DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and Slc38a10

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	XP_006534347.1	Gene:	Slc38a10 / 72055	MGIID:	1919305	Length:	1111	Species:	Mus musculus

Alignment Length:	409	Identity:	95/409 - (23%)
Similarity:	171/409 - (41%)	Gaps:	66/409 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 NVTNAIQGMFIVSLPFAVLHGGYWAIVAMVGIAHICCYTGKVLVQCLYEPDPATGQMVRVRDSYV 213
            ||.|:|.|:.::::||.....|    :.:..:..:.| :......|::....|:   :..|.:|.
Mouse    14 NVVNSIVGVSVLTMPFCFKQCG----IVLGALLLVFC-SWMTHQSCMFLVKSAS---LSKRRTYA 70

  Fly   214 AIAKVCFGPKLGARAVSIAQLIELLMTCILYVVVCGDLLAGTYP-----QGSFDSRSWMLF-VGI 272
            .:|...:| |.|...|..:.:..:|.:||.:.||.|||.:..:.     |.:...|.::|| |.:
Mouse    71 GLAFHAYG-KAGKMLVETSMIGLMLGSCITFYVVIGDLGSNFFAPLLGLQVTRTVRVFLLFAVSL 134

  Fly   273 FL-LP-------MGFLKSLKMVSTLSFWCTMSHIVINA----VILGYCLLQIGDWGWSKVRFSID 325
            |: ||       |..::|...::.|.:...|..||:::    :..|..|.|:....|..|...:.
Mouse   135 FIVLPLSLQRNMMASIQSFSAMALLFYTVFMFVIVLSSLKHGLFSGQWLRQVSYIRWEGVFRCVP 199

  Fly   326 MENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAAA------VFKAGFGYICFLT 384
            :  |.:|     |:..||: |||.:.  :|......|   |.|.|:      .|....|:..:::
Mouse   200 I--FGMS-----FACQSQV-LPTYDS--LDEPSVKTM---SSIFASSLNVVTAFYVMVGFFGYVS 251

  Fly   385 FQNDTQQVITNNLHSQGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKFPTIWNLD 449
            |.:.|...:..:..|.....|:....|:...:.:|:......:.|....|....|         |
Mouse   252 FTDATTGNVLIHFPSNPVTEMIRVGFVMSVAVGFPMMILPCRQALNTLLFEQQQK---------D 307

  Fly   450 GELKVWG----LGFRV---GVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIKIKGH 507
            |.....|    |.|:|   .|:..|::..:.||:...::||.|:..|:::.||.|..  |..|.|
Mouse   308 GTFAAGGYMPPLRFKVLTLSVVFGTMVGGVMIPNVETILGFTGATMGSLICFICPAL--IYKKAH 370

  Fly   508 LLDQKEIAKDYLIIGLGVL 526
              .....|:..|.:|||:|
Mouse   371 --KNAPSAQVVLWVGLGIL 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	95/409 (23%)
Slc38a10	XP_006534347.1	SLC5-6-like_sbd	6..381	CDD:382020	90/401 (22%)
		PTZ00121	<407..789	CDD:173412
		PTZ00449	<731..>991	CDD:185628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810