DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and Slc32a1

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_113970.1	Gene:	Slc32a1 / 83612	RGDID:	621402	Length:	525	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	219/470 - (46%)
Similarity:	301/470 - (64%)	Gaps:	24/470 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 NDGEGGGDGDGEYRNEYQSTSFNEYDGRYQQTDGFRQGS-IASEGSSFVCEGEGG--GG---CKI 141
            ::||..||...|        ...|.|..||     |.|: :...||.....|.||  ||   .||
  Rat    65 SEGEPCGDEGAE--------PPVEGDIHYQ-----RGGAPLPPSGSKDQAVGAGGEFGGHDKPKI 116

  Fly   142 DEFQAAWNVTNAIQGMFIVSLPFAVLHGGYWAIVAMVGIAHICCYTGKVLVQCLYEPDPATGQMV 206
            ..::|.|||||||||||::.||:|:|||||..:..::..|.:||||||:|:.|||| :...|::|
  Rat   117 TAWEAGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYE-ENEDGEVV 180

  Fly   207 RVRDSYVAIAKVCFGPK---LGARAVSIAQLIELLMTCILYVVVCGDLLAGTYPQGSFDSRSWML 268
            ||||||||||..|..|:   ||.|.|::||:|||:|||||||||.|:|:..::|......:||.:
  Rat   181 RVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELVMTCILYVVVSGNLMYNSFPGLPVSQKSWSI 245

  Fly   269 FVGIFLLPMGFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGDWGWSKVRFSIDMENFPISL 333
            .....|||..|||:||.||..|..||::|.|||.:::.|||.:..||.|.||:|.||::.||||:
  Rat   246 IATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWEKVKFYIDVKKFPISI 310

  Fly   334 GVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAAAVFKAGFGYICFLTFQNDTQQVITNNLH 398
            |:||||||||||||:|||||...|:|:.|::|:||||.|.|..|..:.:||:.::|::|||:||.
  Rat   311 GIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACVLKGLFALVAYLTWADETKEVITDNLP 375

  Fly   399 SQGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKFPTIWNLDGELKVWGLGFRVGV 463
            . ..:.:||.|||.|||||||||::||.|:||::.|:...:..||..:..||.||.|||..|..:
  Rat   376 G-SIRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEGSRAFFPACYGGDGRLKSWGLTLRCAL 439

  Fly   464 IVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIKIKGHLLDQKEIAKDYLIIGLGVLFG 528
            :|.|:||||::|||::|||..||.||..|.|:.|..||:::....|...::..|..|..:|.:..
  Rat   440 VVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQVFFDVAIFVIGGICS 504

  Fly   529 VIGIYDSGNALINAF 543
            |.|...|...||.|:
  Rat   505 VSGFVHSLEGLIEAY 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	195/391 (50%)
Slc32a1	NP_113970.1	Aa_trans	115..512	CDD:279788	197/398 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352528
Domainoid	1	1.000	403	1.000	Domainoid score	I704
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56451
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1809
OMA	1	1.010	-	-		QHG52048
OrthoDB	1	1.010	-	-		D321223at33208
OrthoFinder	1	1.000	-	-		FOG0007337
OrthoInspector	1	1.000	-	-		oto95463
orthoMCL	1	0.900	-	-		OOG6_100570
Panther	1	1.100	-	-	LDO	PTHR48017
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X361
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770