Protein Alignment Sox15 and Sox17

DIOPT Version :10

• Sequence 1: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_035571.1
• Gene: Sox17 / 20671
• MGIID: 107543
• Length: 419
• Species: Mus musculus
• Alignment Length: 532
• Identity: 155/532 - (29%)
• Similarity: 194/532 - (36%)
• Gaps: 176/532 - (33%)

  Fly   142 LSHPHAGMVGGGTGQMEDCTSHSPIEAASMWSYDYKGDLCAPNCGYLERHKPLPADLKYR----- 201
            :|.|.||.......|..   |..|...|.:          .| |.:.|...|| .|:|.:
Mouse     1 MSSPDAGYASDDQSQPR---SAQPAVMAGL----------GP-CPWAESLSPL-GDVKVKGEVVA 50

  Fly   202 ----PGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRR 262
                |.||..::..||||||||||||||||.|||:||.:|||||||:|||||||.|::||..::|
Mouse    51 SSGAPAGTSGRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKR 115

  Fly   263 PYVEEAERLRVIHMTEHPNYKYRPRRRKQSKLRAMQPGGKEQSESSPNPGTGGSK---------- 317
            |:|||||||||.||.:|||||||||||||.|......||...:...|..|..|.:
Mouse   116 PFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRVEGGFLHALVEPQAGALGPEGGRVAMDGLG 180

  Fly   318 ---------SNPKLATPPL-----------ATASSSYTTPT-DESTCNSTNQN--------HGQS 353
                     :.|.|.:|.:           |.|...|..|| |.|..:...|:        .|..
Mouse   181 LPFPEPGYPAGPPLMSPHMGPHYRDCQGLGAPALDGYPLPTPDTSPLDGVEQDPAFFAAPLPGDC 245

  Fly   354 TPGGLYEQPLKPTYSPSSVDCYSNADSTEQIESLAANCPPALLNESSPTGGGYDNSLLLKKLTKP 418
            ...|.|      ||:|.|       |....:|      |||     .|...|            |
Mouse   246 PAAGTY------TYAPVS-------DYAVSVE------PPA-----GPMRVG------------P 274

  Fly   419 SPSRAAKSRQEKLAKSEEKNKGSQSQGQSQQGIYAATYPL-----APTSVAVVAARGMYVTCNNR 478
            .||                       |.:..||.|....|     |..|.|..|.||.:.
Mouse   275 DPS-----------------------GPAMPGILAPPSALHLYYGAMGSPAASAGRGFHA----- 311

  Fly   479 GLLDHGHSVKGTFYPPVSVSEDDNSTSMRNSISALQQHCNVVTSTPSSSGGTMPTSEMSSYTVSM 543
               .....::....||                ...|||.......||.....:|..:
Mouse   312 ---QPQQPLQPQAPPP----------------PPQQQHPAHGPGQPSPPPEALPCRD-------- 349

  Fly   544 ADNCGNLRLSMNELSG-------NEYLPSANAYGMQYEDFLRYQSND--MDYSTSAVEHKETTSD 599
                |.......||.|       .:|||    :..:.|..|.||.:|  ::.|.|........||
Mouse   350 ----GTESNQPTELLGEVDRTEFEQYLP----FVYKPEMGLPYQGHDCGVNLSDSHGAISSVVSD 406

  Fly   600 SASGQKCLKYPD 611
            ::|......|||
Mouse   407 ASSAVYYCNYPD 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	HMG-box_SoxF	214..289	CDD:438841	58/74 (78%)
		PHA03273	305..>391	CDD:223031	23/124 (19%)
Sox17	NP_035571.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		8/28 (29%)
		HMG-box_SoxF_SOX17	62..142	CDD:438850	60/79 (76%)
		Sox17_18_mid	203..253	CDD:463454	11/55 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..356		12/88 (14%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:Q9H6I2	366..374		3/11 (27%)