DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sox15 and sox10

DIOPT Version :9

Sequence 1:	NP_523739.2	Gene:	Sox15 / 36575	FlyBaseID:	FBgn0005613	Length:	784	Species:	Drosophila melanogaster
Sequence 2:	NP_001093691.1	Gene:	sox10 / 100101700	XenbaseID:	XB-GENE-480304	Length:	436	Species:	Xenopus tropicalis

Alignment Length:	391	Identity:	117/391 - (29%)
Similarity:	174/391 - (44%)	Gaps:	77/391 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 PLPADLKYRPGGTQSKSAKESRIRRPMNAFMVWAKIERKKLADENPDLHNADLSKMLGKKWRSLT 257
            |:|..:.   ||::||    ..::||||||||||:..|:||||:.|.||||:|||.|||.||.|.
Frog    75 PMPVRVN---GGSKSK----PHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLN 132

  Fly   258 PQDRRPYVEEAERLRVIHMTEHPNYKYRPRRRKQSKLRAMQPGGKEQSESSPNPGTGGSKSNPKL 322
            ..|:||::|||||||:.|..:||:|||:|||||..|               ||||.|...|.
Frog   133 ENDKRPFIEEAERLRMQHKKDHPDYKYQPRRRKNGK---------------PNPGEGDGSSE--- 179

  Fly   323 ATPPLATASSSY----------TTPTDESTCNSTNQNHGQSTPGGLYEQPLKPTYSPSSVD---- 373
            |....|:..:.|          :..:|.::.:|..|:||..||....:..|:...|....|
Frog   180 AEGGAASIQAHYKNSHLDHRHGSPMSDGNSEHSAGQSHGPPTPPTTPKTELQAGKSDGKRDGSRS 244

  Fly   374 ---------CYSNADSTEQIESLAANCPPALLNESS----PTG--------GGYDNSLLLKKLTK 417
                     .:.|.|..|....:.||.....:||..    |.|        |||.:|..|.....
Frog   245 LGEGGKPHIDFGNVDIGEISHDVMANMETFDVNEFDQYLPPNGHAGHPSHIGGYTSSYGLSGALA 309

  Fly   418 PSPS--RAAKSRQEKLAKSEEKNKGSQSQGQSQQGIYAATYPLAPTSVAVVAARGMYVTCNNRGL 480
            ..||  ..||...:..:|::.|.:.|.:...::|   .:|..|..||:. :...|......:|..
Frog   310 AGPSAWALAKQHPQTDSKAQVKTESSSTSHYTEQ---PSTSQLTYTSLG-LPHYGSAFPSISRPQ 370

  Fly   481 LDHG-HSVKGTFYPPVSVSEDDNSTSMRNSISAL----QQHCNVVTSTPSSSGGTMPTS-EMSSY 539
            .|:. |....::|     |....::|:.::.|.:    :.....::.:||.:....||. |...|
Frog   371 FDYADHQPSSSYY-----SHSSQASSLYSAFSYMGPPQRPLYTAISDSPSVAQSHSPTHWEQPVY 430

  Fly   540 T 540
            |
Frog   431 T 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox15	NP_523739.2	SOX-TCF_HMG-box	214..285	CDD:238684	44/70 (63%)
sox10	NP_001093691.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Sox_N	12..79	CDD:372113	2/3 (67%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P56693	48..88		6/19 (32%)
		SOX-TCF_HMG-box	89..159	CDD:238684	43/69 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..183		22/55 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..257		10/61 (16%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P56693	209..295		18/85 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..346		4/26 (15%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P56693	327..436		23/114 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..436		7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910