DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox15 and Sox10

DIOPT Version :9

Sequence 1:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_035567.1	Gene:	Sox10 / 20665	MGIID:	98358	Length:	466	Species:	Mus musculus

Alignment Length:	522	Identity:	149/522 - (28%)
Similarity:	214/522 - (40%)	Gaps:	130/522 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 ENEHLNEAVLAAHSHSHSPMPMVSSAYVGGGTASGSLINSNIPLL---GGGGNSVLNKFLSHPHA 147
            |.:.|:|..|       ||:.......:..|:|         |.|   ||||.|.|.   :.|..
Mouse     3 EEQDLSEVEL-------SPVGSEEPRCLSPGSA---------PSLGPDGGGGGSGLR---ASPGP 48

  Fly   148 GMVGGGTGQMEDCTSHS---PI---EAASMWSYDYKGDLCAPNCGYLERHKPLPADLKYRPGGTQ 206
            |.:|....:.:|..:..   |:   ||.|.....|...|.           |:|..:.   |.::
Mouse    49 GELGKVKKEQQDGEADDDKFPVCIREAVSQVLSGYDWTLV-----------PMPVRVN---GASK 99

  Fly   207 SKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERL 271
            ||    ..::||||||||||:..|:||||:.|.||||:|||.|||.||.|...|:||::||||||
Mouse   100 SK----PHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERL 160

  Fly   272 RVIHMTEHPNYKYRPRRRKQSKL---RAMQPGGK-EQSESS---------------PNPGTGGSK 317
            |:.|..:||:|||:|||||..|.   .|..|||: ||..::               |..|:..|.
Mouse   161 RMQHKKDHPDYKYQPRRRKNGKAAQGEAECPGGEAEQGGAAAIQAHYKSAHLDHRHPEEGSPMSD 225

  Fly   318 SNPKLATPPLATASSSYTTPTDESTCNSTNQNHGQSTP---------GGLYEQPLKPTYSPSSVD 373
            .||:      ..:..|:..||..:| ..|....|::.|         ||      ||.....:||
Mouse   226 GNPE------HPSGQSHGPPTPPTT-PKTELQSGKADPKRDGRSLGEGG------KPHIDFGNVD 277

  Fly   374 -------CYSNA---DSTEQIESLAANCPPALLNESSPTGGGYDNSLLLKK-----LTKP----- 418
                   ..||.   |.||..:.|..|..|..:...|..|.|..::|.:..     ::||
Mouse   278 IGEISHEVMSNMETFDVTELDQYLPPNGHPGHVGSYSAAGYGLGSALAVASGHSAWISKPPGVAL 342

  Fly   419 ---SPSRAAKSRQEKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSVAVVAARGMYVTCNNRGL 480
               ||....       ||::.|.:.:..||........:|..:|.||:: :...|......:|..
Mouse   343 PTVSPPGVD-------AKAQVKTETTGPQGPPHYTDQPSTSQIAYTSLS-LPHYGSAFPSISRPQ 399

  Fly   481 LDHG-HSVKGTFYPPVSVSEDDNSTSMRNSISAL---QQHCNVVTSTPSSSG--GTMPTS-EMSS 538
            .|:. |...|.:|     .....::.:.::.|.:   |:......|.||.||  ...||. |...
Mouse   400 FDYSDHQPSGPYY-----GHAGQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPTHWEQPV 459

  Fly   539 YT 540
            ||
Mouse   460 YT 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	44/70 (63%)
Sox10	NP_035567.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		20/82 (24%)
		Sox_N	12..93	CDD:403592	25/110 (23%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P56693	62..102		11/57 (19%)
		SOX-TCF_HMG-box	103..173	CDD:238684	43/69 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..200		20/39 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..275		16/74 (22%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P56693	228..310		22/94 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..375		7/37 (19%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P56693	353..466		26/115 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..466		10/29 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810