DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and AVT3

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_012776.1	Gene:	AVT3 / 853710	SGDID:	S000001629	Length:	692	Species:	Saccharomyces cerevisiae

Alignment Length:	460	Identity:	87/460 - (18%)
Similarity:	170/460 - (36%)	Gaps:	62/460 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 GEYRNEYQSTSFNEYDGRYQQTDGFRQGSIASEGSSFVCEGEGGGGCKIDEFQAAWNVTNAIQGM 157
            |.:..|..|....|.:...::.:   :.::.:|.:..|....|....|....:|...:..:..|.
Yeast   252 GHFAGEDLSEEEEEEEETEEEPE---EEALETESTQLVSREHGRHPHKSSTVKAVLLLLKSFVGT 313

  Fly   158 FIVSLPFAVLHGGYWAIVAMVGIAHICCYTGKVLVQCLYEPDPATGQMVRVRDSYVAIAKVCFGP 222
            .::.||.| .|.|.|      |.:.:|..:..::....:.....|...|.| |.|..:.::.:||
Yeast   314 GVLFLPKA-FHNGGW------GFSALCLLSCALISYGCFVSLITTKDKVGV-DGYGDMGRILYGP 370

  Fly   223 KLGARAVSIAQLIELLMTCILYVVVCGDLLAGT-----YPQGSFDSRSWMLFVGIFLLPMGFLKS 282
            |:....:|...|.::..:....|....:|...:     ...||....:::....:..:|:...::
Yeast   371 KMKFAILSSIALSQIGFSAAYTVFTATNLQVFSENFFHLKPGSISLATYIFAQVLIFVPLSLTRN 435

  Fly   283 LKMVSTLS--------------FWCTMSHIVINAVILGYCLL-QIGDWGWSKVRFSIDMENFPIS 332
            :..:|..:              :..::.:|.:|.|.....|: ...||.              :.
Yeast   436 IAKLSGTALIADLFILLGLVYVYVYSIYYIAVNGVASDTMLMFNKADWS--------------LF 486

  Fly   333 LGVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAAAVFKAGFGYICFLTFQNDTQQVITNNL 397
            :|..:|::.....|..::.:|.....|...|.......||.....|.:|:..|.:|.:.|:..|.
Yeast   487 IGTAIFTFEGIGLLIPIQESMKHPKHFRPSLSAVMCIVAVIFISCGLLCYAAFGSDVKTVVLLNF 551

  Fly   398 -HSQGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKF-PTI-WNLDGELKVWGLGF 459
             ....:...|.....:..|||.||..:.|..:||...|......|: |.: |     ||.:   |
Yeast   552 PQDTSYTLTVQLLYALAILLSTPLQLFPAIRILENWTFPSNASGKYNPKVKW-----LKNY---F 608

  Fly   460 RVGVIVSTILMA-IFIPHFSILMGFIGSFTGTMLSFIWPCYFHIK---IKGHLLDQKEIAKDYLI 520
            |..::|.|.::| :........:..:|||....|.:|:|...|.|   :.|  ..:..:..|.::
Yeast   609 RCAIVVLTSILAWVGANDLDKFVSLVGSFACIPLIYIYPPLLHYKASILSG--TSRARLLLDLIV 671

  Fly   521 IGLGV 525
            |..||
Yeast   672 IVFGV 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	79/409 (19%)
AVT3	NP_012776.1	Aa_trans	295..687	CDD:279788	80/414 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810