DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and slc36a1

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	XP_021336836.1	Gene:	slc36a1 / 559308	ZFINID:	ZDB-GENE-061117-1	Length:	468	Species:	Danio rerio

Alignment Length:	513	Identity:	117/513 - (22%)
Similarity:	193/513 - (37%)	Gaps:	110/513 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 DGGDTTEMSSNPFRNAGSWTNDGEGGGDGDGEYRNEYQSTSFNEYDGRYQQTDGFRQGSIASEGS 127
            ||.|.:....:|       |.|..  ....|..:.||:..             |.|.||...:..
Zfish     9 DGPDFSRRDESP-------TEDEP--IHSPGSRQTEYERI-------------GGRTGSSVLQTI 51

  Fly   128 SFVCEGEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAVLHGGYWA---IVAMVGIAHICCYTGK 189
            ..:.:|..|.|                    ::.||.||.:.|...   .:.::||..:.|.  .
Zfish    52 IHLLKGNIGTG--------------------LLGLPLAVRNAGLLVGPLSLLIMGIVAVHCM--N 94

  Fly   190 VLVQC-------LYEPDPATGQMVRV---RDSYVAIAKVCFGPKLGARAVSIAQLIELLMTCILY 244
            :||:|       |.:|..:.|..|..   ..|:::...:     .|...|::...|..|..|.:|
Zfish    95 LLVKCAHHLSAKLGKPFLSYGDAVEYGMENVSWLSRHSI-----WGRHVVNLFLNITQLGFCCVY 154

  Fly   245 VVVCGDLL--------AGT---------YPQGSFDSRSWMLFVGIFLLPMGFLKSLKMVSTLSFW 292
            .|...|.:        |.|         .|..|:|||.:|:|...|::.:.|:::||.::.|||.
Zfish   155 FVFLSDNVKQVVETANATTGNCHNNETAVPVPSYDSRLYMVFFLPFIILLVFIRNLKYLAPLSFA 219

  Fly   293 CTMSHIVINAVILGYCLLQIGDWGWSKVRFSIDM------ENFPISLGVIVFSYTS-QIFLPTLE 350
            ..:.......:|..|||..|.:        .|::      .::|:..|..:|::.. .:.|| ||
Zfish   220 ANICMCASLVLIYYYCLTNIPN--------PINLPLAGRGADYPLFFGTAIFAFEGIGVVLP-LE 275

  Fly   351 GNMIDRSKFNWMLDWSHIAAAVFKAGFGYICFLTFQNDTQQVITNNLHSQGFKGMVNFFLVIKAL 415
            ..|.:...|..:|..............|.|.::.|..:.:..||.||.......:|.........
Zfish   276 NKMQNPRNFTKVLYLGMGIVTFLYISLGTIGYIGFGEEIRGSITLNLPLCWLYQIVKLLYSFGIY 340

  Fly   416 LSYPLPYYAACELLERNFFRGPPK-TKFPTIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSI 479
            ::|.|.:|.:.|:|.      ||. .:....|.|..:|.:     ||.::..|..:||.||...:
Zfish   341 ITYALQFYVSAEILI------PPAVARCGPRWALMVDLSI-----RVALVGLTCALAILIPELDL 394

  Fly   480 LMGFIGSFTGTMLSFIWPCYFHIKIKGHLLDQKE--IAKDYLIIGLGVLFGVIGIYDS 535
            ::..:||.:.:.|:.|.|....| |..|..|.|.  .|||.||..||.:..:.|.|.|
Zfish   395 VISLVGSVSSSALALIIPPLLQI-ITFHNEDMKPWVFAKDILISVLGFVGFIAGTYTS 451

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	99/428 (23%)
slc36a1	XP_021336836.1	SLC5-6-like_sbd	44..453	CDD:320982	106/456 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594485
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840