15 (27%)
		Sox_N	18..86	CDD:315171	13/55 (24%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P57073	55..97		14/51 (27%)
		SOX-TCF_HMG-box	98..168	CDD:238684	44/69 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..244		37/168 (22%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P57073	221..299		23/163 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..315		7/30 (23%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P57073	347..464		37/150 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..374		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..464		4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810