Protein Alignment Sox15 and Sox9

DIOPT Version :10

• Sequence 1: NP_523739.2
• Gene: Sox15 / 36575
• FlyBaseID: FBgn0005613
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_536328.1
• Gene: Sox9 / 140586
• RGDID: 620474
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 617
• Identity: 157/617 - (25%)
• Similarity: 216/617 - (35%)
• Gaps: 181/617 - (29%)

  Fly   101 SHSPMPMVSSAYVGGGTASGSLINSNIPLLGGGGNSVLNKFLSHPHAGMVGGGTGQM--EDCTSH 163
            |.:|.|.:|....|....|||            |:...|   :.|.......|...:  |.....
  Rat    19 SGAPSPTMSEDSAGSPCPSGS------------GSDTEN---TRPQENTFPKGEPDLKKESEEDK 68

  Fly   164 SPI---EAASMWSYDYKGDLCAPNCGYLERHKPLPADLKYRPGGTQSKSAKESRIRRPMNAFMVW 225
            .|:   ||.|.....|...|.           |:|.    |..|:   |..:..::|||||||||
  Rat    69 FPVCIREAVSQVLKGYDWTLV-----------PMPV----RVNGS---SKNKPHVKRPMNAFMVW 115

  Fly   226 AKIERKKLADENPDLHNADLSKMLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRK 290
            |:..|:||||:.|.||||:|||.|||.||.|...::||:|||||||||.|..:||:|||:|||||
  Rat   116 AQAARRKLADQYPHLHNAELSKTLGKLWRLLNESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRK 180

  Fly   291 QSKL-RAMQPGGKEQSESSPN----------------------PG--TGGSKSNPKLATPPLATA 330
            ..|. :|......||:..|||                      ||  :|.|:..|   |||
  Rat   181 SVKNGQAEAEEATEQTHISPNAIFKALQADSPHSSSGMSEVHSPGEHSGQSQGPP---TPP---- 238

  Fly   331 SSSYTTP-TDESTCNSTNQNHGQSTPGGLYEQPL---KPTYSPSSVDCYSNADSTEQIESLAANC 391
                ||| ||........:..|:....|..:.|:   .......|.|..||.: |..:.......
  Rat   239 ----TTPKTDVQAGKVDLKREGRPLAEGGRQPPIDFRDVDIGELSSDVISNIE-TFDVNEFDQYL 298

  Fly   392 P-------PALLNESSPTGGGYDNSLLLKKLTKPSPSRAAKSRQEKLAKSEEKNKGSQSQGQSQQ 449
            |       ||...:.|.||....:|      |.|:|:.|.   ...::|.:......|...|:.|
  Rat   299 PPNGHPGVPATHGQVSYTGSYGISS------TAPTPATAG---HVWMSKQQAPPPPPQQPPQAPQ 354

  Fly   450 GIYAATYPLAPTSVAVVAARGMYVTCNNRGLLDHGHSVKGTFYPPVSVSEDDNSTSMRNSISALQ 514
            .      |.||.....                           ||            :...:..|
  Rat   355 A------PQAPPQQQA---------------------------PP------------QPQQAPQQ 374

  Fly   515 QHCNVVTSTPSSSGGT----MPTSEMSSYTVSMADNCGNLRLSMNELSGNEYLPSANAYGMQYED 575
            |..:.:|:..|..|.:    :.|.::|....|........::|.:..:...|.||.........|
  Rat   375 QQAHTLTTLSSEPGQSQRTHIKTEQLSPSHYSEQQQHSPQQISYSPFNLPHYNPSYPTITRSQYD 439

  Fly   576 FLRYQSNDMDYSTSAVEHKETTSDSASGQKCLKYPDTNQNYDDYEAEAYSNAMLPATAASYYTQL 640
            :..:|::...||.:|                      .|....|....|.|   ||....|   .
  Rat   440 YTDHQNSGSYYSHAA----------------------GQGSGLYSTFTYMN---PAQRPMY---T 476

  Fly   641 PYPPTSLAAFPLQLAVP-FQQTTSGAYGAQPI 671
            |...||        .|| ..||.|..:..||:
  Rat   477 PIADTS--------GVPSIPQTHSPQHWEQPV 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	HMG-box_SoxF	214..289	CDD:438841	48/74 (65%)
		PHA03273	305..>391	CDD:223031	24/113 (21%)
Sox9	NP_536328.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..67		13/62 (21%)
		Sox_N	22..94	CDD:463586	20/101 (20%)
		Dimerization (DIM). /evidence=ECO:0000250|UniProtKB:P48436	63..103		12/57 (21%)
		PQA. /evidence=ECO:0000250|UniProtKB:P48436	63..103		12/57 (21%)
		HMG-box_SoxE	104..178	CDD:438840	47/73 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	160..250		35/100 (35%)
		Transactivation domain (TAM). /evidence=ECO:0000250|UniProtKB:P48436	224..307		22/94 (23%)
		9aaTAD 1. /evidence=ECO:0000250|UniProtKB:P48436	275..284		2/8 (25%)
		9aaTAD 2. /evidence=ECO:0000250|UniProtKB:P48436	290..298		0/7 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..429		19/138 (14%)
		Transactivation domain (TAC). /evidence=ECO:0000250|UniProtKB:P48436	392..507		29/145 (20%)
		9aaTAD 3. /evidence=ECO:0000250|UniProtKB:P48436	458..466		1/7 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	477..507		10/32 (31%)