Protein Alignment VGAT and SLC38A7

DIOPT Version :10

• Sequence 1: NP_610938.1
• Gene: VGAT / 36574
• FlyBaseID: FBgn0033911
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_060701.1
• Gene: SLC38A7 / 55238
• HGNCID: 25582
• Length: 462
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 108/499 - (21%)
• Similarity: 175/499 - (35%)
• Gaps: 150/499 - (30%)

  Fly   116 GFRQGSIASEGSSFVCEGEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAV-LHGGYWAIVAM-V 178
            |..:|:.::.|:.|:                   |.||..|..:::.|.|. ..||..|.:|: :
Human    45 GLDRGTTSTLGAIFI-------------------VVNACLGAGLLNFPAAFSTAGGVAAGIALQM 90

  Fly   179 GIAHICCYTGKVLVQCLYEPDPATGQMVRVRDSYVAIAKVCFGPKLGARAVSIAQLIELLMTCIL 243
            |:.........:|..|....:..|.|.|        :..||  .||......:|..:....|||.
Human    91 GMLVFIISGLVILAYCSQASNERTYQEV--------VWAVC--GKLTGVLCEVAIAVYTFGTCIA 145

  Fly   244 YVVVCGD------LLAGTYPQGSFDSRSW--------MLFVGIFLLPM------GFLKSLKMVST 288
            ::::.||      .:....|:|:  |..|        .|...:|:||:      ||.|....:|.
Human   146 FLIIIGDQQDKIIAVMAKEPEGA--SGPWYTDRKFTISLTAFLFILPLSIPREIGFQKYASFLSV 208

  Fly   289 LSFWCTMSHIVINAVILGYCLLQIGDWGWSKVRFSIDMENFPISLGVIVFSYTSQIFLPTLEGNM 353
            :..|...:.::|..:             |.      |.|..|                    ||:
Human   209 VGTWYVTAIVIIKYI-------------WP------DKEMTP--------------------GNI 234

  Fly   354 IDRSKFNWMLDWSHIAAAVFKA----GFGYICFLT---FQNDTQQ--------VITNNL------ 397
            :.|.. :||        |||.|    .||:.|.::   ..|..||        |:|..:
Human   235 LTRPA-SWM--------AVFNAMPTICFGFQCHVSSVPVFNSMQQPEVKTWGGVVTAAMVIALAV 290

  Fly   398 -HSQGFKGMVNFFLVI--KALLSYPLPYYAACELLERNFFRGPPKTKFPTIWNLDGELKVWGLGF 459
             ...|..|.:.|...:  ..|||||....|..  :.|.|......|.:| |.:..|...|.||..
Human   291 YMGTGICGFLTFGAAVDPDVLLSYPSEDMAVA--VARAFIILSVLTSYP-ILHFCGRAVVEGLWL 352

  Fly   460 RV-GVIVS--------------------TILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIK 503
            |. ||.|.                    |:|:|:|||....::..||......: |::|....|:
Human   353 RYQGVPVEEDVGRERRRRVLQTLVWFLLTLLLALFIPDIGKVISVIGGLAACFI-FVFPGLCLIQ 416

  Fly   504 IKGHLLDQKEIAKDYLIIGLGVLFGVIGIYDSGNALINAFEIGL 547
            .|...:::.:.|..::::..|||...:|.:..|....||..:.|
Human   417 AKLSEMEEVKPASWWVLVSYGVLLVTLGAFIFGQTTANAIFVDL 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:444915	100/455 (22%)
SLC38A7	NP_060701.1	SLC5-6-like_sbd	49..457	CDD:444915	106/490 (22%)