DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox15 and sox18

DIOPT Version :9

Sequence 1:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001123409.1	Gene:	sox18 / 100170185	XenbaseID:	XB-GENE-483233	Length:	362	Species:	Xenopus tropicalis

Alignment Length:	350	Identity:	114/350 - (32%)
Similarity:	159/350 - (45%)	Gaps:	102/350 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 PNCGYLERHKPLPADLKYRPGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSK 247
            |..||        :..:.:||        :.||||||||||||||.|||:||.:|||||||.|||
Frog    52 PGYGY--------SPCEEKPG--------DPRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSK 100

  Fly   248 MLGKKWRSLTPQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRKQS-KLRAMQPGGKEQSESSP-- 309
            |||:.|::|:..::||:|||||||||.|:.:||||||||||:||: ||:.:.|        ||
Frog   101 MLGQSWKNLSSAEKRPFVEEAERLRVQHLQDHPNYKYRPRRKKQAKKLKRVDP--------SPLL 157

  Fly   310 -NPGTGGSKSNPKLA----TPPLATAS--SSYTTPTDESTCNSTNQNHGQSTPGGLYEQPLKPTY 367
             |.|..| ::...|:    ..||..:.  .||..||.|            .:|..:.| |.:|.:
Frog   158 RNEGYRG-QAMANLSHFRDLHPLGGSGDLESYGLPTPE------------MSPLDVVE-PSEPAF 208

  Fly   368 SP----------------SSVDCYSNADSTEQIESLAANCPPALLNE--SSPTG--------GGY 406
            .|                ..|| :....:..:| ||..:..|:.:..  .:||.        ||.
Frog   209 FPPHMREEADPGPFRTYQHGVD-FGQEKTLREI-SLPYSSSPSHMGGFLRTPTASAFYYNPHGGS 271

  Fly   407 DNSLLLKKLTKPSPSRAAKSRQEKLAKSE-----EKNKGSQSQGQSQ-QGIYAATYPL------A 459
            .....|.:|: |.|...|....:.|..:|     ::|:..|....|: ||   ..||.      |
Frog   272 PACTPLGQLS-PPPEAPALEAMDHLGPAELWGDFDRNEFDQYLNMSRTQG---PGYPFPMSKLGA 332

  Fly   460 PTSVAVV----------AARGMYVT 474
            |.::...          |:..||.|
Frog   333 PRTIPCEESSLISALSDASTAMYYT 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	51/70 (73%)
sox18	NP_001123409.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68		5/31 (16%)
		SOX-TCF_HMG-box	67..138	CDD:238684	51/70 (73%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	70..83		11/12 (92%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	94..106		9/11 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..159		17/37 (46%)
		Important for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:P43680	149..209		18/81 (22%)
		Sox17_18_mid	173..222	CDD:371880	12/61 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5873
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	1	1.000	-	-		otm47877
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.040