DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sox15 and Sox12

DIOPT Version :10

Sequence 1:NP_523739.2 Gene:Sox15 / 36575 FlyBaseID:FBgn0005613 Length:784 Species:Drosophila melanogaster
Sequence 2:NP_035568.1 Gene:Sox12 / 20667 MGIID:98360 Length:314 Species:Mus musculus


Alignment Length:296 Identity:80/296 - (27%)
Similarity:129/296 - (43%) Gaps:83/296 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   202 PG-GTQSKSAKE--------SRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLT 257
            || |..::.|:|        ..|:|||||||||::.||:|:.|:.||:|||::||.||::|:.|.
Mouse    18 PGPGPAAEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQ 82

  Fly   258 PQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRKQ---SKLRAMQPGGKEQSESSPNPGTGGSKSN 319
            ..::.|:|.||||||:.||.::|:||||||::.:   :|.|...|||          |.|||:..
Mouse    83 DSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGG----------GGGGSRLK 137

  Fly   320 PKLATP----------PLATASSSYTTPTDES-----------TCNSTNQNHGQSTPGGLYEQ-P 362
            |....|          ||...:::   |.|:.           ...:..:...:..|.|...: |
Mouse   138 PGPQLPGRGGRRASGGPLGGGAAA---PEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGP 199

  Fly   363 LKPTYSPSSVDCYSNADSTEQIESLAANCPPALLNESSPTGGGYDNSLLLKKLTKPSPSRAAKSR 427
            .:....||.....::|.|            |.|..:..|                       :..
Mouse   200 AERAQGPSGEGAAASAAS------------PTLSEDEEP-----------------------EEE 229

  Fly   428 QEKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSV 463
            :|:.|.:||..:.:...|:...| :.:..|..|..:
Mouse   230 EEEAATAEEGEEETVVSGEEPLG-FLSRMPPGPAGL 264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox15NP_523739.2 HMG-box_SoxF 214..289 CDD:438841 42/74 (57%)
PHA03273 305..>391 CDD:223031 17/107 (16%)
Sox12NP_035568.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 5/21 (24%)
HMG-box_SoxC_SOX12 29..116 CDD:438847 43/86 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 101..287 41/213 (19%)
Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000269|PubMed:18403418 282..314
Blue background indicates that the domain is not in the aligned region.

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